Copper-nitrilotriacetate (Cu-NTA) is a potent inducer of proliferative response both in liver and kidney but is a complete renal carcinogen

International Journal of Oncology

Volumn 14, Issue 4, 1999, Pages 799-806

  Giri, Uma ^a   Iqbal, Mohammad ^a   Athar, Mohammad ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Carcinogenesis; Copper nitrilotriacetate; Hepatic and renal tumor promotion; Oxidative stress

Indexed keywords

CARCINOGEN; CUPRIC NITRILOTRIACETATE; DIETHYLNITROSAMINE; DRUG DERIVATIVE; NITRILOTRIACETIC ACID; ORGANOMETALLIC COMPOUND;

ANIMAL; ARTICLE; CELL DIVISION; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; KIDNEY TUMOR; LIVER TUMOR; MALE; MOUSE; PATHOLOGY;

ANIMALS; CARCINOGENS; CELL DIVISION; DIETHYLNITROSAMINE; KIDNEY NEOPLASMS; LIVER NEOPLASMS; MALE; MICE; NITRILOTRIACETIC ACID; ORGANOMETALLIC COMPOUNDS;

EID: 0033112105     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.14.4.799     Document Type: Article

References (45)

1. Linder MC: Nutritional Biochemistry and Metabolism. Elsevier Science, New York, 1991.
2. Bryan SE, Vizard DL, Beary DA, Lasiche RA and Hardy KJ: Partitioning of zinc and copper within subnuclear nucleoprotein particles. Nucleic Acids Res 9: 5811-5823, 1981.
3. 2. J Biol Chem 266: 20175-20184, 1991.
4. 2. J Biol Chem 266: 20185-20191, 1991.
5. Prutz WA, Butler J and Land EJ: Interaction of copper(I) with nucleic acids. Int J Radiat Biol 58: 215-234, 1990.
6. Kehrer JP: Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23: 21-48, 1993.
7. Tkeshelashvili LK, McBride T, Spence K and Loeb LA: Mutation spectrum of copper-induced DNA damage. J Biol Chem 266: 6401-6406, 1991.
8. Li Y, Togashi Y, Sato S, Emoto T, Kang JH, Takeichi N, Kobayashi H, Kojima Y, Une Y and Uchino J: Abnormal copper accumulation in non-cancerous and cancerous liver tissue of LEC rats developing hereditary hepatitis and spontaneous hepatoma. Jpn J Cancer Res 82: 490-492, 1991.
9. Sakamoto H, Sawada N, Kamimura Y, Enomoto K and Nishimura S: High sensitivity of LEC rats with chronic hepatitis to hepatocarcinogenesis: decreases in unscheduled and replicative DNA synthesis of the hepatocytes. Jpn J Cancer Res 84: 966-971, 1993.
10. Hochstein P, Kumar S and Forman SJ: Lipid peroxidation and the cytotoxicity of copper. Ann NY Acad Sci 355: 240-248, 1980.
11. Yamamoto F, Kasai H, Togashi Y, Takeichi N, Hori T and Nishimura S: Elevated levels of 8-OH-dG in DNA of liver, kidney and brain of LEC rats. Jpn J Cancer Res 84: 508-511, 1993.
12. Sokol NJ, Devereaux M, Mierau GW, Hambidge KM and Shikes RH: Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload. Gastroenterology 99: 1061-1071, 1990.
13. Toyokuni S, Okada S, Hamazaki S, Fujioka JL and Midorikawa O: Cirrhosis of the liver induced by cupric nitrilotriacetate in Wistar rats: an experimental model of copper toxicosis. Am J Pathol 134: 1263-1274, 1989.
14. Popper H, Goldfischer S, Stemlieb I, Nayak NC and Madnavan TV: Cytoplasmic copper and its toxic effects: studies in Indian childhood cirrhosis. Lancet i: 1205-1208, 1979.
15. Tsong YY and Nash HA: Effect of tarnish on copper release. Contraception 44: 385-391, 1990.
16. Toyokuni S and Sagripanti JL: Increased 8-OH-dG in kidney and liver of rats continuously exposed to copper. Toxicol Appl Pharmacol 126: 91-97, 1994.
17. Yamane Y, Sakai K, Umeda T, Murata N, Ishizeki S, Ogihara I, Takahashi A, Iwasaki I and Ide G: Suppressive effects of cupric acetate on DNA alkylation, DNA synthesis and tumorigenesis in the liver of dimethylnitrosamine treated rats. Jpn J Cancer Res 75: 1062-1069, 1984.
18. Iqbal M, Giri U and Athar M: Ferric nitrilotriacetate (Fe-NTA) is a potent hepatic tumor promoter and acts through the generation of oxidative stress. Biochem Biophys Res Commun 212: 557-563, 1995.
19. Athar M and Iqbal M: Ferric nitrilotriacetate promotes N-diethyl-nitrosamine-induced tumorigenesis in rat: implication for the involvement of oxidative stress. Carcinogenesis 19: 1133-1139, 1998.
20. Iqbal M, Sharma SD, Rezazadeh H, Hasan N, Abdulla M and Athar M: Glutathione metabolizing enzymes and oxidative stress in ferric nitrilotriacetate mediated hepatic injury. Redox Report 2: 385-391, 1996.
21. Iqbal M, Rezazadeh H, Ansar S and Athar M: α-tocopherol (vitamin-E) ameliorates ferric nitrilotriacetate-dependent renal proliferative response and toxicity: diminution of oxidative stress. Hum Exp Toxicol 17: 163-171, 1998.
