Cysteine conjugate β-lyase activity in three species of parasitic helminth

International Journal for Parasitology

Volumn 29, Issue 4, 1999, Pages 543-548

  Adcock, Harriet J ^a   Brophy, Peter M ^b   Teesdale Spittle, Paul H ^a   Buckberry, Lorraine D ^a  

^a DE MONTFORT UNIVERSITY   (United Kingdom)

^b ABERYSTWYTH UNIVERSITY   (United Kingdom)

Author keywords

Cysteine conjugate lyase; Glutathione S transferase; Parasitic helminth; Transaminase

Indexed keywords

ALANINE; ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ASPARTIC ACID; CYSTEINE CONJUGATE; CYSTEINE CONJUGATE BETA LYASE; CYSTEINE DERIVATIVE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE TRANSFERASE; OXALOACETIC ACID; PHENYLALANINE; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; DETOXIFICATION; ENZYME ACTIVITY; ENZYME PURIFICATION; HELMINTH; NONHUMAN; PROTEIN EXPRESSION; REVIEW; XENOBIOTIC METABOLISM;

CESTODA; FASCIOLA HEPATICA; HELIGMOSOMOIDES POLYGYRUS; HEPATICA; MONIEZIA EXPANSA; NECATOR AMERICANUS; NEMATODA; VERMES;

EID: 0033119276     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(99)00022-3     Document Type: Article

References (31)

