The accentuating effect of low magnesium concentration on cholestane-3ß, 5α, 6β-triol-induced decrease of LDL uptake by cultured endothelial cells

Magnesium Research

Volumn 12, Issue 2, 1999, Pages 89-98

  Zhou, Qi ^a   Hulea, Stefan ^b   Kummerow, Fred A ^a,b  

^a Harlan E Moore Heart Research Foundation   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

5 ; 6 triol; Atherosclerosis; Cholestane 3 ; Cultured endothelial cells; Ldl receptor; Low magnesium

Indexed keywords

ANTILIPEMIC AGENT; CHOLESTANE 3,5,6 TRIOL; CHOLESTANE-3,5,6-TRIOL; CHOLESTANOL; LOW DENSITY LIPOPROTEIN; MAGNESIUM; RADIOACTIVE IODINE;

ARTICLE; CELL CULTURE; CELL MEMBRANE; DOSE RESPONSE; DRUG EFFECT; HUMAN; METABOLISM; VASCULAR ENDOTHELIUM;

ANTILIPEMIC AGENTS; CELL MEMBRANE; CELLS, CULTURED; CHOLESTANOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; IODINE RADIOISOTOPES; LIPOPROTEINS, LDL; MAGNESIUM;

EID: 0033142533     PISSN: 09531424     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Yeagle, P.L. (1988): Cholesterol and the cell membrane. In: Biology of cholesterol, ed. P.L. Yeagle, pp. 121-145. Boca Raton: CRC Press.
2. Smith, L.L. & Johnson, B.H. (1989): Biological activities of oxysterols. Free Radic. Biol. Med. 7, 285-332.
3. Bradley, W.A. & Gianturco, S.H. (1988): Lipoprotein receptors in cholesterol metabolism. In: Biology of cholesterol, ed. P.L. Yeagle, pp. 95-120. Boca Raton: CRC Press.
4. Lorenzo, J.L., Allorio, M., Bernini, F., Corsini, A. & Fumagalli, R. (1987): Regulation of low density lipoprotein metabolism by 26-hydroxycholesterol in human fibroblasts. FEBS Lett. 218, 77-80.
5. Brown, M.S. & Goldstein, J.L. (1975): Regulation of the activity of the low density lipoprotein receptor in human fibroblasts. Cell 6, 307-316.
6. Mahfouz, M.M., Smith, T.L. & Kummerow, F.A. (1992): Decreased uptake of low density lipoprotein by LLC-PK cells cultured at low magnesium concentration. Magnes. Res. 5, 249-254.
7. Yokoyama, S., Nishida, H.I., Smith, T.L. & Kummerow, F.A. (1994): Combined effects of magnesium deficiency and an atherogenic level of low density lipoprotein on uptake and metabolism of low density lipoprotein by cultured human endothelial cells. I. Biochemical data. Magnes. Res. 7, 87-95.
8. Smith, L.L. (1992): The oxidation of cholesterol. In: Biological effect of cholesterol oxides, eds S-K. Peng & R.J. Morin, pp. 7-31. Boca Raton: CRC Press.
9. Esterman, A.L., Baum, H., Javitt, N.B. & Darlington, G. (1983): 26-Hydroxycholesterol: regulation of 3-hydroxy-3-methylglutaryl-CoA reductase activity in Chinese hamster ovary cell culture. J. Lipid Res. 24, 1304-1309.
10. Taylor, F.R. (1992): Correlation among oxysterol potencies in the regulation of the degradation of 3-hydroxy-3-methylglutaryl CoA reductase, the repression of 3-hydroxy-3-methylglutaryl CoA synthase and affinities for the oxysterol receptor. Biochem. Biophys. Res. Commun. 186, 182-189.
11. Peng, S.K., Morin, R.J., Tham, P. & Taylor, C.B. (1985): Effects of oxygenated derivatives of cholesterol on cholesterol uptake by cultured aortic smooth muscle cells. Artery 13, 144-164.
12. Kummerow, F.A. (1992): Hypothesis: Possible role of magnesium and calcium in the development of structure and function of the plasma membrane in mammalian cells and in human diseases. J. Am. Coll. Nutr. 11, 410-425.
13. Mahfouz. M.M., Zhou, Q. & Kummerow, F.A. (1994): Cholesterol oxides in plasma and lipoproteins of magnesium-deficient rabbits and effects of their lipoproteins on endothelial barrier function. Magnes. Res. 7, 207-222.
14. Zhou, Q., Mahfouz, M.M. & Kummerow, F.A. (1994): Effect of dietary magnesium deficiency with/without cholesterol supplementation on phospholipid content in liver, plasma and erythrocytes of rabbits. Magnes. Res. 7, 23-30.
15. Jaya, P. & Kurup, P.A. (1987): Magnesium deficiency and metabolism of lipids in rats fed cholesterolfree and cholesterol-containing diet. Indian J. Biochem. Biophys. 24, 92-95.
16. Gueux, E. & Rayssiguier, Y. (1981): The hypercholesterolaemic effect of magnesium deficiency following cholesterol feeding in the rat. Magnes. Bull. 2, 126-129.
17. Mahfouz, M.M., Smith, T.L. & Kummerow, F.A. (1989): Changes in phospholipid composition and calcium flux in LLC-PK cells cultured at low magnesium concentrations. Biochim. Biophys. Acta 1006, 75-83.
18. Zhou, Q. & Kummerow, F.A. (1995): The effects of magnesium deficiency on DNA and lipid synthesis in cultured human umbilical arterial endothelial cells. Magnes. Res. 8, 145-150.
19. Gunther, T., Vormann, J., Hollriegl, V., Disch, G. & Classen, H.G. (1992): Role of lipid peroxidation and vitamin E in magnesium deficiency. Magnes. Bull. 14, 57-66.
