The significance of amino acid residue Asp446 for enzymatic stability of rat UDP-glucuronosyltransferase UGT1A6

Archives of Biochemistry and Biophysics

Volumn 363, Issue 1, 1999, Pages 116-120

  Iwano, Hidetomo ^b   Yokota, Hiroshi ^b   Ohgiya, Satoru ^a   Yuasa, Akira ^b  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b RAKUNO GAKUEN UNIVERSITY   (Japan)

Author keywords

Active site; Aspartic acid; Conformation; Heat inactivation; Mutant; Stability; UDP glucuronic acid; UDP glucuronosyltransferase; UGT1A6

Indexed keywords

GLUCURONOSYLTRANSFERASE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME STABILITY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY;

EID: 0033102535     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1998.1065     Document Type: Article

References (24)

1. Dutton, G. J. (1980) in Glucuronidation of Drugs and Other Compounds (Dutton, G. J., Ed.), pp. 69-78, CRC Press, Boca Raton, FL.
2. Burchell, B., and Coughtrie, M. W. H. (1989) Pharmacol. Ther. 43, 261-289.
3. Mackenzie, P. I. (1990) J. Biol. Chem. 265, 3432-3435.
4. Meech, R., and Mackenzie, P. I. (1997) Clin. Exp. Pharmacol. Physiol. 24, 907-915.
5. Ritter, J. K., Chen, F., Sheen, Y. Y., Tran, H. M., Kimura, S., Yeatman, M. T., and Owens, I. S. (1992) J. Biol. Chem. 267, 3257-3261.
6. Emi, Y., Ikushiro, S., and Iyanagi, T. (1995) J. Biochem. (Tokyo) 117, 392-399.
7. Mackenzie, P. I., Owens, I. S., Burchell, B., Bock, K. W., Barioch, A., Belanger, A., Fournel-Gigleux, S., Green, M., Hum, D. W., Iyanagi, T., Lancet, D., Louisot, P., Magdalou, J., Chowdhury, J. R., Ritter, J. K., Schachter, H., Tephly, T. R., Tipton, K. F., and Nebert, D. W. (1997) Pharmacogenetics 7, 255-269.
8. Ciotti, M., Yeatman, M., Sokol, R. J., and Owens, I. S. (1995) J. Biol. Chem. 270, 3284-3291.
9. Pillot, T., Ouzzine, M., Fournel-Gigleux, S., Lafaurie, C., Tebbi, D., Treat, S., Radominska, A., Lester, R., Siest, G., and Magdalou, J. (1993) Biochem. Biophys. Res. Commun. 197, 785-791.
10. Iwano, H., Yokota, H., Ohgiya, S., Yotumoto, N., and Yuasa, A. (1997) Biochem. J. 325, 587-591.
11. Landt, O., Glunet, H. P., and Hahn, U. (1990) Gene 96, 125-128.
12. Ito, H., Fukuda, Y., Murata, K., and Kimura, A. (1983) J. Bacteriol. 153, 163-168.
13. Oeda, K., Sakaki, T., and Ohkawa, H. (1985) DNA 4, 203-210.
14. Yokota, H., Yuasa, A., and Sato, R. (1988) J. Biochem. 104, 531-536.
15. How, J. G., and Hershey, J. W. B. (1981) J. Biol. Chem. 256, 12836-12839.
16. Yokota, H., Ohgiya, N., Ishihara, G., Ohta, K., and Yuasa, (1989) J. Biochem. 106, 248-252.
17. Mackenzie, P. I., and Hanninen, O. (1980) Anal. Biochem. 109, 362-368.
18. Yuasa, A. (1977) J. Coll. Dair. (Ebetu, Jpn.) 7(Suppl.), 103-156.
19. Mackenzie, P. I., and Owens, I. S. (1983) Biochem. Pharmacol. 32, 3777-3781.
20. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275.
21. Bock, K. W., Josting, D., Lilienblum, W., and Pfeil, H. (1979) Eur. J. Biochem. 98, 19-26.
22. Yokota, H., Ando, F., Iwano, H., and Yuasa, A. (1998) Life Sci. 63, 1693-1699.
23. Yokota, H., and Yuasa, A. (1992) J. Biochem. 112, 309-313.
24. Chou, P. Y., and Fasman, G. D. (1978) Adv. Enzymol. 47, 45-148.