Enhancement of 5-fluorouracil cytotoxicity on human colon cancer cells by retrovirus-mediated Interferon-α gene transfer

International Journal of Oncology

Volumn 14, Issue 6, 1999, Pages 1143-1151

  Sabaawy, Hatem M E ^a   Ikehara, Susumu ^a,c   Adachi, Yasushi ^a,c   Quan, Shou ^a   Feldman, Eric ^a   Kancherla, Ram ^a   Abraham, Nader G ^a,b   Ahmed, Tauseef ^a  

^a WESTCHESTER MEDICAL CENTER   (United States)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

5 fluorouracil; Colon cancer; Gene transfer; Interferon

Indexed keywords

ALPHA INTERFERON; ANTINEOPLASTIC ANTIMETABOLITE; FLUOROURACIL; MESSENGER RNA;

ADENOCARCINOMA; ANIMAL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CELL STRAIN 3T3; CELL SURVIVAL; COLON TUMOR; DRUG EFFECT; GENE TRANSFER; GENETIC TRANSDUCTION; GENETICS; HUMAN; METABOLISM; MOUSE; MULTIMODALITY CANCER THERAPY; NORTHERN BLOTTING; PATHOLOGY; PHYSIOLOGY; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIROLOGY;

3T3 CELLS; ADENOCARCINOMA; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, NORTHERN; CELL DIVISION; CELL SURVIVAL; COLONIC NEOPLASMS; COMBINED MODALITY THERAPY; FLUOROURACIL; GENE TRANSFER TECHNIQUES; HUMANS; INTERFERON-ALPHA; MICE; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSDUCTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0033146438     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Tournagid C, Louvet C, Gramont A, Lucchi E, Seitz JF, Mal F, Raymond E, Cady J, Carola E and Krulick M: Bimonthly high dose leucovorin and 5-fluorouracil 48-h infusion with interferon-alpha-2a in patients with advanced colorectal carcinoma. Cancer 79: 1094-1099, 1997.
2. Chertkov JL, Jiang S, Lutton JD, Harrison J, Levere RD, Tiefenthaler M and Abraham NG: The hematopoietic stromal microenvironment promotes retrovirus-mediated gene transfer into hematopoietic stem cells. Stem Cells 11: 218-227, 1993.
3. Abraham NG, Da Silva J-L, Lavrovsky Y, Stoltz RA, Kappas A, Dunn MW and Schwartzman ML: Adenovirus mediated heme oxygenase-1 gene transfer into rabbit ocular tissue. Invest Ophthalmol Vis Sci 36: 2202-2208, 1995.
4. +) of normal and chronic myelogenous leukemia. In: Acute Leukemias VII. Experimental Approaches and Novel Therapies. Hiddemann W, Buchner T, Wormann B, Ritter J, Creutzig U, Keating M and Plunkett W (eds). Springer-Verlag, Berlin, pp405-412, 1998.
5. Ahmed T, Lutton JD, Feldman E, Tani K, Asano S and Abraham NG: Gene transfer of alpha interferon into hematopoietic stem cells. Leuk Res 22: 119-124, 1998.
6. Cohen AM, Minsky BD and Schiisky RL: Colon cancer. In: Cancer: Principles and Practices of Oncology. 4th edition. De Vita VT, Hellman S and Rosenberg SA (eds). J.B. Lippincott, Philadelphia, pp929-977, 1993.
7. Koshiji M, Adachi Y, Taketani S, Takeuchi K, Hioki K and Ikehara S: Mechanisms underlying apoptosis induced by combination of 5-fluorouracil and interferon-γ. Biochem Biophys Res Commun 240: 376-381, 1997.
8. Sotos GA, Grogan L and Allegra CJ: Preclinical and clinical aspects in biomodulation of 5-fluorouracil. Cancer Treat Rev 20: 11-49, 1994.
9. Makino M, Shirai H, Sugamura K, Kimura O, Maeta M, Itoh H and Kaibara N: Increased apoptosis in human colorectal cancer after preoperative treatment with 5-fluorouracil. Oncol Rep 3: 281-285, 1996.
10. Walder S: Antineoplastic activity of the combination of 5-fluorouracil and interferon: preclinical and clinical results. Semin Oncol 19 (Suppl 4): 338-340, 1992.
