Brain 5-HT(2A) receptor occupancy of deramciclane in humans after a single oral administration - A positron emission tomography study

Psychopharmacology

Volumn 145, Issue 1, 1999, Pages 76-81

  Kanerva, Harri ^a   Kilkku, Olavi ^a   Vilkman, Harry ^b   Syvälahti, Erkka ^b   Någren, Kjell ^b   Kuoppamäki, Mikko ^c   Hietala, Jarmo ^c  

^a ORION CORPORATION   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

Author keywords

11C NMSP; Deramciclane fumarate; Positron emission tomography; Serotonin

Indexed keywords

3 METHYLSPIPERONE C 11; ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; BRAIN RECEPTOR; CLOZAPINE; DERAMCICLANE FUMARATE; RISPERIDONE; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; BORNANE DERIVATIVE; DERAMCICLANE; DOPAMINE RECEPTOR BLOCKING AGENT; SEROTONIN 1 RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ADULT; ARTICLE; CASE REPORT; CLINICAL TRIAL; CONCENTRATION RESPONSE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG RECEPTOR BINDING; DRUG TISSUE LEVEL; FEMALE; HUMAN; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; SCHIZOPHRENIA; VERTIGO; ANIMAL; BLOOD; BRAIN CORTEX; CHEMISTRY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; METABOLISM;

ADMINISTRATION, ORAL; ADULT; ANIMALS; BORNANES; CEREBRAL CORTEX; DOPAMINE ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RISPERIDONE; SEROTONIN ANTAGONISTS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0033158718     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130051034     Document Type: Article

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