Michael reactions of β-keto phosphonates with arylmethylenemalononitriles: The first synthesis of densely functionalized 5- diethylphosphinyl-2-amino-4H-pyrans

Heterocycles

Volumn 51, Issue 5, 1999, Pages 1137-1141

  Marco, José L ^a   Chinchón, Pilar M ^a  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 CYANO 5 DIETHYLPHOSPHINYL 4 (4 METHOXYPHENYL) 6 PHENYL 4H PYRAN; 2 AMINO 3 CYANO 5 DIETHYLPHOSPHINYL 4 (4 METHYLPHENYL) 6 PHENYL 4H PYRAN; 2 AMINO 4 (4 CHLOROPHENYL) 3 CYANO 5 DIETHYLPHOSPHINYL 6 PHENYL 4H PYRAN; 3 AMINO 3 CYANO 5 DIETHYLPHOSPHINYL 4,6 DIPHENYL 4H PYRAN; MALONONITRILE; PHOSPHONIC ACID DERIVATIVE; PYRAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; THIN LAYER CHROMATOGRAPHY;

EID: 0033133721     PISSN: 03855414     EISSN: None     Source Type: Journal    
DOI: 10.3987/com-99-8530     Document Type: Article

References (10)

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7. J. L. Marco, J. Org. Chem., 1997, 62, 6575.
8. R. Budriesi, A. Rampa, A. Bisi, G. Fabbri, A. Chiarini, and P. Valenti, Arzneim.-Forsch. Drug Res., 1996, 46, 374.
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10. Using chiral β-keto phosphonates (see, for instance: S.-K. Chung, and D.-H. Kang, Tetrahedron: Asymmetry, 1997, 8, 3027), we could prepare enantiomerically pure 2-amino-4-aryl-5-phosphinyl-4H-pyrans.