Male reproductive effects of solvent and fuel exposure during aircraft maintenance

Reproductive Toxicology

Volumn 13, Issue 3, 1999, Pages 155-166

  Lemasters, Grace Kawas ^a,f   Olsen, Donna M ^a   Yiin, James H ^a   Lockey, James E ^a   Shukla, Rakesh ^a   Selevan, Sherry G ^b   Schrader, Steve M ^c   Toth, Greg P ^b   Evenson, Donald P ^d   Huszar, Gabor B ^e  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c UNIVERSITY OF SOUTH DAKOTA   (United States)

^d YALE UNIVERSITY   (United States)

^e NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^f UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Aircraft maintenance; Breath analysis; Fuels; Male reproduction; Mixtures; Painters; Solvents; Sperm

Indexed keywords

1,1,1 TRICHLOROETHANE; 2 BUTANONE; BENZENE; CREATINE KINASE; DICHLOROMETHANE; FUEL; PETROLEUM; SOLVENT; TOLUENE; XYLENE;

ADULT; AIR FORCE; AIRCRAFT; ARTICLE; AVIATION; BREATH ANALYSIS; CLINICAL TRIAL; CYTOLOGY; DEMOGRAPHY; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENZYMOLOGY; HUMAN; INDUSTRIAL HYGIENE; LIFESTYLE; MALE; MALE GENITAL SYSTEM; METABOLISM; OCCUPATIONAL EXPOSURE; PROSPECTIVE STUDY; QUESTIONNAIRE; REPRODUCTION; REPRODUCTIVE TOXICITY; RISK FACTOR; SOLDIER; SPERM; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TIME;

ADULT; AVIATION; CREATINE KINASE; ENVIRONMENTAL MONITORING; HUMANS; MALE; MIDDLE AGED; MILITARY PERSONNEL; OCCUPATIONAL EXPOSURE; PETROLEUM; PROSPECTIVE STUDIES; QUESTIONNAIRES; REPRODUCTION; RISK FACTORS; SEMEN; SPERM COUNT; TIME FACTORS;

EID: 0033136407     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(99)00012-X     Document Type: Article

References (88)

