Immunohistochemical and neurochemical studies on nigral and striatal functions in the circling (ci) rat, a genetic animal model with spontaneous rotational behavior

Neuroscience

Volumn 89, Issue 2, 1999, Pages 461-471

  Richter, A ^a   Ebert, U ^a   Nobrega, J N ^b   Vallbacka, J J ^b   Fedrowitz, M ^a   Loscher W ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Brain asymmetry; Dopamine; Movement disorders; Parkinsonism

Indexed keywords

TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BREEDING; DOPAMINE BRAIN LEVEL; IMAGE ANALYSIS; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; MOTOR DYSFUNCTION; NEUROCHEMISTRY; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS;

ANIMALS; BEHAVIOR, ANIMAL; BIOGENIC MONOAMINES; BRAIN; CARRIER PROTEINS; CORPUS STRIATUM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MUTATION; NERVE TISSUE PROTEINS; RATS; RATS, INBRED LEW; RECEPTORS, DOPAMINE; ROTATION; STEREOTYPIC MOVEMENT DISORDER; SUBSTANTIA NIGRA; TEGMENTUM MESENCEPHALI; TYROSINE 3-MONOOXYGENASE;

EID: 0033103933     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00321-2     Document Type: Article

References (39)

1. 1. Ali S. F., Newport G. D. and Bracha H. S. (1994) Phencyclidine and (+)MK-801-induced circling preference - correlation with monoamine levels in striatum of the rat brain. Neurotoxicol. Teratol. 16, 335-342.
2. 2 receptors. Nature 377, 424-428.
3. 3. Bracha H. S. and Gilger J. W. (1996) Measuring spontaneous turning behaviors in children and adults. In Motor Activity and Movement Disorders. Research Issues and Applications (eds Sanberg P. R. et al.), pp. 323-341. Humana, Totowa.
4. 4. Campbell J. M., Payne A. P., Gilmore D. P., Byrne J. E., Russell D., McGadey J., Clarke D. J., Davies R. W. and Sutcliffe R. G. (1996) Neostriatal dopamine depletion and locomotor abnormalities due to the Albino Swiss rat agu mutation. Neurosci. Lett. 213, 173-176.
5. 5. Carey R. J. (1986) Relationship of changes in spontaneous motor activity to spontaneous circling in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra. Expl Neurol. 92, 591-600.
6. 6. Carlson J. N. and Glick S. D. (1996) Circling behavior in rodents. Methodology, biology, and functional implications. In Motor Activity and Movement Disorders. Research Issues and Applications (eds Sanberg P. R. et al.), pp. 269-300. Humana, Totowa.
7. 7. Clarke D. J. and Payne A. P. (1994) Neuroanatomical characterization of a new mutant rat with dopamine depletion in the substantia nigra. Eur. J. Neurosci. 6, 885-888.
8. 8. Coggeshall R. E. and Lekan H. A. (1996) Methods for determining numbers of cells and synapses: a case for more uniform standards of review. J. comp. Neurol. 364, 6-15.
9. 9. Davies R. W., Sutcliffe R. G., Shiels P., Duran Alonso M., Clarke D. J., Gilmore D. and Payne A. P. (1995) Characterization of a rat mutant with similarities to Parkinson's disease. Soc. Neurosci. Abstr. 21, 1244.
10. 1A dopamine receptors. Proc. natn. Acad. Sci. U.S.A. 91, 12,564-12,568.
11. 10a. Ebert U. and Löscher W. (1995) Strong induction of c-fos in the piriform cortex during focal seizures evoked from different limbic brain sites. Brain Res. 671, 338-344.
12. 2 receptor in the chakragati mouse: neurobehavioral dysfunction in a transgenic insertional mutant. Brain Res. 580, 18-26.
13. 12. Fitzgerald L. W., Ratty A. K., Teitler M., Gross K. W. and Glick S. D. (1993) Specificity of behavioral and neurochemical dysfunction in the chakragati mouse: A novel genetic model of a movement disorder. Brain Res. 608, 247-258.
14. 13. Fornaguera J., Carey R., Huston J. and Schwarting R. (1995) Behavioral asymmetries and recovery related with different degrees of unilateral striatal dopamine depletion. Soc. Neurosci. Abstr. 20, 175.
15. 14. Glick S. D., Jerussi T. P. and Fleisher L. N. (1976) Turning in circles: the neuropharmacology of rotation. Life Sci. 18, 889-896.
