Differential 18F-2-deoxyglucose uptake in viable dysfunctional myocardium with normal resting perfusion: Evidence for chronic stunning in pigs

Circulation

Volumn 99, Issue 21, 1999, Pages 2798-2805

  Fallavollita, James A ^a,b   Canty Jr , John M ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Fluorodeoxyglucose; Hibernation; Stunning, myocardial

Indexed keywords

FLUORODEOXYGLUCOSE F 18; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ARTICLE; CORONARY ARTERY BLOOD FLOW; DRUG UPTAKE; HEART MUSCLE PERFUSION; HIBERNATION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; SWINE; ANIMAL; CORONARY ARTERY DISEASE; PHYSIOLOGY; STUNNED HEART MUSCLE;

ANIMALS; CORONARY CIRCULATION; CORONARY DISEASE; FLUORODEOXYGLUCOSE F18; HIBERNATION; MYOCARDIAL STUNNING; RADIOPHARMACEUTICALS; SWINE;

EID: 0033137306     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.99.21.2798     Document Type: Article

References (24)

1. Kloner RA, Bolli R, Marban E, Reinlib L, Braunwald E. Medical and cellular implications of stunning, hibernation, and preconditioning: an NHLBI workshop. Circulation. 1998;97:1848-1867.
2. Armstrong WF. "Hibernating" myocardium: asleep or part dead? J Am Coll Cardiol. 1996;28:530-535.
3. Camici PG, Wijns W, Borgers M, De Silva R, Ferrari R, Knuuti J, Lammertsma AA, Liedtke AJ, Paternostro G, Vatner SF. Pathophysiological mechanisms of chronic reversible left ventricular dysfunction due to coronary artery disease (hibernating myocardium). Circulation. 1997; 96:3205-3214.
4. 18F-2-deoxyglucose deposition and regional flow in pigs with chronically dysfunctional myocardium: evidence for transmural variations in chronic hibernating myocardium. Circulation. 1997;95:1900-1909.
5. Mills I, Fallon JT, Wrenn D, Sasken H, Gray W, Bier J, Levine D, Berman S, Gilson M, Gewirtz H. Adaptive responses of coronary circulation and myocardium to chronic reduction in perfusion pressure and flow. Am J Physiol. 1994;266:H447-H457.
6. Canty JM Jr, Klocke FJ. Reductions in regional myocardial function at rest in conscious dogs with chronically reduced regional coronary artery pressure. Circ Res. 1987;61(suppl II):II-107-II-116.
7. Shen Y-T, Vatner SF. Mechanism of impaired myocardial function during progressive coronary stenosis in conscious pigs: hibernation versus stunning? Circ Res. 1995;76:479-488.
8. Sheehan FH, Schofer J, Mathey DG, Kellett MA, Smith H, Bolson EL, Dodge HT. Measurement of regional wall motion from biplane contrast ventriculograms: a comparison of the 30 degree right anterior oblique and 60 degree left anterior oblique projections in patients with acute myocardial infarction. Circulation. 1986;74:796-804.
9. McFalls EO, Baldwin D, Palmer B, Marx D, Jaimes D, Ward HB. Regional glucose uptake within hypoperfused swine myocardium as measured by positron emission tomography. Am J Physiol. 1997;272: H343-H349.
10. Marinho NVS, Keogh BE, Costa DC, Lammertsma AA, Ell PJ, Camici PG. Pathophysiology of chronic left ventricular dysfunction: new insights from the measurement of absolute myocardial blood flow and glucose utilization. Circulation. 1996;93:737-744.
11. Gerber BL, Vanoverschelde J-LJ, Bol A, Michel C, Labar D, Wijns W, Melin JA. Myocardial blood flow, glucose uptake, and recruitment of inotropic reserve in chronic left ventricular ischemic dysfunction: implications for the pathophysiology of chronic myocardial hibernation. Circulation. 1996;94:651-659.
12. Vanoverschelde J-LJ, Wijns W, Depré C, Essamri B, Heyndrickx GR, Borgers M, Bol A, Melin JA. Mechanisms of chronic regional postischemic dysfunction in humans: new insights from the study of noninfarcted collateral-dependent myocardium. Circulation. 1993;87:1513-1523.
13. Mäki M, Luotolahti M, Nuutila P, Iida H, Voipio-Pulkki L-M, Ruotsalainen U, Haaparanta M, Solin O, Hartiala J, Härkönen R, Knuuti J. Glucose uptake in the chronically dysfunctional but viable myocardium. Circulation. 1996;93:1658-1666.
14. Canty JM Jr, Fallavollita JA. Hibernating myocardium represents a primary downregulation of regional myocardial oxygen consumption distal to a critical coronary stenosis. Basic Res Cardiol. 1995;90:5-8.
15. Tillisch J, Brunken R, Marshall R, Schwaiger M, Mandelkern M, Phelps M, Schelbert H. Reversibility of cardiac wall-motion abnormalities predicted by positron tomography. N Engl J Med. 1986;314:884-888.
16. Conversano A, Walsh JF, Geltman EM, Perez JE, Bergmann SR, Gropler RJ. Delineation of myocardial stunning and hibernation by positron emission tomography in advanced coronary artery disease. Am Heart J. 1996;131:440-450.
17. Heyndrickx GR, Baig H, Nellens P, Leusen I, Fishbein MC, Vatner SF. Depression of regional blood flow and wall thickening after brief coronary occlusions. Am J Physiol. 1978;234:H653-H659.
18. Homans DC, Sublett E, Dai X-Z, Bache RJ. Persistence of regional left ventricular dysfunction after exercise-induced myocardial ischemia. J Clin Invest. 1986;77:66-73.
19. Folts JD, Gallagher K, Rowe GG. Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation? Circulation. 1982;65:248-255.
20. Gallagher KP, Osakada G, Kemper WS, Ross J Jr. Cyclical coronary flow reductions in conscious dogs equipped with ameroid constrictors to produce severe coronary narrowing. Basic Res Cardiol. 1993;80: 100-106.
21. 18F-fluorodeoxyglucose in postischemic myocardium of patients with exercise-induced angina. Circulation. 1986;74:81-88.
22. 18F-FDG uptake in the fasting state and coronary angiography in patients with coronary artery disease. Nucl Med Commun. 1994;15:311-316.
23. Kalff V, Schwaiger M, Nguyen N, McClanahan TB, Gallagher KP. The relationship between myocardial blood flow and glucose uptake in ischemic canine myocardium determined with fluorine-18-deoxyglucose. J Nucl Med. 1992;33:1346-1353.
24. 18F]2-deoxy-2-fluoro-D-glucose for assessing myocardial glucose uptake. Circulation. 1995;91:2435-2444.