Magnesium therapy in type 1 diabetes. A double blind study concerning the effects on kidney function and serum lipid levels

Magnesium Research

Volumn 12, Issue 2, 1999, Pages 123-130

  Hägg, Erik ^a   Carlberg, Bo C ^a   Hillörn, Valter S ^a   Villumsen, Jørgen ^a  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Kidney function; Magnesium treatment; Type 1 (insulin dependent) diabetes mellitus

Indexed keywords

CREATINE; FIBRINOGEN; HEMOGLOBIN; LIPID; MAGNESIUM; TRIACYLGLYCEROL;

ADULT; ALBUMINURIA; ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY; MALE; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; URINE;

ADULT; ALBUMINURIA; CREATINE; DIABETES MELLITUS, TYPE 1; DOUBLE-BLIND METHOD; FEMALE; FIBRINOGEN; HEMOGLOBINS; HUMANS; KIDNEY; LIPIDS; MAGNESIUM; MALE; MIDDLE AGED; TRIGLYCERIDES;

EID: 0033147108     PISSN: 09531424     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Grafton, G. & Baxter, M.A. (1992): The role of magnesium in diabetes mellitus. A possible mechanism for the development of diabetic complications. J.Diab. Comp. 6, 143-149.
2. Resnick, L.M. (1993): Ionic basis of hypertension, insulin resistance, vascular disease, and related disorders. The mechanism of 'Syndrome X'. Am. J. Hypertension 6, 123S-134S.
3. Ma, J., Folsom, A.R., Melnick, S.L., Eckfeldt, J.H., Sharrett, A.R., Nabulsi, A.A., Hutchinson, R.G. & Metcalf, P.A. (1995): Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. J. Clin. Epidemiol. 48, 927-940.
4. Garland, H.O. (1992): New experimental data on the relationship between diabetes mellitus and magnesium. Magnes. Res . 5, 193-202.
5. Sjögren, A., Florén, C.-H. & Nilsson, Å. (1988): Magnesium, potassium and zinc deficiency in subjects with type II diabetes mellitus. Acta Med. Scand. 224, 461-465.
6. Ceriello, A., Giugliano, D., Dello Russo, P. & Passariello, N. (1982): Hypomagnesemia in rela- tion to diabetic retinopathy. Diabetes Care 5, 558-559.
7. McNair, P., Christiansen, C., Madsbad, S., Lauritzen, E., Faber, O., Binder, C. & Transböl. I. (1978): Hypomagnesemia, a risk factor in diabetic retinopathy. Diabetes 27, 1075-1077.
8. Wada, M., Fujii, S., Takemura, T., Seki, J. & Akai, T. (1983): Magnesium levels and diabetic retinopathy. Magnes. Bull. 1, 12-14.
9. Dyckner, T., Hägg, E., Lithner, F., Nyhlin, H., & Wester, P.O. (1988): Muscle magnesium and capillary basement membrane thickness in diabetes mellitus. Diabete Metab. 14, 619-622.
10. Raccah, D., Gallice, P., Pouget, J. & Vague, P. (1992): Hypothesis: low Na/K-ATPase activity in the red cell membrane, a potential marker of the predisposition to diabetic neuropathy. Diabete Metab. 8, 236-241.
11. +)ATPase activity in Type 1 (insulin-dependent) diabetic subjects and its activation by homologous plasma. Diabetologia 29, 623-628.
12. Rahmani-Jourdheuil, D., Mourayre, Y., Vague, Ph., Boyer, J. & Juhan-Vague, I. (1987): In vivo insulin effect on ATPase activities in erythrocyte membrane from insulin-dependent diabetics. Diabetes 36, 991-995.
13. Mimura, M., Makino, H., Kanatsuka, A., Asai, T. & Yoshida, S. (1994): Reduction of erythrocyte (NaK)ATPase activity in type 2 (non-insulin-dependent) diabetic patients with microalbuminuria. Horm. Metab. Res. 26, 33-38.
14. Testa, I., Rabini, R. A., Fumelli, P., Bertoli, E. & Mazzanti, L. (1988): Abnormal membrane fluidity and acetylcholinesterase activity in erythrocytes from insulin-dependent diabetic patients. J. Clin. Endocr. Metab. 67, 1129-1133.
15. Skou, J.Ch. (1957): The influence of some cations on an adenosine triphosphatase from peripheral nerves. Biochim. Biophys. Acta 23, 394-401.
16. Grafton, G., Bunce, C.M., Sheppard, M.C., Brown, G. & Baxter, M.A. (1992): Effect of Mg on Na-dependent inositol transport. Role for Mg in etiology of diabetic complications. Diabetes 41, 35-39.
17. Mathiesen, E.R., Hommel, E., Giese, J. & Parving H.-H. (1991): Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria. Br. Med. J. 303, 81-87.
18. Lewis, E.J., Hunsicker, L.G., Bain, R.P. & Rohde, R.D.(1993): The effect of angiotensin-converting- enzyme inhibition on diabetic nephropathy. N.Engl. J. Med. 329, 1456-62.
19. Björck, S., Mulec, H., Johnsen, S.A., Nordén, G. & Aurell, M. (1992): Renal protective effect of enalapril in diabetic nephropathy. Br. Med. J. 304, 339-343.
20. Stevenson, R.N., Keywood, Ch., Amadi, A.A., Davies, R. & Patterson, D.L.H. (1991): Angiotensin converting enzyme inhibitors and magnesium conservation in patients with congestive cardiac failure. Br Heart J. 66, 19-21.
21. Sjögren, A., Florén, C.-H., Nilsson, Å. (1988): Oral administration of magnesium hydroxide to subjects with insulin-dependent diabetes mellitus: effects on magnesium and potassium levels and on insulin requirements. Magnesium 7, 117-122.
22. Råstam, L. & Sjönell, G. (1991): A new device for measuring blood pressure in adults. Lancet 337, 249-250.
23. Brøchner-Mortensen, J. (1972): A simple method for the determination of glomerular filtration rate. Scand. J. Clin. Lab. Invest. 30, 271-274.
24. Borssén. B., Bergenheim, T. & Lithner, F. (1990): The epidemiology of fool lesions in diabetic patients aged 15-50 years. Diabet. Med. 7, 438-444.
25. Jeppsson, J.-O., Jerntorp, P. Sundkvist, G., Englund, H. & Nylund, V. (1986): Measurement of hemoglobin A1C by a new liquid-chromatographic assay: methodology, clinical utility, and relation to glucose tolerance evaluated. Clin. Chem. 32, 1867-1872.
26. Betteridge, D.J. (1989): Lipids, diabetes, and vascular disease: The time to act. Diabet. Med. 6, 195-218.
27. Kapelrud, H., Bangstad, H.-J., Dahl-Jörgensen, K., Berg, K. & Hansen, K.F. (1991): Serum Lp(a) lipoprotein concentrations in insulin dependent diabetic patients with microalbuminuria. Lancet 303, 675-678.
28. Maser, R.E., Usher, D., Becker, D.J., Drash, A.L., Kuller, L.H. & Orchard T.J. (1993): Lipoprotein(a) concentration shows little relationship to IDDM complications in the Pittsburgh Epidemiology of Diabetes Complications Study Cohort. Diabetes Care 16, 755-758..
29. Ganda, O.P. & Arkin, C.F. (1992): Hyperfibrinogenemia. An important risk factor for vascular complications in diabetes. Diabetes Care 15, 1245-1250.