Conformational change of ascidiacyclamide caused by asymmetric modification for an isoleucine residue: Structural analyses of [GLY], [LEU], and [PHE]ascidiacyclamides by x-ray diffraction and NMR spectroscopy

Biopolymers

Volumn 49, Issue 6, 1999, Pages 459-469

  Doi, Mitsunobu ^a   Shinozaki, Fumiyoshi ^a   In, Yasuko ^a   Ishida, Toshimasa ^a   Yamamoto, Daisuke ^a   Kamigauchi, Miyoko ^b   Sugiura, Makiko ^b   Hamada, Yasumasa ^c   Kohda, Kohfuku ^d   Shioiri, Takayuki ^d  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^c CHIBA UNIVERSITY   (Japan)

^d NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Accessible surface area; Ascidiacyclamide; C2 symmetry; Cytotoxicity; Molecular dynamics; nmr; X ray diffraction

Indexed keywords

AMINO ACIDS; CONFORMATIONS; CRYSTAL SYMMETRY; CYTOLOGY; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYAMIDES; TOXICITY; X RAY CRYSTALLOGRAPHY;

ASCIDIACYCLAMIDE; CYTOTOXICITY;

POLYPEPTIDES;

ASCIDIACYCLAMIDE; CYCLOPEPTIDE; GLYCINE; ISOLEUCINE; LEUCINE; OCTAPEPTIDE; PHENYLALANINE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; CYTOTOXICITY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; STRUCTURE ANALYSIS; X RAY DIFFRACTION;

AMINO ACID SUBSTITUTION; ANIMALS; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; CYTOTOXINS; ISOLEUCINE; LEUKEMIA L1210; MAGNETIC RESONANCE SPECTROSCOPY; MICE; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0033135199     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(199905)49:6<459::AID-BIP4>3.0.CO;2-G     Document Type: Article

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