SSA/Ro antigen expressed on membrane of UVB-induced apoptotic keratinocytes is pathogenic but not detectable in supernatant of cell culture

Chinese Medical Journal

Volumn 112, Issue 6, 1999, Pages 512-515

  Wang, Baoxi ^a   Dong, Xiuqing ^a   Yuan, Zhaozhuang ^a   Zuo, Yagang ^a   Wang, Jiabi ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

Apoptosis; Keratinocytes; SSA Ro; Ultraviolet B

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; RIBONUCLEOPROTEIN; SMALL CYTOPLASMIC RNA; SS A ANTIGEN; SS-A ANTIGEN; SSA2 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL MEMBRANE; CYTOLOGY; HUMAN; IMMUNOLOGY; KERATINOCYTE; METABOLISM; NEWBORN; ULTRAVIOLET RADIATION;

APOPTOSIS; AUTOANTIBODIES; AUTOANTIGENS; CELL MEMBRANE; CELLS, CULTURED; HUMANS; INFANT, NEWBORN; KERATINOCYTES; RIBONUCLEOPROTEINS; RNA, SMALL CYTOPLASMIC; ULTRAVIOLET RAYS;

EID: 0033140288     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Boyce ST, Ham RG. Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture. J Invest Dermatol 1983;81:33s-40s.
2. Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994;179:1317-1330.
3. LeFeber WP, Norris DA, Ryan SR, et al. Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes. J Clin Invest 1984;74:1545-1551.
4. Jones SK. Ultraviolet radiation (UVR) induces cell-surface Ro/SSA antigen expression by human keratinocytes in vitro: a possible mechanism for the UVR induction of cutaneous lupus lesions. Br J Dermatol 1992;126:546-553.
5. Lee LA, Weston WL, Krueger GG, et al. An animal model of antibody binding in cutaneous lupus. Arthritis Rheum 1986;29:782-788.