22. Iqbal M and Athar M: Attenuation of iron-nitrilotriacetate-mediated renal oxidative stress, toxicity and hyperproliferative response by the prophylactic treatment of rats with garlic oil. Food Chem Toxicol 36: 485-495, 1998.
23. Umemura T, Sai K, Takagi A, Hasegawa R and Kurokawa Y: Formation of 8-hydrodeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate. Carcinogenesis 11: 345-347, 1990.
24. Pilot HC, Barsness L, Goldsworthy T and Kitagawa T: Biochemical characterization of stages of hepatocarcinogenesis after a single dose of N-diethylnitrosamine. Nature 271: 456-458, 1978.
25. Jollow DJ, Mitchell JR, Zampaglione N and Gillete JR: Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4 bromobenzeneoxide as the hepatotoxic. Intermediate Pharmacol 11: 151-169, 1974.
26. Smart RC, Huang MT and Conney AH: 1,2 diacylglycerols mimic the effects of TPA in vivo by inducing biochemical changes associated with tumor promotion in mouse epidermis. Carcinogenesis 7: 1865-1870, 1986.
27. Giles KW and Myers A: An improved diphenylamine method for the estimation of deoxyribonucleic acid. Nature 206: 93, 1965.
28. O'Brien TG, Simsimanm RC and Boutwell RK: Induction of polyamine biosynthetic enzymes in mouse epidermis by tumor promoting agents. Cancer Res 35: 1662-1670, 1975.
29. Athar M, Raza H, Bickers DR and Mukhtar H: Inhibition of BPO-mediated tumor promotion in 7,12-dimethyl benz(a)anthracene initiated skin of Sencar mice by antioxidant NDGA and DAS. J Invest Dermatol 94: 162-165, 1990.
30. Claiborne A: Catalase activity. In: CRC Handbook of Methods for Oxygen Radical Research. Greenwald RA (ed.) CRC Press, Boca Raton, FL, pp283-284, 1985.
31. Carlberg I and Mannervik B: Glutathione reductase levels in rat brain. J Biol Chem 250: 5475-5480, 1975.
32. Mohandas J, Marshall JJ, Duggin GG, Horvath JS and Tiller D: Differential distribution of glutathione and glutathione related enzymes in rabbit kidney: possible implications in analgesic neuropathy. Cancer Res 44: 5086-5091, 1984.
33. Habig WH, Pabst MJ and Jokoby WB: Glutathione-S-transferase: the first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139, 1974.
34. Athar M, Khan WA and Mukhtar H: Effect of dietary tannic acid on epidermal, lung, and forestomach polycyclic aromatic hydrocarbon metabolism and tumorigenicity in Sencar mice. Cancer Res 49: 5784-5788, 1989.
35. Lowry OH, Rosenbrough NJ, Farr AL and Randall RJ: Protein measurement with Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
36. Polio J, Enriquez RE, Chow A, Wood WM and Atterbury CE: Hepatocellular carcinoma in Wilson's disease: case report and review of the literature. J Clin Gastroenterol 11: 220-224, 1989.
37. Sugawara N, Sugawara C and Katakura M: Distribution of Cu and induction of Cu-MT in mice treated with Cu-NTA. Res Commun Chem Pathol Pharmacol 72: 97-103, 1991.
38. Wei H and Frenkel H: In vivo formation of oxidized DNA bases in tumor promoter-treated mouse skin. Cancer Res 51: 4443-4449, 1991.
39. Wei L, Wei H and Frenkel KC: Sensitivity to tumor promotion of Sencar and C57BL/6J mice correlates with oxidative events and DNA damage. Carcinogenesis 14: 841-847, 1993.
40. Kasai H, Nishimura S, Kurokawa Y and Hayashi Y: Oral administration of the renal carcinogen, potassium bromate specifically produces 8-hydroxydcguanosine in rat target organ DNA. Carcinogenesis 8: 1959-1961, 1987.
41. Akman SA, Kensler TW, Doroshow JH and Dizdaroglu M: Copper ion-mediated modification of bases in DNA in vitro by benzoyl peroxide. Carcinogenesis 14: 1971-1974, 1993.
42. Shahabuddin AR, Hadi SM, Parish JH and Ainley K: Strand scission in DNA induced by quercetin and Cu(II): role of Cu(I) and oxygen radicals. Carcinogenesis 10: 1303-1311, 1989.
43. Ahmad MS, Fazal F, Rahman A, Hadi SM and Parish JH: Activities of flavonoids for the cleavage of DNA in presence of Cu(II): correlation with the generation of active oxygen species. Carcinogenesis 13: 605-608, 1992.
44. Aruoma OI, Halliwell B, Gajewski E and Dizdaroglu M: Copper-ion-dependent damage to the bases in DNA in the presence of hydrogen peroxide. Biochem J 273: 601-604, 1991.
45. Sagripanti JL and Kraemer KH: Site-specific oxidative DNA damage at polyguanosines produced by copper plus hydrogen peroxide. J Biol Chem 264: 1729-1734, 1989.