Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase ε

Biochemical Journal

Volumn 339, Issue 3, 1999, Pages 657-665

  Huang, Deqi ^a   Pospiech, Helmut ^a   Kesti, Tapio ^a,b   Syväoja, Juhani E ^a  

^a UNIVERSITY OF OULU   (Finland)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Alternative splicing; Gene structure; Non conforming splice site

Indexed keywords

ADENOSINE; CELL NUCLEUS DNA; DNA POLYMERASE; MESSENGER RNA; SIGNAL PEPTIDE; THYMIDINE; TRANSCRIPTION FACTOR;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL CYCLE S PHASE; CPG ISLAND; DNA BINDING; DNA REPAIR; DNA REPLICATION; ENZYME ACTIVE SITE; GENE EXPRESSION REGULATION; GENE SEQUENCE; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYADENYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION;

3' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; BASE SEQUENCE; CATALYTIC DOMAIN; CELL LINE; CHROMOSOMES, HUMAN, PAIR 12; CLONING, MOLECULAR; CODON, INITIATOR; CPG ISLANDS; DNA POLYMERASE II; EXONS; GENE DOSAGE; GENE LIBRARY; HELA CELLS; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; POLY A; RESPONSE ELEMENTS; RNA, MESSENGER; TATA BOX;

ANIMALIA;

EID: 0033136582     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3390657     Document Type: Article

References (54)

