Generation of rhythmic patterns of activity by ventral interneurones in rat organotypic spinal slice culture

Journal of Physiology

Volumn 517, Issue 2, 1999, Pages 459-475

  Ballerini, L ^a   Galante, Micaela ^a   Grandolfo, Micaela ^a   Nistri, Andrea ^a  

^a SISSA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; BICUCULLINE; CALCIUM ION; MAGNESIUM ION; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POTASSIUM ION; STRYCHNINE; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; INTERNEURON; LOCOMOTION; NERVE CELL CULTURE; NERVE CELL MEMBRANE POTENTIAL; NERVE CONDUCTION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPINAL CORD VENTRAL HORN; ANIMAL CELL; DEPOLARIZATION; HYPERPOLARIZATION; INTRACELLULAR RECORDING; NEUROTRANSMISSION; PATCH CLAMP TECHNIQUE; PERIODICITY; SPINAL CORD SLICE; SPINAL GANGLION; SPINAL ORGANOTYPIC CULTURE; SYNAPTIC POTENTIAL; TISSUE CULTURE; VOLTAGE CLAMP TECHNIQUE; WHOLE CELL;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; BICUCULLINE; CALCIUM; ELECTROPHYSIOLOGY; EXCITATORY AMINO ACID ANTAGONISTS; EXTRACELLULAR SPACE; GABA ANTAGONISTS; GLYCINE AGENTS; INTERNEURONS; MAGNESIUM; PERIODICITY; POTASSIUM; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; STRYCHNINE; TETRODOTOXIN;

EID: 0033153231     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.0459t.x     Document Type: Article

References (43)

