Glioma migration can be blocked by nontoxic inhibitors of myosin II

Cancer Research

Volumn 59, Issue 9, 1999, Pages 2076-2082

  Gillespie, G Yancey ^b   Soroceanu, Liliana ^c   Manning Jr , Timothy J ^c   Gladson, Candece L ^d   Rosenfeld, Steven S ^a  

^a The University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MYOSIN; MYOSIN LIGHT CHAIN KINASE; MYOSIN LIGHT CHAIN KINASE INHIBITOR;

ARTICLE; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CYTOSKELETON; DRUG MECHANISM; DRUG POTENCY; DRUG SPECIFICITY; DRUG TARGETING; GLIOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ALKALOIDS; AZEPINES; CARBAZOLES; CELL ADHESION; CELL MOVEMENT; CELL SURVIVAL; GLIOMA; HUMANS; INDOLES; INTEGRINS; MICROFILAMENTS; MICROSCOPY, FLUORESCENCE; MYOSIN-LIGHT-CHAIN KINASE; MYOSINS; NAPHTHALENES; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; TUMOR CELLS, CULTURED;

EID: 0033135022     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Burger, P. C., and Kleihues, P. Cytologic composition of the untreated glioblastoma with implications for evaluation of needle biopsies. Cancer (Phila.), 63: 2014-2023, 1980.
2. Liotta, L. A., and Schiffman, E. Tumour motility factors. Cancer Surv., 7: 631-652, 1988.
3. Berens, M. E., Rief, M. D., Shapiro, J. R., Haskett, D., Giese, A., Joy, A., and Coons, S. W. Proliferation and motility responses of primary and recurrent gliomas related to changes in epidermal growth factor receptor expression. J. Neuro-Oncol., 27: 11-22, 1996.
4. Chicoine, M. R., and Silbergeld, D. J. The in vitro motility of human gliomas increases with increasing grade of malignancy. Cancer (Phila.), 75: 2904-2909, 1996.
5. Chicoine, M. R., and Silbergeld, D. J. Mitogens as motogens. J. Neuro-Oncol., 35: 249-257, 1997.
6. Chicoine, M. R., Madsen, C. L., and Silbergeld, D. J. Modification of human glioma locomotion in vitro by cytokines EGF, bFGF, PDGFbb, NGF, and TNFα. Neurosurgery, 36: 1165-1171, 1995.
7. Giese, A., Loo, M. A., Rief, M. D., Tran, N., and Berens, M. E. Substrates for astrocytoma invasion. Neurosurgery, 37: 294-302, 1995.
8. Giese, A., Rief, M. D., Loo, M. A., and Berens, M. E. Determinants of human astrocytoma migration. Cancer Res., 54: 3897-3904, 1994.
9. Giese, A., Loo, M. A., Tran, N., Haskett, D., Coons, S. W., and Berens, M. E. Dichotomy of astrocytoma migration and proliferation. Int. J. Cancer, 67: 275-282, 1996.
10. Endow, S. A., and Titus, M. A. Genetic approaches to molecular motors. Annu. Rev. Cell Biol., 8: 29-66, 1992.
11. Tan, J. L., Ravid, S., and Spudich, J. A. Control of non-muscle myosins by phosphorylation. Annu. Rev. Biochem., 81: 721-759, 1992.
12. Baorto, D. M., Mellado, W., and Shelanski, M. Astrocyte process growth induction by actin breakdown. J. Cell Biol., 117: 357-367, 1992.
13. Choi, O. H., Adelstein, R. S., and Beaven, M. A. Secretion from rat basophilic RBL-2H3 cells is associated with diphosphorylation of myosin light chains by myosin light chain kinase as well as phosphorylation by protein kinase C. J. Biol. Chem., 269: 536-541, 1994.
14. Fujiwara, K., and Pollard, T. D. Fluorescent antibody localization of myosin in the cleavage furrow and mitotic spindle of human cells. J. Cell Biol., 71: 848-875, 1976.
15. Goeckeler, Z. M., and Wysolmerski, R. B. Myosin light chain kinase-regulated endothelial cell contraction: the relationship between isometric tension, actin polymerization, and myosin phosphorylation. J. Cell Biol., 130: 613-627, 1995.
16. Manning, T. J., Jr., Rosenfeld, S. S., and Sontheimer, H. Lysophosphatidic acid stimulates actomyosin contraction in astrocytes. J. Neurosci. Res., 53: 343-352, 1998.
17. Padmanabhan, J., and Shelanski, M. L. Process formation in astrocytes: modulation of cytoskeletal proteins. Neurochem. Res., 23: 377-384, 1998.
18. Pasternak, C., Spudich, J. A., and Elson, E. L. Capping of surface receptors and concomitant cortical tension are generated by conventional myosin. Nature (Lond.), 341: 549-551, 1989.
19. Peleg, I., Ludowyke, R. I., Beaven, M. A., and Adelstein, R. S. The role of myosin phosphorylation in RBL-2H3 cell secretion. J. Lab. Clin. Med., 120: 675-680, 1992.
20. Sellers, J. R. Regulation of cytoplasmic and smooth muscle myosin. Curr. Opin. Cell Biol., 3: 98-104, 1991.
21. Bigner, D. D., Bigner, S. H., Ponten, J., Westermark, B., Mahaley, M. S., Ruoslahti, E., Herschman, H., Eng, L. F., and Wikstrand, C. J. Heterogeneity of genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas. J. Neuropathol. Exp. Neurol., 40: 201-229, 1981.
22. 3 integrin: adhesion mechanism for transformed glial cells. J. Clin. Invest., 88: 1924-1932, 1991.