20. Srivastava, R.A., Ito, H., Hess, M., Srivastava, N. & Schonfeld, G. (1995): Regulation of low density lipoprotein receptor gene expression in HepG2 and Caco2 cells by palmitate. oleate, and 25-hydroxycholesterol. J. Lipid Res. 36, 1434-1446.
21. Morin, R.J. & Peng, S-K. (1992): Cholesterol oxides in plasma and tissues. In: Biological effect of cholesterol oxides, eds S-K. Peng & R.J. Morin, pp. 89-101. Boca Raton: CRC Press.
22. Zhou, Q., Wasowicz, E., Kummerow, F.A. (1995): Failure of vitamin E to protect cultured human arterial smooth muscle cells against oxysterol-induced cytotoxicity. J. Am. Coll. Nutr. 14, 169-175.
23. Burstein, M., Scholnick, H.R. & Morfin R. (1970): Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J. Lipid Res. 11, 583-595.
24. McFarlane, A.S. (1958): Use of labelled plasma proteins in study of nutritional problems. Nature 182, 53.
25. Folch, J., Lees, M. & Sloane, G.H. (1957): A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226, 497-509.
26. Goldstein J.L. & Brown, M.S. (1974): Binding and degradation of low density lipoproteins by cultured human fibroblasts: Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. J. Biol. Chem. 249, 5153-5162.
27. Bellosta, S., Corsini, A., Bernini, F., Granata, A., Didoni, G. & Mazzotti, M. (1993): 27-Hydroxycholesterol modulation of low density lipoprotein metabolism in cultured human hepatic and extrahepatic cells. FEBS Lett. 332, 115-118.
28. Field, F.J., Fujiwara, D., Born, E., Chappell, D.A. & Mathur, S.N. (1993): Regulation of LDL receptor expression by luminal sterol flux in CaCo2 cells. Arterioscler. Thrombo. 13, 729-737.
29. Dawson, P.A., Hofmann, S.L., van der Westhuyzen, D.R., Sudof, T.C., Brown, M.S. & Goldstein, J.L. (1988): Sterol-dependent repression of low density lipoprotein receptor mediated by 16-base pair sequence adjacent to binding site for transcription factor Spl. J. Biol. Chem. 263, 3372-2379.
30. Sudhof, T.C., van der Westhuyzen, D.R., Sudof, T.C., Brown, M.S. & Goldstein, J.L. (1987): Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene. J. Biol. Chem. 262, 10773-10779.
31. Sharkey, M.F., Miyanohara, A., Elam, R.L., Friedmann, T. & Witztum, J.L. (1990): Post-transcriptional regulation of retroviral vector-transduced low density lipoprotein receptor activity. J. Lipid Res. 31, 2167-2178.
32. Casciola, L.A., van der Westhuyzen D.R., Gevers, W. & Coetzee, G.A. (1988): Low density lipoprotein receptor degradation is influenced by a mediator protein(s) with a rapid turnover rate, but is unaffected by receptor up- or down-regulation. J. Lipid Res. 29, 1481-1489.
33. Kou, I-L., Pikul, J. & Kummerow, F.A. (1991): Influence of 26-hydroxycholesterol on the composition and function of gel-filtered platelets. J. Am. Coll. Nutr. 10, 114-122.
34. Szostek R., Kucuk, O., Lis, LJ., Tracy, D., Mata, R., Dey, T., Kauffman, J.W., Yachnin, S. & Westerman, M.P. (1991): Effect of inserted oxysterols on phospholipid packing in normal and sickle red blood cell membranes. Biochem. Biophys. Res. Commun. 180, 730-734.
35. Warren, J.S. & Ward, P.A. (1986): Oxidative injury to the vascular endothelium. Am. J. Med. Sci. 292, 97-103.
36. Dfrup, I. & Clausen, T. (1991): Effects of magnesium and zinc deficiencies on growth and protein synthesis in skeletal muscle and the heart. Br. J. Nutr. 66, 493-504.
37. Schwartz, R., Woodcock, M.A., Blakely, S.D., Wong, F.L. & Khavrallah, E.A. (1970): Effect of magnesium in growing rats on synthesis of liver protein and serum albumin. J. Nutr. 97, 123-128.
38. Gunther, T. & Averdunk, R. (1976): Action of the 'Ca-ionophore' X-537A on the electrolyte content and metabolism of Yoshida ascites tumor cells: a model for the analysis of magnesium deficiency. J. Clin. Chem. Clin. Biochem. 14, 365-371.
39. Reyes, A.J. & Leary, W.P. (1984): A formal method for the therapeutic classification of antihypertensive diuretics. Magnes. Bull. 3, 87-99.
40. 2+ deficiency. In: Magnesium in health and disease, eds M. Cantin & MS. Seelig, pp. 57-65. New York: Spectrum Publication Inc.
41. Tongyai, S., Rayssiguier, Y., Motta, C., Gueux, E., Maurois, P. & Heaton, F.W. (1989): Mechanism of increased erythrocyte membrane fluidity during magnesium deficiency in weanling rats. Am. J. Physiol. 257, C270-C276.
42. Gould, R.J. & Ginsberg, B.H. (1985): Membrane fluidity and membrane receptor function: In: Membrane fluidity in biology. Vol. 3, pp. 257-277. New York: Academic Press.
43. Rayssiguier, Y., Gueux, E. & Motta, C. (1989): Evidence for a membrane modification in magnesium nutritional deficiency in the rat: fluorescence polarization study. Biomemb. Nutr. 195, 441-452.