11. Grem JL, McAtee N, Murphy RF, Balis FM, Steinberg SM, Hamilton JM, et al: A pilot study of interferon alfa-2a in combination of 5-fluorouracil plus high dose leucovorin in metastatic gastrointestinal carcinoma. J Clin Oncol 9: 1811-1820, 1991.
12. Ogura H, Tani K, Keiya Ozawa K, Nagata S, Asano S and Takaku F: Implantation of genetically manipulated fibroblasts into mice as antitumor α-interferon therapy. Cancer Res 50: 5102-5106, 1990.
13. Markowitz D, Goff S and Bank A: A safe packaging line for gene transfer separating viral genes into two different plasmids. J Virol 62: 1120-1124, 1988.
14. Chomczyski R and Sacchi N: Single-step method of RNA isolation by acid guanidium isothiocyanate-m phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
15. Goodman AI, Choudhury M, Da Silva J-L, et al: Quantitative measurement of heme oxygenase-1 in the human adenocarcinoma. J Cell Biochem 63: 342-348, 1996.
16. Miller AD, Trauber DR and Buttimore C: Factors involved in the production of helper virus-free retrovirus vectors. Somatic Cell Mol Genet 12: 175-183, 1986.
17. Palmer TD, Hock RA, Osborne WRA and Miller AD: Efficient retrovirus-mediated transfer and expression of a human adenosine deaminase gene in diploid skin fibroblasts from an adenosine dcaminase-deficient human. Proc Natl Acad Sci USA 84: 1055-1059, 1987.
18. Kozak M: The scanning model for translation: an update. J Cell Biol 108: 229-241, 1989.
19. Markowitz D, Goff S and Bank A: Construction and use of a safe and efficient amphotropic packaging cell line. Virology 167: 400-406, 1989.
20. Miller AD and Buttimore C: Redesign of retrovirus packaging cell line avoids recombination leading to helper virus production. Mol Cell Biol 6: 2895-2902, 1989.
21. Pitha PM: Interferon: a new class of tumor suppressor genes? Cancer Cells 2: 215-216, 1990.
22. Gutterman JU and Hersh EM: Immunotherapy. In: Cancer Medicine. Holland JF and Frei E (eds). Lea and Febiger, Philadelphia, PA, pp1100-1132, 1982.
23. Elias L and Crissman HA: Interferon effects upon the adenocarcinoma 38 and HL-60 cell lines: antiproliferative responses and synergetic interactions with halogenated pyrimidine antimetabolites. Cancer Res 48: 4868-4873, 1988.
24. Gewert DR, Mooer G and Clemens MJ: Inhibition of cell division by interferons. The relationship between changes in the utilization of thymidine for DNA synthesis and control of proliferation in Daudi cells. Biochem J 214: 983-990, 1983.
25. Lee M, Price D, Specht S, Stemmler N and Katoh A: Interferon modulation of 5-fluorouracil: use in neoadjuvant therapy inhibits liver metastasis in nude mice. Anticancer Drugs 3: 413-418, 1992.
26. Pazdur R, Ajani JA, Patt YZ, Winn R, Jackson D, Shepard B, DuBrow L, Campos L, Quaraishi M, Faintuch J, Abbruzzese JL, Gutterman J and Levin B: Phase II study of fluorouracil and recombinant interferon alfa-2-α in previously untreated advanced colorectal carcinoma. J Clin Oncol 8: 2027-2031, 1990.
27. Schwartz EL, Hoffman M, O'Connor CJ and Walder S: Stimulation of 5-fluorouracil metabolic activation by interferon-α in human colon carcinoma cells. Biochem Biophys Res Commun 182: 1232-1239, 1992.
28. Shchepotin IB, Soldatenkov V, Buras RR, Nauta RJ, Shanahang M and Evans SR: Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil and hyperthermia. Anticancer Res 14: 1027-1032, 1994.
29. Wader S: Antineoplastic activity of the combination of 5-fluorouracil and interferon: preclinical and clinical studies. Semin Oncol 19: 38-40, 1992.