23. Gladson, C. L., Wilcox, J. N., Sanders, L., Gillespie, G. Y., and Cheresh, D. A. Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors. J. Cell Sci., 108: 947-956, 1995.
24. 3. J. Biol. Chem., 272: 2736-2743, 1997.
25. Goldman, C. K., Kim, J., Wong, W. L., King, V., Brock, T., and Gillespie, G. Y. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. Mol. Biol. Cell, 4: 121-133, 1993.
26. Tsai, J. C., Goldman, C. K., and Gillespie, G. Y. Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF. J. Neurosurg., 82: 864-873, 1995.
27. Saudek, V., Atkinson, R. A., and Pelton, J. T. Three-dimensional structure of echistatin, the smallest active RGD protein. Biochemistry, 30: 7369-7372, 1991.
28. Nakanishi, S., Kase, H., and Matsuda, Y. Assay of myosin light chain kinase activity by HPLC using a synthetic peptide as a substrate. Anal. Biochem., 195: 313-318, 1998.
29. Isemura, M., Mita, T., Satoh, K., Narumi, K., and Matomita, M. Myosin light chain kinase inhibitors ML-7 and ML-9 inhibit mouse lung carcinoma cell attachment to the fibronectin substratum. Cell Biol. Int. Rep., 5: 965-972, 1991.
30. Conti, M. A., and Adelstein, R. S. Purification and properties of myosin light chain kinases. Methods Enzymol., 196: 34-47, 1991.
31. Nakanishi, S., Yamada, K., Iwahashi, K., Kuroda, K., and Kase, H. KT5926, a potent and selective inhibitor of myosin light chain kinase. Mol. Pharmacol., 37: 482-488, 1990.
32. Marcussen, M., Overgaard-Hansen, K., and Klenow, H. Net uptake of orthophosphate in Ehrlich ascites tumor cells in the presence of purine riboside may be rate limiting for the expansion of the pool of ribonucleotides. Biochem. Biophys. Acta, 1194: 197-202, 1994.
33. Marcussen, M., and Larsen, P. J. Cell cycle-dependent regulation of cellular ATP concentration, and depolymerization of the interphase microtubular network induced by elevated cellular ATP concentration in whole fibroblasts. Cell Motil. Cytoskeleton, 35: 94-99, 1996.
34. Nagamatsu, S., Nakamichi, Y., Inoue, N., Inoue, M., Nishino, H., and Sawa, H. Rat C6 glioma cell growth is related to glucose transport and metabolism. Biochem. J., 319: 477-482, 1996.
35. Wang, Y., and Chantler, P. D. Functional analysis of individual brain myosin II isoforms through hybrid formation. FEBS Lett., 348: 244-248, 1994.
36. Burridge, K., and Chrzanowska-Wodnicka, M. Focal adhesions, contractility, and signalling. Annu. Rev. Cell Dev. Biol., 12: 463-518, 1996.
37. Goldman, J. E., and Abramson, B. Cyclic AMP-induced shape changes in astrocytes are accompanied by rapid depolymerization of actin. Brain Res., 528: 189-196, 1990.
38. DeLozanne, A., and Spudich, J. A. Disruption of Dictyostelium myosin heavy chain gene by homologous recombination. Science (Washington DC), 236: 1086-1091, 1987.
39. Knecht, D. A., and Loomis, W. F. Antisense RNA inactivation of myosin heavy chain gene expression in Dictyostelium discoideum. Science (Washington DC), 236: 1081-1085, 1987.
40. Tullio, A. N., Accili, D., Ferrans, V. J., Yu, Z. X., Takeda, K., Grinberg, A., Westphal, H., Preston, Y. A., and Adelstein, R. S. Non-muscle myosin IIB is required for normal development of the mouse heart. Proc. Natl. Acad. Sci. USA, 94: 12407-12412, 1997.
41. Kawamoto, S., and Adelstein, R. S. Chicken non-muscle myosin heavy chains: differential expression of two mRNAs and evidence for two different polypeptides. J. Cell Biol., 112: 915-924, 1991.
42. Klemke, R., Cai, S., Giannini, A. L., Gallagher, P. J., deLanerolle, P., and Cheresh, D. A. Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol., 137: 481-492, 1997.
43. Majumdar, M., Seasholtz, T. M., Goldstein, D., deLanerolle, P., and Brown, J. H. Requirement for Rho-mediated myosin light chain phosphorylation in thrombin-stimulated cell rounding and its dissociation from mitogenesis. J. Biol. Chem., 273: 10099-10106, 1998.
44. Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y., and Kaibuchi, K. Phosphorylation, and Activation of Myosin by Rho-associated Kinase (Rho-Kinase). J. Biol. Chem., 271: 20246-20249, 1996.
45. Kawamoto, S., Bengur, A. A., Sellers, J. R., and Adelstein, R. S. In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C. J. Biol. Chem., 264: 2258-2265, 1989.
46. Kolega, J. Cytoplasmic dynamics of myosin IIA and IIB: spatial "sorting" of isoforms in locomoting cells. J. Cell Sci., 111: 2085-2095, 1998.
47. Maupin, P., Phillips, C. L., Adelstein, R. S., and Pollard, T. D. Differential localization of myosin II isoenzymes in human cultured cells and blood cells. J. Cell Sci., 107: 3077-3090, 1994.
48. Wylie, S. R., Wu, P-J., Patel, H., and Chantler, P. D. A conventional myosin motor drives neurite outgrowth. Proc. Natl. Acad. Sci. USA, 95: 12967-12972, 1998.