HELLP syndrome: Mechanisms and management

Hospital Medicine

Volumn 60, Issue 4, 1999, Pages 243-249

  Ellison, Joanne ^a,b,c   Sattar, Naveed ^a,b,c   Greer, Ian ^a,b,c  

^a Westpoint Veterinary Group   (United Kingdom)

^b DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY   (United Kingdom)

^c NHS GREATER GLASGOW AND CLYDE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; DIAGNOSTIC ERROR; FEMALE; HELLP SYNDROME; HUMAN; LABOR INDUCTION; MATERNAL AGE; METABOLISM; MIDDLE AGED; OXIDATIVE STRESS; PATIENT EDUCATION; PREGNANCY; PREGNANCY OUTCOME; REVIEW; RISK FACTOR;

ADOLESCENT; ADULT; DIAGNOSTIC ERRORS; FEMALE; HELLP SYNDROME; HUMANS; LABOR, INDUCED; MATERNAL AGE; MIDDLE AGED; OXIDATIVE STRESS; PATIENT EDUCATION; PREGNANCY; PREGNANCY OUTCOME; RISK FACTORS;

EID: 0033109618     PISSN: 14623935     EISSN: None     Source Type: Journal    
DOI: 10.12968/hosp.1999.60.4.1089     Document Type: Article

References (38)