1. Wyrobek AJ. Methods and concepts in selecting abnormal reproductive outcomes of paternal origin. Reprod Toxicol. 1993; 7(Suppl 1):3-116.
2. Haughey BP, Graham S, Baaasure J, Zielezny M, Sufrin G, Burnett WS. The epidemiology of testicular cancer in Upstate New York. Am J Epidemiology 1989;130:25-36.
3. Davis DL, Gottlieb MB, Stampnitzky JR. Reduced ratio of male to female births in several industrial countries. JAMA 279:1998; 1018-23.
4. Mocarelli P, Brambilia P, Gerthoux PM, Patterson DG, Needham LL. Change in sex ratio with exposure to dioxin. Lancet. 1996; 348:409.
5. Wyatt R, Wilson AM. Children of anesthetists. BMJ. 1973;1:675.
6. Potashnik G, Goldsmith J, Insler V. Dibromochloropropane-induced reduction of the sex-ratio in man. Andrologia. 1984;16: 213-8.
7. Goldsmith J, Potashnik G, Israeli R. Reproductive outcomes in families of DBCP-exposed men. Arch Environ Health. 1984;39: 85-9.
8. de Cock J, Heederik D, Tielemans E, et al. Off-spring sex ratio as an indicator of reproductive hazards associated with pesticides. Occup Environ Med. 1995;52:429-30.
9. Whorton MD, Haas JL, Trent L, Wong O. Reproductive effects of sodium borates on male employees: birth rate assessment. Occup Environ Med. 1994;51:761-7.
10. Potashnik G, Porath A. Dibromochloropropene (DBCP): a 17-year reassessment of testicular function and reproductive performance. J Occup Environ Med. 1995;37:1287-92.
11. Milham S. Unusual sex ratio of births to carbon setter fathers. Am J Ind Med. 1993;23:829-31.
12. Dodds L, Armson BA. Is Canada's sex ratio in decline? Can Med Assoc J. 1997;156:46-8.
13. Marcus M, Kiely J, Xu F, McGeehin M, Jackson R, Sinks T. Changing sex ratio in the United States 1969-1995. Fertil Steril. 1998;70:270-3.
14. Carlson E, Gwercman A, Keiding N, Skakkeback N. Evidence for decreasing quality of semen during past 50 years. BMJ 1992;305: 609-13.
15. Olsen GW, Bodner KM, Ramlow JM. Have sperm counts been reduced 50 percent in 50 years? A statistical model revisted. Fertil Steril. 1995;63:887-93.
16. Brake A, Krause W. Decreasing quality of semen [letter]. BMJ. 1992;305:1498.
17. Lerchi A, Nieschlag E. Decreasing sperm counts? A critical (re)view. Exp Clin Endocrinol Diabetes. 1996;104:301-7.
18. Swan SH, Elkin EP, Fenster L. Have sperm densities declined? A reanalysis of global trend data. Env Hlth Persp. 1997;105:1228-32.
19. Wixtron RN, Bisen SL. Individual and population exposures to gasoline. J Exp Anal Environ Epidemiol. 1992;2:23-78.
20. Mehlman MA. Dangerous and cancer causing properties of products and chemicals in the oil refining industry. Environmental Res. 1992;59:238.
21. Backer LC, Egeland GM, Ashley DL, et al. Exposure to regular gasoline and ethanol oxyfuel during refueling in Alaska. Env Hlth Perspective. 1997;105:850-4.
22. Nagano K, Nakayama E, Koyano M, Oobayaski H, Adachi H, Yamada T. Mouse testicular atrophy inducted by ethylene glycol monoalkyl ethers. Japanese J Indust Health. 1979;21:29-35.
23. Cheever KL, Weigel WW, Richards DE, Lal JB, Plotnick HB. Testicular effects of bis (2-methoxyetyl) ethers in the adult male rat: Equimolar dose comparison with 2-methoxyethyl and 2-ethoxyethanol. Toxicol Industrial Health. 1989;5:1099-1109.
24. Barbee SJ, Terrill JB, DeSousa DJ, Conway CC. Subchronic inhalation toxicology of ethylene glycol monethyl ether in the rat and rabbit. Environ Health Perspect. 1984;57:157-63.
25. Qudiz DJ, Zenick H, Niewenhuis RJ, McGinnis PM. Male reproductive toxicity and recovery associated with acute ethoxyethanol exposure in rats. J Toxicol Environ Health. 1984;13:763-75.
26. Ratcliffe JM, Schrader SM, Clapp DE, Halperin WE, Turner TW, Hornung RW. Semen quality in workers exposed to 2-ethoxyethanol. Br J Ind Med. 1989;46:399-406.
27. Welch LS, Schrader SM, Turner TW, Cullen MR. Effects of exposure to ethylene glycol ethers on shipyard painters: II. Male reproduction. Am J Ind Med. 1988;14:509-26.
28. Eskenazi B, Wyrobek AJ, Fenster L, et al. I. A study of the effects of perchloroethylene exposure on semen quality in dry cleaning workers. Am J Ind Med. 1991;20:575-91.
29. Morck HI, Winkel P, Gyntelberg F. Health effects of toluene exposure. Dan Med Bull. 1988;35:196-200.
30. McDonald AD, McDonald JC, Armstrong B, Cherry NM, Nolin AD, Robert D. Fathers occupation and pregnancy outcome. Br J Ind Med. 1989;46:329-33.
31. Correa A, Gray RH, Cohen R, et al. Ethylene glycol ethers and risks of spontaneous abortion and subfertility. Am J Epid. 1996; 143:707-17.