16. 15. Gupta M., Felten D. L. and Ghetti B. (1987) Selective loss of monoaminergic neurons in weaver mutant mice - an immunocytochemical study. Brain Res. 402, 379-382.
17. 16. Jaber M., Robinson S. W., Missale C. and Caron M. G. (1996) Dopamine receptors and brain function. Neuropharmacology 35, 1503-1519.
18. 17. Jellinger K. (1987) The pathology of parkinsonism. In Movement Disorders 2 (eds Marsden C. D. et al.), pp. 124-165. Butterworths, London.
19. 18. Kaakkola S. and Teravainen H. (1990) Animal models of parkinsonism. Pharmac. Toxicol. 67, 95-100.
20. 19. Löscher W., Annies R. and Hönack D. (1991) The N-methyl-D-aspartate receptor antagonist MK-801 induces increases in dopamine and serotonin metabolism in several brain regions of rats. Neurosci. Lett. 128, 191-194.
21. 20. Löscher W., Annies R. and Richter A. (1994) Marked regional disturbances in brain metabolism of monoaminergic neurotransmitters in the genetically dystonic hamster. Brain Res. 658, 199-208.
22. 21. Löscher W., Richter A., Nikkhah G., Rosenthal C., Ebert U. and Hedrich H.-J. (1996) Behavioural and neurochemical dysfunction in the circling (ci) rat: a novel genetic animal model of a movement disorder. Neuroscience 74, 1135-1142.
23. 22. Löscher W., Vetter M., Müller F., Böhme G. and Stoltenburg-Didinger G. (1984) Development of a synaptosomal model to determine drug-induced in vivo changes in GABA-levels of nerve endings in 11 brain regions of the rat. Neurochem. Int. 6, 441-451.
24. 3H]2β-carbomethoxy-3β-(4-fluorophenyl)tropane. Molec. Pharmac. 36, 518-534.
25. 24. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates. 2nd Edn. Academic, Sydney.
26. 25. Pycock C. J. (1980) Turning behaviour in animals. Neuroscience 5, 461-514.
27. 26. Ratty A. K., Fitzgerald L. W., Titeler M., Glick S. D., Mullins J. J. and Gross K. W. (1990) Circling behavior exhibited by a transgenic insertional mutant. Molec. Brain Res. 8, 355-358.
28. 27. Ratty A. K., Gross K. W., Fitzgerald L. W. and Glick S. D. (1994) The chakragati mouse: a model for brain dopaminergic dysfunction. In Dopamine Receptors and Transporters (ed. Niznik H. B.), pp. 493-510. Marcel Dekker, New York.
29. 28. Roffler-Tarlov S. and Graybiel A. M. (1984) Weaver mutation has differential effects on the dopamine-containing innervation of the limbic and nonlimbic striatum. Nature 307, 62-66.
30. 29. Schmidt M., Sawyer B. D., Perry K. W., Fuller R. W., Foreman M. M. and Ghetti B. (1982) Dopamine deficiency in the weaver mutant mouse. J. Neurosci. 2, 376-380.
31. 30. Scott D. L., Campbell J. M., McGadey J., Clarke D. J., Gilmore D. P. and Payne A. P. (1994) Noradrenergic deficits in the locus coeruleus of AS/AGU rats. Eur. J. Neurosci. 7 Suppl., 96.
32. 31. Shima F. (1984) Circling behavior depending on striopallidal and vestibular functions. In Advances in Neurology (eds Hassler R. G. et al.), Vol. 40, pp. 47-54. Raven, New York.
33. 32. Simon J. R. and Ghetti B. ( 1994) The weaver mutant mouse as a model of nigrostriatal dysfunction. Molec. Neurobiol. 9, 183-189.
34. 33. Strange P. G. (1993) Dopamine receptors. In Neurotransmitter Receptors (ed. Hucho F.), pp. 251-265. Elsevier, Amsterdam.
35. 34. Triarhou L. C. and Ghetti B. (1987) Neuroanatomical substrate of behavioral impairment in weaver mutant mice. Expl Brain Res. 68, 434-436.
36. 35. Uhl G. R. and Kitayama S. (1993) A cloned dopamine transporter. Potential insights into Parkinson's disease pathogenesis. Adv. Neurol. 60, 321-324.
37. 36. Ungerstedt U. (1968) 6-Hydroxydopamine induced degeneration of central monoamine neurons. Eur. J. Pharmac. 5, 107-110.
38. 37. Ungerstedt U. and Arbuthnott G. (1970) Quantitative recording of rotational behavior in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Res. 24, 485-493.
39. 1 receptor mutant mice. Cell 16, 945-955.