1. ARSHAVSKY, Y. I., DELIAGINA, T. G. & ORLOVSKY, G. N. (1997). Pattern generation. Current Opinion in Neurobiology 7, 781-789.
2. BALLERINI, L., BRACCI, E. & NISTRI, A. (1995). Desensitization of AMPA receptors limits the amplitude of EPSPs and the excitability of motoneurons of the rat isolated spinal cord. European Journal of Neuroscience 7, 1229-1234.
3. BALLERINI, L. & GALANTE, M. (1998). Network bursting by organotypic spinal slice cultures in the presence of bicuculline and/or strychnine is developmentally regulated. European Journal of Neuroscience 10, 2871-2879.
4. BEATO, M., BRACCI, E. & NISTRI, A. (1997). Contribution of NMDA and non-NMDA glutamate receptors to locomotor pattern generation in the neonatal rat spinal cord. Proceedings of the Royal Society B 264, 877-884.
5. BRACCI, E., BALLERINI, L. & NISTRI, A. (1996a). Spontaneous rhythmic bursts induced by pharmacological block of inhibition in lumbar motoneurons of the neonatal rat spinal cord. Journal of Neuropnysiology 75, 640-647.
6. BRACCI, E., BALLERINI, L. & NISTRI, A. (1996b). Localization of rhythmogenic networks responsible for spontaneous bursts induced by strychnine and bicuculline in the rat isolated spinal cord. Journal of Neuroscience 16, 7063-7076.
7. + induces locomotor-like patterns in the rat spinal cord in vitro: comparison with NMDA or 5HT induced activity. Journal of Neurophysiology 79, 2643-2652.
8. BRASCHLER, U. F., IANNONE , A., SPENGER, C., STREIT, J. & LÜSCHER, H. R. (1989). A modified roller tube technique for organotypic cocultures of embryonic rat spinal cord, sensory ganglia and skeletal muscle. Journal of Neuroscience Methods 29, 121-129.
9. CAZALETS, J. R, BORDE, M. & CLARAC, F. (1996). The synaptic drive from the spinal locomotor network to motoneurons in the newborn rat. Journal of Neuroscience 16, 298-306.
10. CAZALETS, J. R., SQALLI-HOUSSAINI, Y. & CLARAC, F. (1992). Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. Journal of Physiology 455, 187-204.
11. CHAMBERLIN, N. L., TRAUB, R. D. & DINGLEDINE, R. (1990). Role of EPSPs in initiation of spontaneous synchronized burst firing in rat hippocampal neurons bathed in high potassium. Journal of Neurophysiology 64, 1000-1008.
12. CHENG, J., STEIN, R. B., JOVANOVIC, K., YOSHIDA, K., BENNETT, D. J. & HUN, Y. (1998). Identification, localization and modulation of neural networks for walking in the mudpuppy (Necturus maculatus) spinal cord. Journal of Neuroscience 18, 4295-4304.
13. CHUB, N. & O'DONOVAN, M. J. (1998). Blockade and recovery of spontaneous rhythmic activity after application of neurotransmitter antagonists to spinal networks of the chick embryo. Journal of Neuroscience 18, 294-306.
14. DALE, N. & KUENZI, F. M. (1997a). Ion channels and the control of swimming in the Xenopus embryo. Progress in Neurobiology 53, 729-756.
15. DALE, N. & KUENZI, F. M. (1997b). Ionic currents, transmitters and models of motor pattern generators. Current Opinion in Neurobiology 7, 790-796.
16. FULTON, B. P. & WALTON, K. (1986). Electrophysiological properties of neonatal rat motoneurons studied in vitro. Journal of Physiology 370, 651-678.
17. GRILLNER, S., WALLEN, P. & BRODIN, L. (1991). Neuronal network generating locomotor behaviour in lamprey. Annual Review of Neuroscience 14, 169-199.
18. Ho, S. & O'DONOVAN, M. J. (1993). Regionalization and intersegmental coordination of rhythm-generating networks in the spinal cord of the chick embryo. Journal of Neuroscience 13, 1354-1371.
19. HOCHMAN, S., JORDAN, L. M. & MACDONALD, J. F. (1994). N-Methyl-D-aspartate receptor-mediated voltage oscillations in neurons surrounding the central canal in slices of rat spinal cord. Journal of Neurophysiology 72, 565-577.
20. HOCHMAN, S. & SCHMIDT, B. J. (1998). Whole cell recordings of lumbar motoneurones during locomotor-like activity in the in vitro neonatal rat spinal cord. Journal of Neurophysiology 79, 743-752.
21. JEFFERYS, J. G. R., TRAUB, R. D. & WHITTINGTON, M. A. (1996). Neuronal networks for induced '40 Hz' rhythms. Trends in Neurosciences 19, 202-208.
22. JOURDAIN, P., ISRAEL, J. M., DUPOUY, B., OLIET, H. R., ALLARD, M., VITIELLO, S., THEODOSIS, D. T. & POULAIN, D. A. (1998). Evidence for a hypothalamic oxytocin-sensitive pattern-generating network governing oxytocin neurons in vitro. Journal of Neuroscience 18, 6641-6649.
23. KIEHN, O., JOHNSON, B. R. & RAASTAD, M. (1996). Plateau properties in mammalian spinal interneurons during transmitter-induced locomotor activity. Neuroscience 75, 263-273.
24. KJAERULFF, O. & KIEHN, O. (1996). Distribution of networks generating and coordinating locomotor activity in the neonatal rat spinal cord in vitro: a lesion study. Journal of Neuroscience 16, 5777-5794.
25. KUDO, N., OZAKI, S. & YAMADA, T. (1991). Ontogeny of rhythmic activity in the spinal cord of the rat. In Neurobiological Basis of Human Locomotion, ed. SHIMAMURA, M., GRILLNER, S. & EDGERTON, V. R., pp. 127-136. Japan Scientific Societies Press, Tokyo.
26. KUDO, N. & YAMADA, T. (1987). N-Methyl-D,L-aspartate-induced locomotor activity in a spinal cord-hindlimb muscles preparation of the newborn rat studied in vitro. Neuroscience Letters 75, 43-48.
27. MARTY, A. & NEHER, E. (1983). Tight-seal whole-cell recording. In Single-Channel Recording, ed. SAKMANN, B. & NEHER, E., pp. 107-122. Plenum Press, New York and London.
28. MAYER, M. L. & WESTBROOK, G. L. (1987). The physiology of excitatory amino acids in vertebrate central nervous system. Progress in Neurobiology 28, 197-276.
29. MÜLLER, W. & SWANDULLA, D. (1995). Synaptic feedback excitation has hypothalamic neural networks generate quasirhythmic burst activity. Journal of Neurophysiology 73, 855-861.
30. NISHIMARU, H., IIZUKA, M., OZAKI, S. & KUDO, N. (1996). Spontaneous motoneuronal activity mediated by glycine and GABA in the spinal cord of rat fetuses in vitro. Journal of Physiology 497, 131-143.
31. PATON, J. F. R. (1997). Rhythmic bursting of pre-and post-inspiratory neurones during central apnoea in mature mice. Journal of Physiology 502, 623-639.
32. PATON, J. F. R. & RICHTER, D. W. (1995). Role of fast inhibitory synaptic mechanisms in respiratory rhythm generation in the maturing mouse. Journal of Physiology 484, 505-521.
33. PHELPS, P. E, BARBER, K. P. & VAUGHN, J. E. (1991). Embryonic development of choline acetyltrasnferase in thoracic spinal motor neurons: somatic and autonomie neurons may be derived from a common cellular group. Journal of Comparative Neurology 307, 77-86.
34. RAASTAD, M., JOHNSON, B. R. & KIEHN, O. (1990). The number of postsynaptic currents necessary to produce locomotor-related cyclic information in neurons in the neonatal rat spinal cord. Neuron 17, 729-738.
35. RAASTAD, M., JOHNSON, B. R. & KIEHN, O. (1997). Analysis of EPSCs and IPSCs carrying rhythmic, locomotor-related information in the isolated spinal cord of the neonatal rat. Journal of Neurophysiology 78, 1851-1859.
36. ROSSIGNOL, S. & DUBUC, R. (1994). Spinal pattern generation. Current Opinion in Neurobiology 4, 894-902.
37. B receptors in the generation of epileptiform activity in disinhibited hippocampal slice cultures. Neuroscience 61, 823-832.
38. SPENGER, C., BRASCHLER, U. F., STREIT, J. & LÜSCHER, H. R. (1991). An organotypic spinal cord-dorsal root-ganglion skeletal muscle coculture of embryonic rat. I. The morphological correlates of the spinal reflex arc. European Journal of Neuroscience 3, 1037-1053.
39. STREIT, J. (1996). Mechanisms of pattern generation in co-cultures of embryonic spinal cord and skeletal muscle. International Journal of Developmental Neuroscience 14, 137-148.
40. STREIT, J., SPENGER, C. & LÜSCHER, H. R. (1991). An organotypic spinal cord-dorsal root-ganglion skeletal muscle coculture of embryonic rat. II. Functional evidence for the formation of spinal reflex arcs in vitro. European Journal of Neuroscience 3, 1054-1068.
41. TRAUB, R. D. & DINGLEDINE, R. (1990). Model of synchronized epileptiform bursts induced by high potassium in CA3 region of rat hippocampal slice. Role of spontaneous EPSPs in initiation. Journal of Neurophysiology 64, 1009-1018.
42. WHEATLEY, M., JOVANOVIC, K., STEIN, R. B. & LAWSON, V. (1994). The activity of interneurons during locomotion in the in vitro Necturus spinal cord. Journal of Neurophysiology 71, 2025-2032.
43. ZISKIND-CONHAIM, L. (1988). Electrical properties of motoneurons in the spinal cord of rat embryos. Developmental Biology 128, 21-29.