1. Abroug F, Boujdaria R, Nouira S et al ( 1992) Hellp syndrome: incidence and maternal fetal outcome - a prospective study. Intens Care Med 18: 274-7
2. Audibert E. Friedman SA, Frangieh AY, Sibai B (1996) Clinical utility of strict diagnostic criteria for the HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Am J Obstet Gynecol 175: 460-4
3. Barton JR, Sibai B (1996) Hepatic imaging in HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count). Am J Obstet Gvnecol 174: 1820-7
4. Brenner B, Lamr N. Thaler I (1995) HELLP syndrome associated with factor V R506Q mutation. Br J Haematol 92: 999-1001
5. Clark SL, Phelan JR, Allen SH. Golde SR (1986) Antepartum reversal of haematological abnormalities associated with the HELLP syndrome. Obstet Gynecol 31: 70-2
6. Department of Health (1998) Report on Confidential Enquiries into Maternal Deaths in the United Kingdom 1994-1996. HMSO, London
7. Endersen MJ, Lorentzen B, Henriksen T (1992) Increased lipolytic activity and high ratio of free fatty acids to albumin in sera from women with pre-eclampsia leads to triglycéride accumulation in cultured endothelial cells. Am J Obstet Gvnecol 167: 440-7
8. Hubel CA, Roberts JM, Taylor RN et al (1989) Lipid peroxidation in pre-eclampsia: new perspectives on pre-eclampsia. Am J Obstet Gynecol 161: 1025-34
9. Geary M (1997) The HELLP syndrome. Br J Obstet Gynaecol 104: 887-91
10. Goodlin RC (1982) Beware the great imitator - severe preeclampsia. Contemp Obstet Gvnaecol 20: 215
11. Kaaja R, Tikkanen M. Vinikka L, Ylikorkala 0 (1995) Serum lipoproteins, insulin and urinary prostanoid metabolites in normal and hypertensive women. Obstet Gvnecol 85: 353-6
12. Knapen MCFM. Mulder TPJ, Bisseling JGA, Penders RHMJ, Peters WHM, Steegers EAP (1988) Plasma glutathione Stransferase alpha 1-1 : a more sensitive marker for hepatocellular damage than serum alanine aminotransferase in hypertensive disorders of pregnancy. Am J Obstet Gynecol 178: 161-5
13. Knapen MFCM, van Altena AM, Peters WHM et al (1998) Liver function following pregnancy complicated by the HELLP syndrome. Br J Obstet Gynaecol 105: 1208-10
14. Lopez-Llera M, Espinosa M, De Leon MD, Linares UR (1976) Abnormal coagulation and fibrinolysis in eclampsia, A clinical and correlation study. Am J Obstet Gynecol 124: 680
15. Lorentzen B, Endersen MJ, Clausen T Henriksen T (1994) Fasting serum free fatty acid and triglycerides are increased before 20weeks of gestation in women who later develop pre-eclampsia. Hypertens Pregnancy 13: 103-9
16. Magann EF, Bass D, Chauhan SP, Sullivan DL, Martin RW, Martin JN (1994) Antepartum corticosteroids: disease stabilization in patients with the syndrome of hemolysis, elevated liver enzymes and low platelets (HELLP). Am J Obstet Gynecol 111: 1148-53
17. Martin JN, Blake PG, Lowry SL, Perry KG, Files JC, Morrison JC (1990) Pregnancy complicated by preeclampsia - eclampsia with the syndrome of hemolysis, elevated liver enzymes, and low platelet count: how rapid is postpartum recovery? Obstet Gynecol 76: 737-41
18. Martin JN, Blake PJ, Perry KG. McCaul JF, Hess LW, Martin RW (1991) The natural history of HELLP syndrome: patterns of disease progression and regression. Am J Obstet Gynecol 164: 1500-13
19. Martin JN. Perry KG, Blake PG, May WA, Moore A, Robinette L (1997) Better maternal outcomes are achieved with dexamethasone therapy for postpartum HELLP (hemolysis, elevated liver enzymes, and thrombocytopenia) syndrome. Am J Obstet Gvnecol 177: 1011-17
20. McKenna J, Dover NL, Brame RG (1983) Preeclampsia associated with the syndrome of haemolysis, elevated liver enzymes and low platelets in severe preeclampsia-eclampsia. Obstet Gynecol 62: 751
21. Minakami H, Oka N, Sato T, Tamada T, Yasuda Y, Hirota N (1988) Pre-eclampsia: a microvesicular fat disease of the liver? ,4m J Obstet Gynecol 159: 1043-7
22. Moodley J, Pillay M (1985) The HELLP syndrome in severe hypertensive crisis of pregnancy: does it exist? S Afr Med J 67: 246
23. O'Sullivan AJ, Huffman DM, Ho KKY (1995) Estrogen, lipid oxidation and body fat. N Engl J Med 333: 669-70
24. Peristeris R Clark BD, Gatti S et al (1992) N-acetylcysteine and glutathione as inhibitors of tumour necrosis factor production. Cell Immunol 140: 390-9
25. Reubinoff BE, Schenker JG (1991) HELLP syndrome - a syndrome of hemolysis, elevated liver enzymes and low platelet count -complicating preeclampsia-eclampsia. IntJ Gynecol Obstet 36: 95-102
26. Roberts JM, Redman CWG (1993) Pre-eclampsia: more than pregnancy-induced hypertension. Lancet 341: 1447-51
27. Sattar N, Bendomir A, Berry C, Shepherd J, Greer IA, Packard CJ ( 1997) Lipoprotein subfraction concentrations in preeclampsia: pathogenic parallels to atherosclerosis. Obstet Gynecol 89: 403-8
28. Schwartz ML, Brenner WE (1983) Pregnancy-induced hypertension with life-threatening thrombocytopaenia. Am J Obstet Gynecol 146: 756-9
29. Sibai SM (1990) The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much ado about nothing? Am J Obstet Gynecol 162: 311-16
30. Sibai BM, Taslimi MM, El Nazer A et al (1986) Maternalperinatal outcome associated with the syndrome of hemolysis, elevated liver enzymes and low platelets in severe preeclampsia-eclampsia. Am J Obstet Gynecol 155: 501-9
31. Sibai BM, Ramadan MK, Usta I, Salama M, Mercer BM, Friedman SA (1993) Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am J Obstet Gynecol 169: 1000-6
32. Sullivan CA, Magann EF, Perry KG, Roberts EW, Blake PG, Martin JN (1994) The recurrence risk of the syndrome of haemolysis, elevated liver enzymes and low platelets (HELLP) in subsequent gestations. Am J Obstet Gynecol 171:940-3
33. Thiagarajah S, Bourgeouis FJ, Harbert GM, Caudle MR (1984) Thrombocytopenia in preeclampsia: associated abnormalities and management principles. Am J Obstet Gynecol 150: 1-7
34. Tomsen T (1995) HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) presenting as generalized malaise. Am J Obstet Gynecol 172: 1876-80
35. Torbergsen T, Øian P, Mathiesen E, Borud O (1989) Preeclampsia - a mitochondria! disease? Acta Obstet Gvnecol Scand 68: 145-8
36. Tyni T, Ekholm E, Pihko H (1998) Pregnancy complications are frequent in long chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency. Am J Obstet Gynecol 178: 603-8
37. Wang Y, Walsh SW, Guo J, Zhang J (1991) The imbalance between thromboxane and prostacyclin in pre-eclampsia is associated with an imbalance between lipid peroxidases and vitamin E in maternal blood. Am J Obstet Gynecol 165:1695-700
38. Weinstein L (1982) Syndrome of haemolysis, elevated liver enzymes and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 142: 159-67