The toxicology of 1,2-dibromo-3-chloropropane (DBCP): A brief review

International Journal of Occupational and Environmental Health

Volumn 5, Issue 2, 1999, Pages 122-126

  Teitelbaum, Daniel Thau ^a,b,c  

^a Department of Geology and Geological Engineering   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c NONE   (United States)

Author keywords

1,2 Dibromo 3 chloropropane; Azoospermia; Oligospermia; Pesticides; Reproductive health; Spermatogenicity; Sterility

Indexed keywords

1,2 DIBROMO 3 CHLOROPROPANE; 1,2-DIBROMO-3-CHLOROPROPANE; ANTINEMATODAL AGENT; CARCINOGEN; DRUG DERIVATIVE; INSECTICIDE; MUTAGENIC AGENT; PROPANE;

ANIMAL; CHEMICALLY INDUCED DISORDER; FEMALE; FEMALE INFERTILITY; HUMAN; MALE; OLIGOSPERMIA; REVIEW;

ANIMALS; ANTINEMATODAL AGENTS; CARCINOGENS; FEMALE; HUMANS; INFERTILITY, FEMALE; INSECTICIDES; MALE; MUTAGENS; OLIGOSPERMIA; PROPANE;

EID: 0033114162     PISSN: 10773525     EISSN: None     Source Type: Journal    
DOI: 10.1179/oeh.1999.5.2.122     Document Type: Review

References (27)

1. Whorton D, Krauss RM, Marshall S, Milby TH. Infertility in male pesticide workers. Lancet. 1977;2(8051):1259-61.
2. Potashnik G, Ben-Aderet N, Israeli R, Yanai-Inbar I, Sober I. Suppressive effect of 1,2-dibromo-3-chloropropane on human spermatogenesis. Fertil Steril. 1978;30:444-7.
3. Ramirez-R AL, Ramirez-M CM. Male sterility caused by occupational exposure to the nematocide, 1,2-dibromo-3-chloropropane. Acta Med Cosit. 1980;23:219-22.
4. Lipschultz LJ, Ross CE, Whorton D, Milby T, Smith R, Joyner RE. Dibromochloropropane and its effect on testicular function in man. J Urol. 1980;124:464-8.
5. Legator MS. Chronology of studies regarding toxicity of 1,2-dibromo-3-chloropropane. Ann NY Acad Sci. 1979;329:331-8.
6. Torkelson TR, Sader SE, Rowe VK, et al. Toxicologic investigations of 1,2-dibromo-3-chloropropane. Toxicol Appl Pharmacol. 1961;3:545-59.
7. Whorton D, Milby TH, Krauss RM, Stubbs HA. Testicular function in DBCP exposed pesticide workers. J Occup Med. 1979;21:161-6.
8. Rakhmatullaev NN. Hygienic characteristics of the nematocide Nemagon in reaction to water pollution control. Hyg Sanit. 1971;36:344-8.
9. Olson WA, Habermann RT, Weisburger EK, Ward JM, WeisburgerJH. Induction of stomach cancer in rats and mice by halogenated aliphatic fumigants. J Natl Cancer Inst. 1973;51:1993-5.
10. Olsen GW, Bodner KM, Stafford BA, Cartmill JB, Gondek MR. Update of the mortality experience of employees with occupational exposure to 1,2-dibromo-3-chloropropane (DBCP). Am J Ind Med. 1995;28:399-410.
11. Wesseling C, Ahlbom A, Antich D, Rodriguez AC, Castro R. Cancer in banana plantation workers in Costa Rica. Int J Epidemiol. 1996;25:1125-31.
12. Reznik G, Reznik-Schuller H, Ward JM, Stinson SF. Morphology of nasal-cavity tumours in rats after chronic inhalation of 1,2. dibromo-3-chloropropane. BrJ Cancer. 1980;42:772-81.
13. Ruddick JA, Newsome WH. A teratogenicity and tissue distribulion study on dibromochloropropane in the rat. Bull Environ Contam Toxicol. 1979;21(4-5):483-7.
14. Rosenkranz H. Genetic activity of 1,2-dibromo-3-chloropropane a widely used fumigant. Bull Environ Contam Toxicol. 1975; 14:8-12.
15. Privai M, McCoy W, Rosenkranz A. Tris (2,3-dibromopropyl) phosphate: mutagenicity of a widely used flame retardant. Science. 1977;195:76-8.
16. Blum A, Ames B. Flame retardant additives as possible cancer hazards. Science. 1977;195:17-23.
17. Biles RW, Connor TH, Trieff NM, Legator MS. The influence of contaminants on the mutagenic activity of dibromochloropropane (DBCP). J Environ Pathol Toxicol. 1978;2:301-12.
18. Kato Y, Sato K, Harada T, Maki S, Matano O, Goto S. Correlation between macromolecular binding of DBCP-metabolite and pathogenicity of necrosis. Nippon Noyaku Gakkaishi (J Pestic Sci). 1980;5:81-8.
19. Thrupp LA. Sterilization of workers from pesticide exposure: the causes and consequences of DBCP-induced damage in Costa Rica and beyond. IntJ Health Serv. 1991;21:731-57.
20. DeMent JD. March 1978, Castle & Cooke Foods, Memo re: DBCP Safe Handling Procedures. DBCP: The Legacy. [Discovery materials from Misko, Howie & Sweeney. Dallas, Texas]
21. Whorton MD, Milby TH. Recovery of testicular function among DBCP workers. J Occup Med. 1980;22:177-9.
22. Potashnik G, Porath A. Dibromochloropropane (DBCP): a 17-year reassessment of testicular function and reproductive performance. J Occup Environ Med. 1995;37:1287-92.
23. Cortes-Gallegos V, et al. Effects of dibromochloropropane upon diurnal variations of gonadotropins and androgens. J Androl. 1980;1:277-80.
24. Goldsmith JR. Dibromochloropropane: epidemiological findings and current questions. Ann NYAcad Sci. 1997;837:300-6.
25. Teramoto S, Shirasu Y. Genetic toxicology of 1,2-dibromo-3-chloropropane (DBCP). Mutat Res. 1989;221:1-9.
26. Bjorge C, Wiger R, Holme JA, et al. DNA strand breaks in testicular cells from humans and rats following in vitro exposure to 1,2-dibromo-3-chloropropane (DBCP). Reprod Toxicol. 996;10: 51-9.
27. Kim Y, Jung K, Hwang T, et al. Hematopoietic and reproductive hazards of Korean electronic workers exposed to solvents containing 2-bromopropane [published erratum appears in ScandJ Work Environ Health 1997;23:80]. Scand J Work Environ Health. 1996;22:387-91.