Efficient discrimination between different densities of target antigen by tetracycline-regulatable T bodies

Human Gene Therapy

Volumn 10, Issue 4, 1999, Pages 559-563

  Alvarez Vallina, Luis ^a,b   Russell, Stephen J ^a,c  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ANTIGEN; T LYMPHOCYTE RECEPTOR; TETRACYCLINE;

APOPTOSIS; ARTICLE; CELL SURFACE; GENE THERAPY; HUMAN; HUMAN CELL; RECEPTOR AFFINITY; RECEPTOR DENSITY; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIGENS, NEOPLASM; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-2; JURKAT CELLS; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TETRACYCLINE;

EID: 0033104970     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950018634     Document Type: Article

References (17)

1. ALTENSCHMIDT, U., KLUNDT, E., and GRONER, B. (1997). Adoptive transfer of in vitro-targeted, activated T lymphocytes results in total tumor regression. J. Immunol. 159, 5509-5515.
2. ALVAREZ-VALLINA, L., and HAWKINS, R.E. (1996). Antigen-specific targeting of CD28 mediated T-cell co-stimulation using chimeric single-chain antibody variable fragment-CD28 receptors. Eur. J. Immunol. 26, 2304-2309.
3. ALVAREZ-VALLINA, L., AGHA-MOHAMMADI, S., HAWKINS, R.E., and RUSSELL, S.J. (1997). Pharmacological control of antigen responsiveness in genetically modified T lymphocytes. J. Immunol. 159, 5889-5895.
4. BOEHME, S.A., and LENARDO, M.J. (1993). Ligand-induced apoptosis of mature T lymphocytes (propriocidal regulation) occurs at distinct stages of the cell cycle. Leukemia (Baltimore) 7, 845-849.
5. BROCKER, T., and KARJALAINEN, K. (1995). Signals through T cell receptor-ζ chain alone are insufficient to prime resting T-lymphocytes. J. Exp. Med. 181, 1653-1659.
6. BROCKER, T., RIEDINGER, M., and KARJALAINEN, K. (1996). Redirecting the complete T cell receptor/CD3 signaling machinery towards native antigens via modified T cell receptor. Eur. J. Immunol. 26, 1770-1774.
7. CRITCHFIELD, J.M., RACKE, M.K., ZUÑIGA-PFLÜCKER, J.C., CANNELLA, B., RAINE, C.S., GOVERMAN, J., and LENARDO, M.J. (1994). T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis. Science 263, 1139-1143.
8. ESHHAR, Z., WAKS, T., GROSS, G., and SCHINDLER, D.G. (1993). Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the γ or ζ subunits of the immunoglobulins and T-cell receptors. Proc. Natl. Acad. Sci. U.S.A. 90, 720-724.
9. GOSSEN, M., and BUDJARD, H. (1992). Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U.S.A. 89, 5547-5551.
10. HAWKINS, R.E., RUSSELL, S.J., and WINTER, G. (1992). Selection of phage antibodies by binding affinity. Mimicking affinity maturation. J. Mol. Biol. 226, 889-896.
11. LENARDO, M.J. (1991). Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature (London) 353, 858-861.
12. LYNCH, D.H., RAMSDELL, F., and ALDERSON, M.R. (1995). Fas and FasL in the homeostatic regulation of immune responses. Immunol. Today 16, 569-574.
13. PARDOLL, D. (1994). Cancer. Curr. Opin. Immunol. 6, 705.
14. SHINKAI, Y., MA, A., CHENG, H.-L., and ALT, F.W. (1995). CD3∈ and CD3ζ cytoplasmic domains can independently generate signals for T cell development and function. Immunity 2, 401-411.
15. VALITUTTI, S., MÜLLER, S., CELLA, M., PADOVAN, E., and LANZAVECCHIA, A. (1995). Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature (London) 375, 148-151.
16. VERMES, Y., HAANEN, C., and REWTELINGSPERGER, C.P.M. (1995). A novel assay for apoptosis: Flow cytometric detection of phophatidylserine expression of early apoptotic cells using fluorescein labeled annexin V. J. Immunol. Methods 180, 39-52.
17. VIOLA, A., and LANZAVECCHIA, A. (1996). T cell activation determined by T cell receptor number and tunable thresholds. Science 273, 104-106.