Increased level of exon 12 alternatively spiced BRCA2 transcripts in tumor breast tissue compared with normal tissue

Cancer Research

Volumn 59, Issue 11, 1999, Pages 2546-2550

  Bièche, Ivan ^a,b   Lidereau, Rosette ^a  

^a CENTRE RENÉ HUGUENIN   (France)

^b FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ALTERNATIVE RNA SPLICING; ARTICLE; BREAST TUMOR; CODON; DNA DAMAGE; DNA STRAND BREAKAGE; EXON; HUMAN; HUMAN TISSUE; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ALTERNATIVE SPLICING; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST; BREAST NEOPLASMS; EXONS; FEMALE; HUMANS; NEOPLASM PROTEINS; POLYMERASE CHAIN REACTION; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0033152121     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Miki, Y., Swensen, J., Shattuck-Eidens, D., Futreal, P. A., Harshman, K., Tavtigian, S., Liu, Q., Cochran, C., Bennett, L., M., Ding, W., Bell, R., Rosenthal, J., Hussey, C., Tran, T., McClure, M., Frye, C., Hattier, T., Phelps, R., Haugen-Stano, A., Katcher, H., Yakumo, K., Gholami, Z., Shaffer, D., Stone, S., Bayer, S., Wray, C., Bogden, R., Dayananth, P., Ward, J., Tonin, P., Narod, S., Briston, P. K., Norris, F. H., Helvering, L., Morrison, P., Rosteck, P., Lai, M., Barrett, J. C., Lewis, C., Neuhausen, S., Cannon-Albright, L., Goldgar, D., Wiseman, R., Kamb, A., and Skolnick, M. H. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science (Washington DC), 266: 66-71, 1994.
2. Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S., Gumbs, C., Micklem, G., Barfoot, R., Hamoudi, R., Patel, S., Rice, C., Biggs, P., Hashim, Y., Smith, A., Connor, F., Arason, A., Gudmundsson, J., Ficenec, D., Kelsell, D., Ford, D., Tonin, P., Bishop, D. T., Spurr, N. K., Ponder, B. A. J., Eeles, R., J., Peto, P., Devilee, C., Comelisse, C., Lyunch, H., Narod, S., Lenoir, G., Egilsson, V., Barkadottir, R. B., Easton, D. F., Bentley, D. R., Futreal, P. A., Ashworth, A., and Stratton, M. R. Identification of the breast cancer susceptibility gene BrCA2. Nature (Lond.), 378: 789-792, 1995.
3. Zhang, H., Tombline, G., and Weber, B. L. BRCA1, BRCA2, and DNA damage response: collision or collusion? Cell, 92; 433-436, 1998.
4. Shattuck-Eidens, D., McClure, M., Simard, J., Labrie, F., Narod, S., Couch, F., Hoskins, K., Weber, B., Castilla, L., Erdos, M., Brody, L., Friedman, L., Ostermeyer, E., Szabo, C., King, M. C., Jhanwar, S., Offit, K., Norton, L., Gilewski, T., Lubin, M., Osborne, M., Black, D., Boyd, M., Steel, M., Ingles, S., Haile, R., Lindblom, A., Olsson, H., Borg, A., Bishop, D. T., Solomon, E., Radice, P., Spatti, G., Gayther, S., Ponder, B., Warren, W., Stratton, M., Liu, Q., Fujimura, F., Lewis, C., Skolnick, M. H., and Goldgar, D. E. A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. J. Am. Med. Assoc., 273: 535-541, 1995.
5. Couch, F. J., Farid, L. M., DeShano, M. L., Tavtigian, S. V., Calzone, K., Campeau, L., Peng, Y., Bogden, B., Chen, Q., Neuhausen, S., Shattuck-Eidens, D., Godwin, A. K., Daly, M., D. M., Radford, S., Sedlacek, J., Rommens Simard, J., Garber, J., Merajver, S., and Weber, B. L. BRCA2 germline mutations in male breast cancer cases and breast cancer families. Nat. Genet., 13: 123-125, 1996.
6. Phelan, C. M., Lancaster, J. M., Tonin, P., Gumbs, C., Cochran, C., Carter, R., Ghadirian, P., Perret, C., Moslehi, R., Dion, F., Faucher, M. C., Dole, K., Karimi, S., Foulkes, W., Lounis, H., Warner, E., Goss, P., Anderson, D., Larsson, C., Narod, S. A., and Futreal, A. P. Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families. Nat. Genet., 13: 120-122, 1996.
