Cytotoxic and mutagenic potencies of various root canal filling materials in eukaryotic and prokaryotic cells in vitro

Journal of Endodontics

Volumn 25, Issue 5, 1999, Pages 359-363

  Ersev, Handan ^a   Schmalz, Gottfried ^b   Bayirli, Gündüz ^a   Schweikl, Helmut ^b  

^a ISTANBUL UNIVERSITY   (Turkey)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AH 26 FILLING MATERIAL; ANTIINFLAMMATORY AGENT; BISMUTH; CALCIBIOTIC ROOT CANAL SEALER; CALCIUM HYDROXIDE; CORTICOSTEROID METHANETRIOL MIXTURE; DEXAMETHASONE; DRUG DERIVATIVE; EPOXY RESIN; FORMALDEHYDE; GLASS IONOMER; HYDROCORTISONE; KETAC ENDO; METHENAMINE; POLYMER; RESORCINOL DERIVATIVE; ROOT CANAL FILLING MATERIAL; SILVER; THYMOL; TITANIUM; TUBLISEAL; ZINC OXIDE; ZINC OXIDE EUGENOL;

ANIMAL; ARTICLE; CHEMISTRY; COMPARATIVE STUDY; DRUG COMBINATION; DRUG EFFECT; L CELL; MOUSE; MUTAGEN TESTING; SALMONELLA TYPHIMURIUM; SPAD; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; BISMUTH; CALCIUM HYDROXIDE; DEXAMETHASONE; DRUG COMBINATIONS; EPOXY RESINS; FORMALDEHYDE; GLASS IONOMER CEMENTS; HYDROCORTISONE; L CELLS (CELL LINE); METHENAMINE; MICE; MUTAGENICITY TESTS; POLYMERS; RESORCINOLS; ROOT CANAL FILLING MATERIALS; SALMONELLA TYPHIMURIUM; SILVER; THYMOL; TITANIUM; ZINC OXIDE; ZINC OXIDE-EUGENOL CEMENT;

EID: 0033128087     PISSN: 00992399     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0099-2399(06)81172-6     Document Type: Article

References (20)

1. Pumarola J, Berastegui E, Brau E, Canalda C, Jimenez de Anta T. Antimicrobial activity of seven root canal sealers. Oral Surg Oral Med Oral Pathol 1992;74:216-20.
2. Mittal M, Chandra S, Chandra S. Comparative tissue toxicity evaluation of four endodontic sealers. J Endodon 1995;21:622-4.
3. Pascon EA, Leonardo MR, Safavi K, Langeland K. Tissue reactions to endodontic materials: methods, criteria, assessment, and observations. Oral Surg Oral Med Oral Pathol 1991;72:222-37.
4. Hong YC, Wang JT, Hong CY, Brown WE, Chow LC. The periapical tissue reactions to a calcium phosphate cement in the teeth of monkeys. J Biomed Mater Res 1991;25:485-98.
5. Economides N, Kotsaki-Kovatsi VP, Poulopoulos A, Kolokuris I, Rozos G, Shore R. Experimental study of the biocompatibility of four root canal sealers and their influence on the zinc and calcium content of several tissues. J Endodon 1995;21:122-7.
6. Schmalz G. Eine Modifikation des Kaninchen-Implantations-Tests zur biologischen Prüfung von Wurzelkanalfüll-Materialien. Zahnärztl Praxis 1987; 10:366-77.
7. Kolokuris I, Beltes P, Economides N, Vlemmas I. Experimental study of the biocompatibility of a new glass-ionomer root canal sealer (Ketac-Endo). J Endodon 1996;22:395-8.
8. Meryon SD, Brook AM. In vitro comparison of the cytotoxicity of twelve endodontic materials using a new technique. Int Endod J 1990;23:203-10.
9. Beltes P, Koulaouzidou E, Kotoula V, Kortsaris AH. In vitro evaluation of the cytotoxicity of calcium hydroxide-based root canal sealers. Endod Dent Traumatol 1995;11:245-9.
10. Takahara K, Onodera A, Matsumoto K. Toxicity of root canal sealers on rat bone cells in primary culture. Endod Dent Traumatol 1990;6:200-7.
11. Orstravik D, Hongslo JK. Mutagenicity of endodontic sealers. Biomaterials 1985;6:129-32.
12. Schweikl H, Schmalz G. Evaluation of the mutagenic potential of root canal sealers using the Salmonella/microsome assay. J Mater Sci Mater Med 1991;2:181-5.
13. Schweikl H, Schmalz G, Stimmelmayr H, Bey B. Mutagenicity of AH26 in an in vitro mammalian cell mutation assay. J Endodon 1995;21:407-10.
14. Stea S, Savarino L, Ciapetti G, Stea S, Trotta F, Morozzi G, Pizzoferrato A. Mutagenic potential of root canal sealers: evaluation through Ames testing. J Biomed Mater Res 1994;28:319-28.
15. Heil J, Reifferscheid G, Waldmann P, Leyhausen G, Geurtsen W. Genotoxicity of dental materials. Mutat Res 1996;368:181-94.
16. Mossman T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65:55-63.
17. Schmalz G, Schweikl H. A semiautomated cell culture evaluation system for cytotoxicity testing of dental materials. J Mater Sci Mater Med 1990;1:228-32.
18. Canter DA, Zeiger E, Haworth S, Lawlor T, Mortelsman K, Speck W. Comparative mutagenicity of aliphatic epoxides in Salmonella. Mutat Res 1986;172:105-38.
19. Spangberg LSW, Barbosa SV, Lavigne GD. AH26 releases formaldehyde. J Endodon 1993;19:596-8.
20. Levin DE, Hollstein M, Christman MF, Schwiers EA, Ames BN. A new Salmonella tester strain (TA102) with A-T base pairs at the site of mutation detects oxidative mutagens. Proc Natl Acad Sci USA 1982;79:7445-9.