The conveyor belt hypothesis for thymocyte migration: Participation of adhesion and de-adhesion molecules

Brazilian Journal of Medical and Biological Research

Volumn 32, Issue 5, 1999, Pages 569-572

  Villa Verde, D M S ^a   Calado, T C ^a,b   Ocampo, J S P ^a,c   Silva Monteiro, E ^a   Savino, W ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Adhesion molecules; Extracellular matrix; Galectin 3; Thymic nurse cells; Thymus

Indexed keywords

STAPHYLOCOCCUS PHAGE 3A;

CELL ADHESION MOLECULE; DIFFERENTIATION ANTIGEN; GALECTIN 3;

ARTICLE; CELL DIFFERENTIATION; CELL MOTION; CYTOLOGY; EXTRACELLULAR MATRIX; PHYSIOLOGY; THYMUS;

ANTIGENS, DIFFERENTIATION; CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELL MOVEMENT; EXTRACELLULAR MATRIX; GALECTIN 3; THYMUS GLAND;

EID: 0033129824     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X1999000500010     Document Type: Article

References (25)

1. Godfrey DI & Zlotnik A (1993). Control points in early T-cell development. Immunology Today, 14: 547-553.
2. Boyd RL & Hugo P (1991). Towards an integrated view of thymopoiesis. Immunology Today, 12: 71-79.
3. von Boehmer H, The HS & Kisielow P (1989). The thymus selects the useful, neglects the useless and destroys the harmful. Immunology Today, 10: 57-61.
4. Scollay R & Godfrey DI (1995). Thymic emigration: conveyor belts or lucky dips? Immunology Today, 16: 268-273.
5. Savino W, Dardenne M & Carnaud C (1996). The conveyor belt model for intrathymic T-cell migration. Immunology Today, 17:97-98.
6. Berrih S, Savino W & Cohen S (1985). Extracellular matrix of the human thymus: immunofluorescence studies on frozen sections and cultured epithelial cells. Journal of Histochemistry and Cytochemistry, 33: 655-664.
7. Lannes-Vieira J, Dardenne M & Savino W (1991). Extracellular matrix components of the mouse thymus microenvironment. Ontogenetic studies and modulation by glucocorticoid hormones. Journal of Histochemistry and Cytochemistry, 39: 1539-1546.
8. Lannes-Vieira J, Chammas R, Villa-Verde DMS, Vannier-Santos MA, Mello-Coelho V, Souza SJ, Brentani RR & Savino W (1993). Extracellular matrix components of the mouse thymus microenvironment. III. Thymic epithelial cells express VLA6 complex that is involved in laminin-mediated interaction with thymocytes. International Immunology, 5: 1421-1430.
9. Villa-Verde DMS, Lagrota-Candido JM, Vannier-Santos MA, Chammas R, Brentani RR & Savino W (1994). Extracellular matrix components of the mouse thymus microenvironment. IV. Modulation of thymic nurse cells by extracellular matrix ligands and receptors. European Journal of Immunology, 24: 659-664.
10. Savino W & Silva-Barbosa SD (1996). Laminin/VLA-6 interactions and T cell function. Brazilian Journal of Medical and Biological Research, 29: 1209-1220.
11. Wekerle H & Ketelsen UP (1980). Thymic nurse cells-la-bearing epithelium involved in T-lymphocyte differentiation? Nature, 283: 402-404.
12. Wekerle H, Ketelsen UP & Ernst M (1980). Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: Morphological and serological characterization. Journal of Experimental Medicine, 151: 925-943.
13. Nakayama M, Wekerle H, Savino W, Dardenne M & Bach JF (1984). Production of thymulin, a thymic hormone, by cultured mouse thymic nurse cells. Program of the 6th European Immunology Meeting, Interlaken, 264 (Abstract).
14. Martens H, Malgrange B, Robert F, Charlet C, De Groote D, Heymann D, Godard A, Soulillou JP, Moonen G & Geenen V (1996). Cytokine production by human thymic epithelial cells: control by the immune recognition of the neurohypophysial self-antigen. Regulatory Peptides, 67: 39-45.
15. Faas SJ, Rothstein JL, Kreider BL, Rovera G & Knowles BB (1993). Phenotypically diverse mouse thymic stromal cell lines which induce proliferation and differentiation of hematopoietic cells. European Journal of Immunology, 23: 1201-1214.
16. Wick G, Rieker T & Penninger J (1991). Thymic nurse cells: a site for positive selection and differentiation of T cells. Current Topics in Microbiology and Immunology, 173:99-105.
17. Aguilar LK, Aguilar-Cordova E, Cartwright JJ & Belmont JW (1994). Thymic nurse cells are sites of thymocyte apoptosis. Journal of Immunology, 152: 2645-2651.
18. Hiramine C, Nakagawa T, Miyauchi A & Hojo K (1996). Thymic nurse cells as the site of thymocyte apoptosis and apoptotic cell clearance in the thymus of cyclophosphamide-treated mice. Laboratory Investigation, 75: 185-201.
19. Andrews P & Boyd RL (1985). The murine thymic nurse cell: an isolated thymic microenvironment. European Journal of Immunology, 15: 36-41.
20. Philp D, Pezzano M, Li Y, Omene C, Boto W & Guyden J (1993). The binding, internalization, and release of thymocytes by thymic nurse cells. Cellular Immunology, 148: 301-315.
21. Houben-Defresne MP, Varlet A, Goffinet G & Boniver J (1982). Thymic nurse cells are the first site of virus replication after inoculation of the radiation leukemia virus. Leukemia Research, 6: 231-241.
22. Perillo NL, Marcus ME & Baum LG (1998). Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death. Journal of Molecular Medicine, 76: 402-412.
23. Sato S & Hughes RC (1992). Binding specificity of a baby hamster kidney lectin for H type I and II chains, polylactosamine glycans, and appropriately glycosylated forms of laminin and fibronectin. Journal of Biological Chemistry, 267: 6983-6990.
24. Le Marer N & Hughes RC (1996). Effects of the carbohydrate-binding protein galectin-3 on the invasiveness of human breast carcinoma cells. Journal of Cellular Physiology, 168: 51-58.
25. Yang R-Y, Hsu DK & Liu F-T (1996). Expression of galectin-3 modulates T-cell growth and apoptosis. Proceedings of the National Academy of Sciences, USA, 93: 6737-6742.