Synthesis of α-aminoacyl derivatives of melphalan for use in antibody directed enzyme pro-drug therapy

Tetrahedron

Volumn 55, Issue 11, 1999, Pages 3265-3276

  Larden, Dale W ^a   Andrew Cheung, H T ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE; ANTIBODY; MELPHALAN; PRODRUG;

ARTICLE; CHEMICAL REACTION; CHLORINATION; DRUG STRUCTURE; DRUG SYNTHESIS; METHODOLOGY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0033106175     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(98)01139-9     Document Type: Article

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32. 22 131-132°C).
33. 22 + 15.9° (c 2, dioxane)).
34. If HCl was in excess, esterification during crystallization with 2-propanol occurred.