Colon cancer: p53 expression and DNA ploidy. Their relation to proximal or distal tumor site

Revista Espanola de Enfermedades Digestivas

Volumn 91, Issue 7, 1999, Pages 485-488

  Garcia Hirschfeld Garcia, Juan María ^a,b   Blanes Berenguel, A ^a   Vicioso Recio, L ^a   Marquez Moreno A J ^a   Rubio Garrido, J ^a   Matilla Vicente, A ^a  

^a UNIVERSITY OF MÁLAGA   (Spain)

^b Facultad de Medicina   (Spain)

Author keywords

Colon cancer; DNA ploidy; p53 expression

Indexed keywords

DNA; PROTEIN P53;

AGED; ARTICLE; COLON TUMOR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; MIDDLE AGED; PATHOLOGY; PLOIDY; TUMOR SUPPRESSOR GENE;

AGED; COLONIC NEOPLASMS; DNA, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; MALE; MIDDLE AGED; PLOIDIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0033155779     PISSN: 11300108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Armitage NC, Ballantyne KC, Evans DF, et al. The influence of tumor DNA content of survival in colorectal cancer. Br J Cancer 1990;62:852-6.
2. Armitage NC, Ballantyne KC, Sheffield JP, et al. A prospective evaluation of the effect of tumor cell DNA content on recurrence in colorectal cancer. Cancer 1991;67:2599-604.
3. Jass JR, Mukawa K, Goh HS, et al. Clinical importance of DNA content in rectal cancer measured by flow cytometry. J Clin Pathol 1989;42:254-9.
4. Mazzei T, Tonelli F, Mini E, Mazzoni P, et al. Flow cytometric analysis of DNA ploidy and cell proliferative activity in colorectal cancer. Anticancer Res 1995;5:2247-53.
5. Albe X, Vassilakos P, Helfer-Guarnori K, et al. Independent prognostic value of ploidy in colorectal cancer. Cancer 1990;66:1168-75.
6. Levine AJ, Momand J, Finlay CA. The p53 tumor suppressor gene. Nature 1991;351:453-6.
7. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.
8. Iiyas M, Tomlinson I, Novelli MR, et al. Clinicopathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability. J Pathol 1996;179:370-5.
9. Lanza G, Maestri I, Drubini A, et al. p53 expression in colorectal cancer. Relation to tumor type, DNA ploidy pattern and short-term survival. Am Clin Pathol 1996;105: 604-12.
10. Bertorelle R, Esposito G, Del Mistro A, et al. Association of p53 gene and protein alterations with metastases in colorectal cancer. Am J Surg Pathol 1995;19:463-71.
11. Grewal H, Guillem JG, Klimstra DS, Cohen AM. p53 nuclear overexpression may not be an independent prognostic marker in early colorectal cancer. Dis Colon Rectum 1995;38(11):1176-81.
12. Chang F, Syrjänen S, Kurvinen K, Syrjänen K. The p53 tumor suppressor gene as a common cellular target in human carcinogenesis. Am J Gastroenterol 1993;88(2):174-86.
13. Baker SJ, Markowitz S, Fearon ER, et al. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 1990;249:912-5.
14. Hollstein M, Sidransky D, Vogelstein B, et al. p53 mutations in human cancers. Science 1991;253:49-53.
15. Umpleby HC, Ramson DL, Williamson HC. Peculiarities of mucinous colorectal cancer. Br J Surg 1985;72:715-8.
16. Minsky BD, Mies C, Rich TA. Colloid carcinoma of the colon and rectum. Cancer 1987;60:3103-12.
17. Sasaki O, Atkin WS, Jass JR. Mucinous carcinoma of the rectum. Histopathology 1987;11:259-72.
18. Kern SE, Fearon ER, Tersmette KWS, et al. Allelic loss in colorectal carcinoma. JAMA 1989;261:3099-103.
19. Laurent-Puig P, Olschwang S, Delattre O, et al. Association of ki-ras mutation with differentiation and tumor-formation pathways in colorectal carcinoma. Int J Cancer 1991;49:220-3.
20. Heerdt BG, Molinas S, Deitch D, Augenlicht LH. Agressive subtypes of human colorectal tumors frequently exhibit amplification of the c-myc gene. Oncogene 1991;6:125-9.
21. Heimann TM, Miller F, Martinelli, et al. Significance of DNA content abnormalities in small rectal cancer. Am J Surg 1989;159:525-8.
22. Kim YJ, et al. Ploidy in invasive colorectal cancer: implications form metastatic disease. Cancer 1991;68:638-41.
23. Cahill DP, Lengauer Ch, Yu J, et al. Mutations of mitotic checkpoint genes in human cancers. Nature 1998;392:300-3.
24. Lengauer Ch, Riggins GJ, Vogelstein B. Genetic inestability in colorectal cancers. Nature 1998;386:623-7.
25. Changchien CR, Wang JY, Tang R, Ho YS. Pathogenetics implications of DNA nondiploidy in colorectal cancers. Dis Colon Rectum 1997;40:1244-7.
26. Bufill JA. Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Int Med 1990;113:779-88.
27. Watatani M, Yoshida T, Kuroda K, et al. Allelic loss of chromosome 17p, mutation of the p53 gene, and microsatellite instability in right and left colorectal cancer. Cancer 1996;77(suppl): 1688-93.
28. Lleonart ME, García-Foncillas J, Sánchez-Prieto R, et al. Microsatellite instability and p53 mutations in sporadic right and left colon carcinoma. Different clinical and mollecular implications. Cancer 1998;83:889-95.
29. Jernvall P, Makinen M, Karttunen T, et al. Conserved region mutations of the p53 gene are concentrated in distal colorectal cancer. Int J Cancer 1997;74(1):97-101.
30. Dellatre O, Law D, Remvikos Y, et al. Multiple genetics alterations in distal and proximal colorectal cancer. Lancet 1989;2:353-6.