32. Taskinen H, Anttila A, Lindbohm ML, Sallmen M, Hemminki K. Spontaneous abortions and congenital malformations among the wives of men occupationally exposed to organic solvents. Scand J Work Environ Health. 1989;15:345-52.
33. Samuels SJ, McCurdy SA, Pocekay D, Hammond SK, Lissell L, Schenker MB. Fertility history of currently employed male semiconductor workers. Am J Ind Med. 1995;28:873-82.
34. Lemasters GK, Livingston GK, Lockey JE, et al. Genotoxic changes after low-level solvent and fuel exposure on aircraft maintenance personnel. Mutagenesis. 1997;12:237-43.
35. Bedford JM. The status and the state of the human epididymis. Human Reproduction Update 1994;9:2187-99.
36. Lemasters GK, Lockey JE, Olsen DM, et al. Comparison of internal dose measures of solvents in breath, blood and urine and genotoxic changes in aircraft maintenance personnel. J Drug Chem Toxicol. 22(1), 181-200, 1999.
37. National Institute for Occupational Safety and Health. NIOSH Manual of analytic methods. 3rd ed. Ed: PM Eller. DHHS Publication No. 84-100, 1984.
38. Hornung RW, Reed LD. Estimation of average concentration in the presence of nondetectable values. Appl Occup Environ Hyg. 1990;5:46-51.
39. American Conference Governmental Industrial Hygienists (ACGIH: TLV's Threshold Limit Values and biological Exposure Indices for 1988-1989, Cincinnati, Ohio, 1988.
40. Baselt RC. Biological monitoring methods for industrial chemicals. 2nd ed. Littleton, MA: PSG Publishing; 1988.
41. Lauwerys RR. Industrial chemical exposure: guidelines for biological monitoring. Davis, California, Biomedical Publications, 1983.
42. Lauwerys RR. Objectives of biological monitoring in occupational health practice. In: Aitio A, Riihimaki V, Vainio H, eds. Biological monitoring and surveillance of workers exposed to chemicals. Washington, DC: Hemisopher Publishing; 1984:3-6.
43. Brugnone FL, Perbellini L, Apostoli P. Environmental and biological monitoring of occupational methyl ethyl ketone exposure. In: Hayes AW, Schenll RC, Miaya TS, eds. Developments in the science and practice of toxicology. Amsterdam: Elsevier Science; 1983.
44. Alessio L, Berlin A, Roi R, Boni M (editors). Human Biological Monitoring of Industrial Chemicals Series: Industrial Health and Safety Series (EUR 8476). Luxembourg: Office of Official Publications of the European Communities, 1983.
45. Conkle JP, Camp BJ, Welch BE. Trace composition of human respiratory gas. Arch Environ Health. 1975;30:290-5.
46. Schrader SM, Ratcliffe JM, Turner TW, Horning RW. The use of new field methods of semen analysis in the study of occupational hazards to reproduction: the example of ethylene dibromide. JOM. 1987;29:963-6.
47. Evenson DP, Higgins PH, Grueneberg D, Ballachey BE. Flow cytometric analysis of mouse spermatogenic function following exposure to ethylnitrosourea. Cytometry. 1985;6:238-53.
48. Evenson DP, Baer RK, Jost LK, Gesch RW. Toxicity of thiotepa on mouse spermatogenesis as determined by dual-parameter flow cytometry. Toxicol Appl Pharmacol. 1986;82:151-63.
49. Evenson DP, Bear RK, Jost LK. Long term effects of triethylenemelamine exposure on mouse testis cells and sperm chromatin structure assayed by flow cytometry. Environ Mol Mutagen. 1989;14:79-89.
50. Evenson DP, Jost LK, Baer RK, Turner TW, Schrader SM. Individuality of DNA denaturation patterns in human sperm as measured by the sperm chromatin structure assay. Reprod Toxicol. 1991;5:115-125.
51. Huszar G, Vigue L, Corrales M. Sperm creatine phosphokinase activity as a measure of sperm quality in normospermic, variablespermic, and oligospermic men. Biol Reprod. 1988;38: 1061-6.
52. Huszar G, Vigue L, Morshedi M. Sperm creatine phosphokinase m-isoform ratios and fertilizing potential of men: a blinded study of 84 couples treated with in vitro fertilization. Fertil Steril. 1992;67:882-8.
53. Huszar G, Vigue L. Correlations between the rate of lipid peroxidation and cellular maturity as measured by creatine kinase activity in human spermatozoa. J Androl. 1994;15:71-7.
54. Schrader SM, Turner TW, Breitenstein MJ, Simon SD. Longitudinal study of semen quality of unexposed workers. I. Study overview. Reprod Toxicol. 1988;2:183-90.
55. Cohen J. Statistical power analysis for the behavioral sciences. New York: Academic Press; 1977:273-403.
56. Biglow PL, Jarrell J, Young MR, Keefe TJ, Love EJ. Association of semen quality and occupational factors: comparison of case-control analysis and analysis of continuous variables. Fertil Steril. 1998;69:11-18.
57. Winer BJ. Statistical principles in experimental design, 2nd ed. New York: McGaw-Hill; 1971.