1. Wang, T. S.-F. (1996) DNA Replication in Eukaryotic Cells (DePamphilis, M. L., ed.), pp. 461-493, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
2. Gibbs, P. E., McGregor, W. G., Maher, V. M., Nisson, P. and Lawrence, C. W. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 6876-6880
3. Sugino, A. (1995) Trends Biochem. Sci. 20, 319-323
4. Zlotkin, T., Kaufmann, G., Jiang, Y., Lee, M. Y. W., Uitto, L., Syväoja, J. E., Dornreiter, I., Fanning, E. and Nethanel, T. (1996) EMBO J. 15, 2298-2305
5. Waga, S. and Stillman, B. (1994) Nature (London) 369, 207-212
6. Nishida, C., Reinhard, P. and Linn, S. (1988) J. Biol. Chem. 263, 501-510
7. Aboussekhra, A., Biggerstaff, M., Shivji, M. K., Vilpo, J. A., Moncollin, V., Podust, V. N., Protic, M., Hübscher, U., Egly, J. M. and Wood, R. D. (1995) Cell 80, 859-868
8. Jessberger, R., Podust, V., Hübscher, U. and Berg, P. (1993) J. Biol. Chem. 268, 15070-15079
9. Jessberger, R., Chui, G., Linn, S. and Kemper, B. (1996) Mutat. Res. 350, 217-227
10. Kamel, D., Mackey, Z. B., Sjöblom, T., Walter, C. A., McCarrey, J., Uitto, L., Palosaari, H., Lähdetie, J., Tomkinson, A. and Syväoja, J. E. (1997) Biol. Reprod. 57, 1367-1374
11. Syväoja, J. E. and Linn, S. (1989) J. Biol. Chem. 264, 2489-2497
12. Kesti, T., Frantti, H. and Syväoja, J. E. (1993) J. Biol. Chem. 268, 10238-10245
13. Li, Y., Asahara, H., Patel, V. S., Zhou, S. and Linn, S. (1997) J. Biol. Chem. 272, 32337-32344
14. Jokela, M., Mäkiniemi, M., Lehtonen, S., Szpirer, C., Hellman, U. and Syväoja, J. E. (1998) Nucleic Acids Res. 26, 730-734
15. Kesti, T. and Syväoja, J. E. (1991) J. Biol. Chem. 266, 6336-6341
16. Uitto, L., Halleen, J., Hentunen, T., Höyhtyä, M. and Syväoja, J. E. (1995) Nucleic Acids Res. 23, 244-247
17. Navas, T. A., Zhou, Z. and Elledge, S. J. (1995) Cell 80, 29-39
18. Wahl, A. F., Geis, A. M., Spain, B. H., Wong, S. W., Korn, D. and Wang, T. S.-F. (1988) Mol. Cell. Biol. 8, 5016-5025
19. Hao, H., Jiang, Y., Zhang, S. J., Zhang, P., Zeng, R. X. and Lee, M. Y. W. T. (1992) Chromosoma 102, S121-S127
20. Tuusa, J., Uitto, L. and Syväoja, J. E. (1995) Nucleic Acids Res. 23, 2178-2183
21. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. and Struhl, K. (1989) Current Protocols in Molecular Biology, Wiley Interscience, New York
22. Salles, F. J., Darrow, A. L., O'Connell, M. L. and Strickland, S. (1992) Genes Dev. 3, 803-815
23. Szpirer, J., Pedeutour, F., Kesti, T., Syväoia, J. E., Turc-Carel, C. and Szpirer, C. (1994) Genomics 20, 223-226
24. Gardiner-Garden, M. (1987) J. Mol. Biol. 196, 261-282
25. Quandt, K., Frech, K., Karas, H., Wingender, E. and Werner, T. (1995) Nucleic Acids Res. 23, 4878-4884
26. Gronostajski, R. M., Adhya, S., Nagata, K., Guggenheimer, R. A. and Hurwitz, J. (1985) Mol. Cell. Biol. 5, 964-971
27. Slansky, J. E. and Farnham, P. J. (1996) BioEssays 18, 55-62
28. Chang, Z. F. and Liu, C. J. (1994) J. Biol. Chem. 269, 17893-17898
29. Filatov, D. and Thelander, L. (1995) J. Biol. Chem. 270, 25239-25243
30. Zeng, Y. X., Somasundaram, K. and el-Deiry, W. S. (1997) Nat. Genet. 15, 78-82
31. Hu, Y. F., Luscher, B., Admon, A., Mermod, N. and Tjian, R. (1990) Genes Dev 4, 1741-1752
32. Foletta, V. J. (1996) Immunol. Cell. Biol. 74, 121-133
33. Prestridge, D. S. (1995) J. Mol. Biol. 249, 923-932
34. Reese, M. G., Harris, N. L. and Eeckman, F. H. (1996) Pac. Symp. Biocomput., Abstract
35. Chyan, Y. J., Ackerman, S., Shepherd, N. S., McBride, O. W., Widen, S. G., Wilson, S. H. and Wood, T. G. (1994) Nucleic Acids Res. 22, 2719-2725
36. Chyan, Y. J., Strauss, P. R., Wood, T. G. and Wilson, S. H. (1996) DNA Cell Biol. 15, 653-659
37. Nowak, R., Bieganowski, P., Konopinski, R. and Siedlecki, J. A. (1996) Int. J. Cancer 68, 199-202
38. He, F., Narayan, S. and Wilson, S. H. (1996) Biochemistry 35, 1775-1782
39. Larsen, F., Gundersen, G., Lopez, R. and Prydz, H. (1992) Genomics 13, 1095-1107
40. Cross, S. H. and Bird, A. P. (1995) Curr. Opin. Genet. Dev. 5, 309-314
41. Antequera, F., Boyes, J. and Bird, A. (1990) Cell 62, 503-514
42. Johnson, L. F. (1992) Curr. Opin. Cell Biol. 4, 149-154
43. Pearson, B. E., Nasheuer, H.-P. and Wang, T. S.-F. (1991) Mol. Cell. Biol. 11, 2081-2095
44. Chang, L.-S., Zhao, L., Zhu, L., Chen, M.-L. and Lee, M. Y. W. T. (1995) Genomics 28, 411-419
45. Zhao, L. and Chang, L.-S. (1996) J. Biol. Chem. 272, 4869-4882
46. Jackson, I. J. (1991) Nucleic Acids Res 19, 3795-3798
47. Aebi, M., Hornig, H. and Weissmann, C. (1987) Cell 50, 237-246
48. Chen, I.-T. and Chasin, L. A. (1993) Mol. Cell. Biol. 13, 289-300
49. Shapiro, M. B. and Senapathy, P. (1987) Nucleic Acids Res. 15, 7155-7174
50. Wahle, E. and Keller, W. (1996) Trends Biochem. Sci. 21, 247-250
51. Hook, A. G. and Kellems, R. E. (1988) J. Biol. Chem. 263, 2337-2343
52. Xiong, Y., Connolly, T., Futcher, B. and Beach, D. (1991) Cell 65, 691-699
53. Wahle E. and Keller, W. (1992) Annu. Rev. Biochem. 61, 419-440
54. Richter, J. D. (1996) in Translational Control (Hershey, J. W. B., Mathews, M. and Sonenberg, N., eds.), pp. 481-503, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY