Gadolinium Chloride Inhibits Lipopolysaccharide-Induced Mortality and In Vivo Prostaglandin E2 Release By Splenic Macrophages

Journal of Gastrointestinal Surgery

Volumn 3, Issue 3, 1999, Pages 301-307

  Roland, Claude R ^a   Nakafusa, Yuji ^a   Flye, M Wayne ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BARNES JEWISH HOSPITAL   (United States)

Author keywords

Arginine; Gadolinium; Lipopolysaccharide; Prostaglandin E2; Rat; Septic mortality; Splenic macrophages

Indexed keywords

ALANINE; ANTIINFLAMMATORY AGENT; ARGININE; GADOLINIUM; GADOLINIUM CHLORIDE; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2;

ANIMAL; ARTICLE; BLOOD; CELL CULTURE; CELL PROTECTION; CELL SURVIVAL; CYTOLOGY; DOWN REGULATION; DRUG ANTAGONISM; DRUG EFFECT; ENDOTOXEMIA; INTRAVENOUS DRUG ADMINISTRATION; LIVER VEIN; MACROPHAGE; MALE; METABOLISM; PHAGOCYTOSIS; PORTAL VEIN; RAT; SECRETION; SEPSIS; SPLEEN; SPRAGUE DAWLEY RAT;

ALANINE; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARGININE; CELL SURVIVAL; CELLS, CULTURED; CYTOPROTECTION; DINOPROSTONE; DOWN-REGULATION; ENDOTOXEMIA; GADOLINIUM; HEPATIC VEINS; INJECTIONS, INTRAVENOUS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; PHAGOCYTOSIS; PORTAL VEIN; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; SPLEEN;

EID: 0033122801     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1091-255X(99)80072-9     Document Type: Article

References (42)

1. Saba TM, Physiology and pathophysiology of the reticuloendothelial system. Arch InternMed 1970;126:1031-1052.
2. Roland CR, Mangino MJ, Flye MW. Lymphocyte suppression by Kupffer cells prevents portal venous tolerance induction. Transplantation 1993;55:1151-1158.
3. Callery MP, Mangino MJ, Flye MW. A biological basis for limited Kupffer cell reactivity to portal-derived endotoxin. Surgery 1991;110:221-230.
4. Faist E, Mewes A, Strasser T, Walz A, Alkan S, Baker C, Ertel W, Heberer G. Alteration of monocyte function following major injury. Arch Surg 1987;123:287-292.
5. 2 production in severely injured patients. Arch Surg 1987;123:293-299.
6. 2 induced T lymphocyte proliferative suppression in sepsis. Infect Immun 1995;63:3101-3105.
7. Laszlo D, Ekstein DM, Lewin R, Stern KG. Biological studies on stable and radioactive rare earth compounds. I. On the distribution of lanthanum in the mammalian organism. J Natl Cancer Inst 1952;13:559-573.
8. Husztik E, Lazar G, Parducz A. Electron microscopic study of Kupffer cell phagocytosis blockade induced by gadolinium chloride, Br J Exp Pathol 1980;61:624-630.
9. Iimuro Y, Yamamoto M, Kohno H, Itakura J, Fujii H, Matsumoto Y. Blockade of liver macrophages by gadolinium chloride reduces lethality in endotoxemic rats - Analysis of mechanisms of lethality in endotoxemia. J Leukoc Biol 1994;55: 723-728.
10. Lazar G Jr, Husztik E, Lazar G. Effects of endotoxin and gadolinium chloride on acute septic peritonitis and septic shock in rats. In Schlag G, Redl H, eds. First Vienna Shock Forum, Part B: Monitoring and Treatment of Shock. Progress in Clinical and Biological Research, vol 236B. New York: Alan R Liss, 1987, pp 323-328.
11. Lazar G Jr, Lazar G, Kaszaki J, Olah J, Kiss I, Husztik E. Inhibition of anaphylactic shock by gadolinium chloride-induced Kupffer cell blockade. Agents Actions 1994;41:C97-C98.
12. Sax HC, Hasselgren PO, Talamini MA, Edwards LL, Fischer JE. Amino acid uptake in isolated, perfused liver: Effect of trauma and sepsis. J Surg Res 1988;45:50-55.
13. Albina JE, Caldwell MD, Henry WL Jr, Mills CD. Regulation of macrophage functions by L-arginine. J Exp Med 1989;169:1021-1029.
14. Ertel W, Morrison MH, Ayala A, Perrin MM, Chaudry IH. Blockade of prostaglandin production increases cachectin synthesis and prevents depression of macrophage functions after hemorrhagic shock. Ann Surg 1991;213:265-271.
15. Hardonk MJ, Dijkhuis FWJ, Hulstaert CE, Koudstaal J. Heterogeneity of rat liver and spleen macrophages in gadolinium chloride-induced elimination and repopulation. J Leukoc Biol 1992;52:296-302.
16. Mizgerd JP, Molina RM, Stearns RC, Brain JD, Warner AE. Gadolinium induces macrophage apoptosis. J Leukoc Biol 1996;59:189-195.
17. Roland CR, Mangino MJ, Flye MW. Lanthanide "blockade" of antigen-presenting cells suppresses lymphocyte proliferation by inducing nitric oxide synthesis. J Surg Res 1993;54:401-410.
18. Rai RM, Zhang JX, Clemens MG, Diehl AM. Gadolinium chloride alters the acinar distribution of phagocytosis and balance between pro- and ana-inflammatory cytokines. Shock 1996;4:243-247.
19. Rai RM, Yang SQ, McClain C, Karp CL, Klein AS, Diehl AM. Kupffer cell depletion by gadolinium chloride enhances liver regeneration after partial hepatectomy in rats. Am J Physiol 1996;270:G909-G918.
20. Saad B, Frei K, Scholl FA, Fontana A, Maier P. Hepatocyte-derived interleukin-6 and tumor necrosis factor-α mediate the lipopolysaccharide-induced acute-phase response and nitric oxide release by cultured rat hepatocytes. Eur J Biochem 1995;229:349-355.
21. Marano MA, Fong Y, Moldawar LL, Wei H, Calvano SE, Tracey KJ, Barie PS, Manogue K, Cerami A, Shires GT, Lowry SF. Serum cachectin/tumor necrosis factor in critically ill patients with burns correlates with infection and mortality. Surg Gynecol Obstet 1990;170:32-38.
22. Ayala A, O'Neill PJ, Uehele SA, Herdon CD, Chaudry IH. Mechanism of splenic immunosuppression during sepsis: Key role of Kupffer cell mediators. J Trauma 1997;42:882-888.
23. 2 in immune suppression following injury. Ann Surg 1991;214:253-262.
24. Schirmer WJ, Schirmer JM, Townsend MC, Fry DE. Effects of ibuprofen, indomethacin, and imidazole on survival in sepsis. Curr Surg 1987;44:102-105.
25. Faist E, Ertel W, Cohnert T, Huber P, Inthom D, Heberer G. Immunoprotective effects of cyclooxygenase inhibition in patients with major surgical trauma. J Trauma 1990;30:8-17.
26. Fletcher JR, Collins JN, Graves ED III, Luterman A, Williams MD, Izenberg SD, Rodning CB. Tumor necrosis factor-induced mortality is reversed with cyclooxygenase inhibition. Ann Surg 1993;217:668-675.
27. Hoffman T, Lizzio EF, Suissa J, Rotrosen D, Sullivan JA, Mandell GL, Bonvini E. Dual stimulation of phospholipase activity in human monocytes: Role of calcium-dependent and calcium-independent pathways in arachidonic acid release and eicosanoid formation. J Immunol 1988;140:3912-3918.
28. Balsinde J, Fernandez B, Diez E. Regulation of arachidonic acid release in mouse peritoneal macrophages: The role of extracellular calcium and protein kinase C. J Immunol 1990;144;4298-4304.
29. 2 formation in P388D, macrophage-like cells. BiochemJ 1994;298:543-551.
30. Hambly BD, dos Remedios CG. Responses of skeletal muscle fibres to lanthanide ions. Experientia 1977;33:1042-1044.
31. 2+ release from intracellular stores in neutrophils. J Biol Chem 1992;267:1443-1448.
32. 2+ mobilization to mechanical stretch in endothelial cells. Am J Physiol 1993;264:C1037-C1044.
33. Iyengar JE, Caldwell MD, Henry WL Jr, Mills CD. Regulation of macrophage functions by L-arginine. J Exp Med 1989;169:1021-1029.
34. Morris SM Jr. Regulation of enzymes of urea and arginine synthesis. Annu Rev Nutr 1992;12:81-101.
35. Knowles RG, Merrett M, Salter M, Moncada S. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem J 1990;270:833-836.
36. Barbul A, Lazarou SA, Efron DT. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery 1990;108:331-337.
37. Kelly E, Morris SM Jr, Billiar TR. Nitric oxide, sepsis, and arginine metabolism. J Parenter Enter Nutr 1995;19:234-238.
38. Stuehr DJ, Nathan CF. Nitric oxide: A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J Exp Med 1989;169:1543-1555.
39. Green SJ, Crawford RM, Hockmeyer JT, Meltzer MS, Nacy CA. Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-γ-stimulated macrophages by induction of tumor necrosis factor-α. J Immunol 1990;145:4290-4297.
40. Salvemini D, Settle SL, Masferrer JL, Seibert K, Currie MG, Needleman P. Regulation of prostaglandin production by nitric oxide: An in vivo analysis. Br J Pharmacol 1995;114:1171-1178.
41. Watkins DN, Garlepp MJ, Thompson PF. Regulation of the inducible cyclo-oxygenate pathway in human cultured airway epithelial (A549) cells by nitric oxide. Br J Pharmacol 1997;121:1482-1488.
42. Drapier JC, Hibbs JB Jr. Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells. J Immunol 1988;140:2829-2838.