58. Bonde JP. The risk of male subfecundity attributable to welding of metals. Int J Androl. 1993;16(Suppl):1-29.
59. Larsen SB, Abell A, Bonde JP. Selection bias in occupational sperm studies. Am J Epid. 1998;147:681-5.
60. World Health Organization (WHO) laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 3rd ed. New York: Cambridge University Press; 1992 (92-13650 CIP).
61. Schrader SM, Turner TW, Simon SD. Longitudinal study of semen quality of unexposed workers: sperm motility characteristics. J Andrology. 1991;12:126-31.
62. Littell RC, Milliken GA, Stroup WW, Wolfinger RD. SAS system for mixed models. Carp, NC: SAS Institute, 1996; 87-134.
63. Schrader SM, Turner TW, Simon SD. Longitudinal study of semen quality of unexposed workers: sperm head morphometry. J Andrology. 1990;11:32-9.
64. Savitz DA, Olshan AF. Multiple comparisons and related issues in the interpretation of epidemiologic data. Am J Epidem 1995;142: 904-8.
65. Savitz DA, Olshan AF. Describing data requires no adjustment for multiple comparisons: A reply from Savitz and Olshan. Am J Epidem 1998;147:813-4.
66. Cole P. The evolving case-control study. J Chronic Dis. 1979;32: 15-27.
67. Rothmen KJ. No adjustments are needed for multiple comparisons. Epidemiology 1990;1:43-6.
68. Bross ID. Why proof of safety is much more difficult than proof of hazard. Biometrics. 1985;41:785-93.
69. Albert RG, Shukla R. The use of statistical insignificance in the formulation of risk-based standards for carcinogens. In: Comparative Environmental Risk Assessment. Ed: Cothern ER, ed. 1992: Lewis Publishers, 199-208.
70. Jouannet P, Ducot B, Feneux D, Spira A. Male factors and the likelihood of pregnancy in infertile couples. I. Study of sperm characteristics. Int J Androl. 1988;11:379-94.
71. Bongso TA, Ng SC, Mok H, et al. Effect of sperm motility on human in vitro fertilization. Arch Androl. 1989;22:185-90.
72. Donnelly ET, Lewis SE, McNally JA, Thompson W. In vitro fertilization and pregnancy rates: The influence of sperm motility and morphology on IVF outcome. Fertil Steril. 1998; 70:305-14.
73. Bostofte E, Serup J, Reber H. Relation between number of immobile sperm and pregnancies obtained during a 20 year follow-up period. Andrologia. 1984;16:136-40.
74. Morrissey RE, Lamb JC, Schwetz BA, Teague JL, Morris RW. Association of sperm, vaginal cytology, and reproductive studies in Swiss CCD-1 mice. Fundam Appl Toxicol 1988;11:359-71.
75. Moorman WJ, Skaggs SR, Clark JC, et al. Male reproductive effects of lead, including species extrapolation for the rabbit model. Reprod Toxicol 1998;12:333-46.
76. Mikkelsen S, Jørgensen M, Browne E, Gyldensted C. Mixed solvent exposure and organic brain damage. A study of painters. Acta Neurol Scand Suppl 1988;118:1-143.
77. Arlien-Søborg P, Bruhn P, Gyldensted C, Melgaard B. Chronic painters' syndrome. Chronic toxic encephalopathy in house painters. Acta Neurol Scand 1979;60:149-56.
78. Gub'eran E, Usel M, Raymond L, Tissot R, Sweetnam PM. Disability, mortality, and incidence of cancer among Geneva painters and electricians: a historical prospective study. Br J Ind Med 1989;46:16-23.
79. Teschke K, Morgan MS, Checkoway H, et al. Surveillance of nasal and bladder cancer to locate sources of exposure to occupational carcinogens. Occup Environ Med 1977;54:443-51.
80. Jensen OM, Wahrendorf J, Knudsen JB, Sørensen BL. The Copenhagen case-referent study on bladder cancer. Risks among drivers, painters and certain other occupations. Scand J Work Environ Health 1987;13:129-34.
81. Miller B A, Silverman DT, Hoover RN, Blair A. Cancer risk among artistic painters. Am J Ind Med 1986;9:281-7.
82. Bethwaite PB, Pearce N, Fraser J. Cancer risks in painters: study based on the New Zealand Cancer Registry. Br J Ind Med 1990;47:742-6.
83. Silverman DT, Levin LI, Hoover RN, Hartge P. Occupational risks of bladder cancer in the United States: I. White men. J Natl Cancer Inst 1989;81:1472-80.
84. Lynge E, Anttila A, Hemminki K. Organic solvents and cancer. Cancer Causes Control 1997;8:406-19.
85. Burns PB, Swanson GM. The occupational cancer incidence surveillance study (OCISS): risk of lung cancer by usual occupation and industry in the Detroit metropolitan area. Am J Ind Med 1991;19:655-71.
86. Matanoski GM, Stockwell HG, Diamond EL, et al. A cohort mortality study of painters and allied tradesmen. Scand J Work Environ Health 1986;12:16-21.
87. Stockwell HG, Matanoski GM. A case-control study of lung cancer in painters. J Occup Med 1985;27:125-6.
88. Lerchen ML, Wiggins CL, Samet JM. Lung cancer and occupation in New Mexico. J Natl Cancer Inst 1987;79:639-45.