1. Gibson GG, Skett P. Introduction To Drug Metabolism, Second Edition. London: Chapman and Hall, 1994.
2. Dekant W, Vamvakas S, Anders MW. Formation and fate of nephrotoxic and cytotoxic cysteine conjugates: cysteine conjugate β-lyase pathway. In: Anders MW, Dekant W, editors. Advances in Pharmacology. Conjugation-Dependent Carcinogenicity and Toxicity Of Foreign Compounds. London: Academic Press, 1994;115-162.
3. Anders M.W., Lash L., Dekant W., Elfarra A.A., Dohn D.R. Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. CRC Crit Rev Toxicol. 18:1988;311-341.
4. Shaw PN, Blagbrough IS. Cysteine conjugate β-lyase II: Isolation, properties and structure activity relationships. In: Damani LA, editor. Sulphur Containing Drugs and Related Organic Compounds. Chichester: Ellis Horwood, 1989;135-155.
5. Buckberry L.D., Blagbrough I.S., Bycroft B.W., Shaw P.N. Bovine pulmonary, hepatic and renal tissues: models for the study of mammalian C-S lyase enzymes. Altern Lab Animal (A.T.L.A.). 21:1993;360-370.
6. Buckberry L.D., Blagbrough I.S., Bycroft B.W., Shaw P.N. Kynurenine amino transferase activity in human liver: identity with human hepatic C-S lyase and a physiological role for this enzyme. Toxicol Lett. 60:1992;241-246.
7. Buckberry L.D., Blagbrough I.S., Bycroft B.W., Shaw P.N. Human renal, hepatic and pulmonary C-S lyases: possible catalysts for the biosynthesis of toxic thiols in phase III metabolism. Pharm Sci Commun. 4:1994;107-116.
8. Brophy P.M., Barrett J. Glutathione transferase in helminths. J Parasitol. 100:1990;345-349.
9. Brophy P.M., Pritchard D.I. Parasitic helminth glutathione S-transferase: an update on their potential targets for immuno- and chemotherapy. Exp Parasitol. 79:1994;89-96.
10. Precious W.Y., Barrett J. The possible absence of cytochrome P-450 linked xenobiotic metabolism in parasitic helminths. Biochim Biophys Acta. 992:1989;215-222.
11. Brazier J.L., Riviere J.L. In vivo metabolism of aminopyrine by the larvae of the helminth Heligmosoides polygyrus. Parasitol Res. 81:1995;302-304.
12. Kotze A.C. Cytochrome P450 monooxygenase activity in Haemonchus contortus. Int J Parasitol. 27:1997;33-40.
13. Brophy P.M., Barrett J. Strategies for detoxification of aldehyde products of lipid peroxidation in helminths. Mol Biochem Parasitol. 42:1990;205-211.
14. Brophy P.M., Ben-Smith A., Brown A., Behnke J.M., Pritchard D.I. Differential expression of glutathione S-transferase (GST) by adult Heligmosomoides polygyrus during primary infection in fast and slow responding hosts. Int J Parasitol. 25:1995;641-645.
15. Dass P.D., Donahue M.J. γ-Glutamyl transpeptidase activity in Ascaris summ. Mol Biochem Parasitol. 20:1986;233-236.
16. Barrett J. Amino acid metabolism in helminths. Adv Parasitol. 30:1991;39-105.
17. Gaskin P.J., Adcock H.J., Buckberry L.D., Teesdale-Spittle P.H., Shaw P.N. The C-S lysis of L-cysteine conjugates by aspartate and alanine aminotransferase enzymes. Hum Exp Toxicol. 14:1995;422-427.
18. Brophy P.M., Ben-Smith A., Brown A., Pritchard D., Behnke J.M. Differential expression of glutathione S-transferase (GST) by adult Heligmosomoides polygyrus during primary infection in fast and slow responding hosts. Comp Biochem Mol Biol. 109B:1994;585-592.
19. Brophy P.M., Patterson L.H., Brown A., Pritchard D.I. Glutathione S-transferase (GST) expression in the human hookworm Necator americanus: potential roles for excretory-secretory forms of GST. Acta Tropica. 59:1995;259-263.
20. McKinney L.L., Picken J.C., Weakley F.B., Eldridge A.C., Campbell R.E., Cowan J.C., Biester H.E. Possible toxic factor of trichloroethylene extracted soybean oil meal. J Am Chem Soc. 81:1959;909-915.
21. Parke D.V., Williams R.T. Studies in detoxification 38: the metabolism of benzene. Biochem J. 48:1951;624-629.
22. Abbott W.A., Bridges R.J., Meister A. Extracellular metabolism of glutathione accounts for its disappearance from the basolateral circulation of the kidney. J Biol Chem. 259:1984;15393-15400.
23. Lock E.A., Ishmael J. Effect of the organic acid transport inhibitor probenecid on renal cortical uptake and proximal tubular toxicity of hexachloro-1,3-butadiene and its conjugates. Toxicol App Pharmacol. 81:1985;32-42.
24. Lash L.H., Elfarra A.A., Anders M.W. Renal cysteine conjugate β-lyase; bioactivation of nephrotoxic cysteine S-conjugates in isolated rat kidney cells. J Biol Chem. 261:1986;5930-5935.
25. Stevens J.L., Robbins J.D., Byrd R.A. A purified cysteine conjugate β-lyase from rat kidney cytosol. J Biol Chem. 261:1986;15529-15537.
26. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J Biol Chem. 193:1951;265-275.
27. Gutmann I, Wahlefeld AW. L(+)-Lactate: determination with lactate dehydrogenase and NAD. In: Bergmeyer HU, editor. Methods of Enzymatic Analysis. New York: Academic Press, 1974;1464-1472.
28. Bergmeyer H.U., Scheibe P., Wahlefeld A.W. Optimisation of methods for aspartate aminotransferase and alanine aminotransferase. Clin Chem. 24:1978;58-73.
29. Cooper AJL, Meister A. Glutamine transaminase L from rat liver. In: Meister A, editor. Methods in Enzymology. London: Academic Press, 1985;338-343.
30. Orlowski M., Meister A. γ-Glutamyl-p-nitroanilide: a new convenient substrate for determination and study of L- and D-γ-glutamyl transpeptidase activities. Biochim Biophys Acta. 73:1963;679-681.
31. Cooper AJL, Meister A. Glutamine transaminase L from rat liver. In: Meister A, editor. Methods in Enzymology. London: Academic Press, 1985;344-349.