Identification of IY81149 and its metabolites in the rat plasma using the on-line HPLC/ESI mass spectrometry

Archives of Pharmacal Research

Volumn 22, Issue 2, 1999, Pages 189-193

  Myung, Seung Woon ^a   Min, Hye Ki ^a   Jin, Changbae ^a   Kim, Myungsoo ^a   Lee, Seung Mok ^b   Chung, Gi Ju ^b   Park, Seong Jun ^b   Kim, Dong Yeon ^b   Cho, Hyun Woo ^c  

^a Korea Institute of Science and Technology   (South Korea)

^b Central Research Institute   (South Korea)

^c KyunGi University   (South Korea)

Author keywords

Collision induced dissociation (CID); Electrospray ionization (ESI); H+ K+ ATPase inhibitor; HPLC; IY81149; Mass spectrometry (MS); Metabolites

Indexed keywords

ANTIULCER AGENT; BENZIMIDAZOLE DERIVATIVE; ENZYME INHIBITOR; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; ILAPRAZOLE; SULFOXIDE;

ANIMAL; ARTICLE; BLOOD; DRUG ANTAGONISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-ULCER AGENTS; BENZIMIDAZOLES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; H(+)-K(+)-EXCHANGING ATPASE; MALE; MASS SPECTROMETRY; RATS; RATS, SPRAGUE-DAWLEY; SULFOXIDES;

EID: 0033109746     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02976545     Document Type: Article

References (10)

1. Andersson, T., Lagerstrom, P. O., Miners, J. O., Veronese, M. E., Weidolf, L. and Birkett, D. J., High-performance liquid chromatographic assay for human liver microsomal omeprazole metabolism. J. Chromatogr. B, 619, 291-297 (1993).
2. Beattie, I. G. and Blake, T. J., The structural identification of drug metabolites using thermospray liquid chromatography/mass spectrometry. Biomed. Environment. Mass Spectrom., 18, 872-877 (1989).
3. 2-receptor antagonists. Gastroenterology, 105, 963-968 (1993).
4. Hewlett-Packard, in API-Electrospray LC/MS System, User's Guide, manual part number 59987-90005, pp. 52, 1994.
5. Kim, S. U., Kim, D. Y., Chung, G. J., Hong, S. K., Park, S. J., Nam, S. H. and Lee, Y. S., United States Patent, Pat. 5,703,097, Dec. 30, 1997.
6. 18 column, J. Chromatogr. B, 579, 299-305 (1992).
7. Lindberg, P., Brandstorm, A., Wallmark, B., Mattsson, H., Rikner, L. and Hoffmann, K. J., Omeprazole : the first proton pump inhibitor. Med. Res. Rev., 10, 1-54 (1990).
8. McArthur, K. E., Collen, M. J., Maton, P. N., Cherner, J. A., Howard, J. M., Ciarleglio, C. A., Cornelius, M. J., Jensen, R. T. and Gardner, J. D., Omeprazole: effective, conbenient therapy for Zollinger-Ellison syndrome. Gastroenterology, 88, 939-944 (1985).
9. McTavish, D., Buckley, M. M. and Heel, R. C., Omeprazole. An updated review of its pharmacology and therapeutic use in acid-related disorders. Drugs, 42, 138-170 (1991).
10. 34S] omeprazole. Rapid Commun. Mass Spectrom., 6, 192-196 (1992).