7. Lancaster, J. M., Wooster, R., Mangion, J., Phelan, C. M., Cochran, C., Gumbs, C., Seal, S., Barfoot, R., Collins, N., Bignell, G., Patel, S., Hamoudi, R., Larsson, C., Wiseman, R. W., Berchuck, A., Dirk Iglehart, J., Stratton, M. R., and Futreal, P. A. BRCA2 mutations in primary breast and ovarian cancers. Nat. Genet., 13: 238-244, 1996.
8. Miki, Y., Katagiri, T., Kasumi, F., Yoshimoto, T., and Nakamura, Y. Mutation analysis in the BRCA2 gene in primary breast cancers. Nat. Genet., 13: 245-247, 1996.
9. Teng, D. H. F., Bogden, R., Mitchell, J., Baumgard, M., Bell, R., Berry S., Davis, T., Ha, P. C., Kehrer, R., Jammulapati, S., Chen, Q., Offit, K., Skolnick, M. H., Tavtigian, S. V., Jhanwar, S., Swedlund, B., Wong, A. K. C., and Kamb, A. Low incidence of BRCA2 mutations in breast carcinoma and other cancers. Nat. Genet., 13: 241-244, 1996.
10. Lu, M., Conzen, S. D., Cole, C. N., and Arrick, B. A. Characterization of functional messenger RNA splice variants of BRCA1 expression in nonmalignant and tumor-derived breast cells. Cancer Res., 56: 4578-4581, 1996.
11. Wilson, C. A., Payton, M. N., Elliot, G. S., Buaas, F. W., Cajulis, E. E., Grosshans, D., Ramos, L., Reese, D., Slamon, D. J., and Calzone, F. J. Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-△11b. Oncogene, 14: 1-16, 1997.
12. Xu, C. F., Chambers, J. A., Nicolai, H., Brown, M. A., Hujeirat, Y., Mohammed, S., Hodgson, S., Kelsell, D. P., Spurr, N. K., Bishop, D. T., and Solomon. E. Mutations and alternative splicing of the BRCA1 gene in UK breast/ovarian cancer families. Genes Chromosomes Cancer, 18: 102-110, 1997.
13. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
14. Pannetier, C., Delassus, S., Darche, S., Saucier, C., and Kourilsky, P. Quantitative titration of nucleic acids by enzymatic amplification reactions run to saturation. Nucleic Acids Res., 21: 577-583, 1993.
15. Tavtigian, S. V., Simard, J., Rommens, J., Couch, F., Shattuck-Eidens, D., Neuhausen, S., Merajver, S., Thorlacius, S., Offit, K., Stoppa-Lyonnet, D., Belanger, C., Bell, R., Berry, S., Bogden, R., Chen, Q., Davis, T., Dumont, M., Frye, C., Hattier, T., Jammulapati, S., Janecki, T., Jiang, P., Kehrer, R., Leblanc, J. F., Mitchell, J. T., McArthur-Morrison, J., Nguyen, K., Peng, Y., Samson, C., Schroeder, M., Snyder, S. C., Steele, L., Stringfellow, M., Stroup, C., Swedlund, B., Swensen, J., Teng, D., Thomas, A., Tran, T., Tranchant, M., Weaver-Feldhaus, J., Wong, A. K. C., Shizuya, H., Eyfjord, J. E., Cannon-Albright, L., F. Labrie, F., Skolnick, M. H., Weber, B., Kamb, A., and Goldgar, D. E. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nat. Genet., 12: 333-337, 1996.
16. Spillman, M. A., and Bowcock, A. M. BRCA1 and BRCA2 mRNA levels are coordinately elevated in human breast cancer cells in response to estrogen. Oncogene, 13: 1639-1645, 1996.
17. Siddique, H., Zou, J-P. Rao, V. N., and Reddy, E. S. P. The BRCA2 is a histone acetyltransferase. Oncogene, 16: 2283-2285, 1998.
18. Milner, J., Ponder, B., Hughes-Davies, L., Seltmann, M., and Kouzarides, T. Transcriptional activation functions in BRCA2. Nature (Lond.), 386: 772-773, 1997.
19. Chen, P. L., Chen, C. F., Chen, Y., Xia, J., Sharp, D., and Lee, W. H. The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc. Natl. Acad. Sci. USA, 95: 5287-5292, 1998.