Structural heterogeneity of the binding sites of HSA for phenyl-groups and medium-chain fatty acids: Demonstration of equilibrium between different binding conformations

European Journal of Biochemistry

Volumn 260, Issue 2, 1999, Pages 470-476

  Lund, Martin ^a   Bjerrum, Ole J ^b   Bjerrum, Morten J ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NOVO NORDISK A S   (Denmark)

Author keywords

Albumin; Binding, protein conformation; Hydrophobic interaction chromatography; Phenyl sepharose; Structural heterogeneity

Indexed keywords

HUMAN SERUM ALBUMIN; MEDIUM CHAIN FATTY ACID; SEPHAROSE;

ARTICLE; BINDING SITE; CHROMATOGRAPHY; HUMAN; IONIC STRENGTH; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE;

BINDING SITES; CIRCULAR DICHROISM; DECANOIC ACIDS; FATTY ACIDS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; OSMOLAR CONCENTRATION; PROTEIN BINDING; PROTEIN CONFORMATION; SEPHAROSE; SERUM ALBUMIN;

EID: 0033106407     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00175.x     Document Type: Article

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