A simplified regimen of weekly high dose 5-fluorouracil and leucovorin as a 24-hour infusion in patients with advanced colorectal carcinoma

Cancer

Volumn 85, Issue 9, 1999, Pages 1925-1930

  Yang, Tsai Shen ^a   Hsu, Kuan Cheng ^a   Chiang, Jy Ming ^a   Tang, Reiping ^a   Chen, Jinn Shium ^a   Changchien, Chung Rong ^a   Wang, Jeng Yi ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Advanced colorectal carcinoma; High dose 5 fluorouracil; Leucovorin; Weekly 24 hour infusion

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BLOOD TOXICITY; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CARDIOTOXICITY; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CARCINOMA; DRUG EFFICACY; DRUG INFUSION; DRUG MEGADOSE; FATIGUE; FEMALE; FOOT DISEASE; GASTROINTESTINAL SYMPTOM; HAND DISEASE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; NEUROTOXICITY; PRIORITY JOURNAL;

EID: 0033135341     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19990501)85:9<1925::AID-CNCR7>3.0.CO;2-Q     Document Type: Article

References (20)

1. Kemeny N. Role of chemotherapy in the treatment of colorectal carcinoma. Semin Surg Oncol 1987;3:190-214.
2. Shah A, MacDonald W, Goldie J, Gudauskas G, Brisebois B. 5-FU infusion in advanced colorectal cancer: a comparison of three dose schedules. Cancer Treat Rep 1985;69:739-42.
3. Ardalan B, Hussein A, Sklaver L, Reddy R, Benedetto P, Sridhar S, et al. Chemotherapy (C) of advanced carcinoma (Ca) with5-fluorouracil (FU) with leucovorin (LV) [abstract]. Proc Am Soc Clin Oncol 1989;8:116.
4. Ardalan B, Chua L, Tian E, Reddy R, Sridhar K, Benedetto P, et al. A phase II study of weekly 24-hour infusion with high-dose fluorouracil with leucovorin in colorectal cancer. J Clin Oncol 1991;9:625-30.
5. Weh HJ, Dierlamm J, Hossfeld DK. Weekly therapy with folinic acid and high-dose 5-fluorouracil 24-hour infusion in previously untreated patients with metastatic colorectal carcinoma. Eur J Cancer 1994;30A(6):890-1.
6. Kohne CH, Schoffski P, Wilke H, Kaufer C, Andreesen R, Ohl U, et al. Effective biomodulation by leucovorin of high-dose infusion fluorouracil given as a weekly 24-hour infusion: results of a randomized trial in patients with advanced colorectal cancer. J Clin Oncol 1998;16:418-26.
7. Houghton JA, Williams LG, Siebold SN, Cheshire PJ, Rodman JH, Maneval DC, et al. Relationship between dose rate of [6RS] leucovorin administration, plasma concentration of reduced folates, and pools of 5, 10-methylene-tetrahydrofolate and tetrahydrofolate in human colon adenocarcinoma xerograft. Cancer Res 1990;50:3493-502.
8. Jolivet J. Role of leucovorin dosing and administration schedule. Eur J Cancer 1995;31A:1311-5.
9. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
10. Houghton JA, Williams LG, Cheshire PJ, Wainer IW, Jadaud P, Houghton PJ. Influence of dose of [6RS] leucovorin on reduced folated pools and 5-fluorouracil - mediated thymidylate synthase inhibition in human colon adenocarcinoma xenograft. Cancer Res 1990;50:3940-6.
11. Boarman DM, Allegra CJ. Intracellular metabolism of 5-formyl tetrahydrofolate in human breast and colon cell lines. Cancer Res 1992;52:36-44.
12. Borner MM, Sartor O. More is not always better: a case for low-dose leucovorin. J Clin Oncol 1993;11:382-3.
13. Ardalan B, Singh G, Silberman H. A randomized phase I and II study of short-term infusion of high-dose 5-Fluorouracil with or without N-(phosphonacetyl)-L-aspartic acid in patients with advanced pancreatic and colorectal cancers. J Clin Oncol 1988;6:1053-8.
14. Gamelin EC, Danquechin-Dorval EM, Dumesnil YF, Maillart PJ, Goudier MJ, Burtin PC, et al. Relationship between 5-fluorouracil (5-FU) dose intensity and therapeutic response in patients with advanced colorectal cancer receiving infusional therapy containing 5-FU. Cancer 1996;77:441-51.
15. Moertel CG. Clinical management of advanced gastrointestinal cancer. Cancer 1975;36:675-82.
16. The Meta-Analysis Group in Cancer. Efficacy of intravenous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 1998;16:301-8.
17. Kemeny N, Israel K, Niedzwiecki D, Chapman D, Botet J, Minsky B, et al. Randomized study of continuous infusion fluorouracil versus fluorouracil plus cisplatin in patients with metastatic colorectal cancer. J Clin Oncol 1990;8:313-8.
18. Lokich J, Bothe A, Fine N, Perri J. Phase I study of protracted venous infusion of 5-fluorouracil. Cancer 1981;48:2565-8.
19. Fraile RJ, Baker LH, Buroker TR, Horwitz J, Vaitkevicius VK. Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous and by slow infusion. Cancer Res 1980;40: 2223-8.
20. Gamelin E, Biosdron-Celle M, Delva B, Regimbeau C, Cailleux PE, Alleaume C, et al. Long-term weekly treatment of colorectal metastatic cancer with fluorouracil and leucovorin: results of a multicentric prospective trial of fluorouracil dosage optimization by pharmacokinetic monitoring in 152 patients. J Clin Oncol 1998;16:1470-8.