Autoreactive T lymphocytes in multiple sclerosis : Pathogenic role and therapeutic targeting

Acta Neurologica Belgica

Volumn 99, Issue 1, 1999, Pages 65-69

  Stinissen, P ^a   Raus, J ^a  

^a HASSELT UNIVERSITY   (Belgium)

Author keywords

Autoimmunity; Autoreactive T cells; Immunotherapy; Multiple sclerosis; Myelin basic protein

Indexed keywords

ALLERGIC ENCEPHALOMYELITIS; AUTOIMMUNITY; HUMAN; IMMUNOLOGY; IMMUNOTHERAPY; MULTIPLE SCLEROSIS; MYELIN SHEATH; REVIEW; T LYMPHOCYTE; VACCINATION;

AUTOIMMUNITY; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; IMMUNOTHERAPY; MULTIPLE SCLEROSIS; MYELIN SHEATH; T-LYMPHOCYTES; VACCINATION;

EID: 0033090608     PISSN: 03009009     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. ALLEGRETTA M., NICKLAS J. A., SRIRAM S., ALBERTINI R. J. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science, 1990, 247 : 718-721.
2. BEN-NUN A., WEKERLE H., COHEN I. R. The rapid isolation of clonable antigen specific T lymphocyte lines capable of mediating autoimmume encephalomyelitis. Eur. J. Immunol., 1981a, 11 : 195-199.
3. BEN-NUN A., WEKERLE H., COHEN I. R. Vaccination against autoimmune encephalomyelitis with T lymphocyte line cells reactive against myelin basic protein. Nature, 1981b, 292 : 60-61.
4. BERNARD C. C. A., JOHNS T. G., SLAVIN A. et al. Myelin oligodendrocyte glycoprotein : a novel candidate autoantigen in multiple sclerosis. J. Mol. Med., 1997, 75 : 77-88.
5. CHOU Y. K., BOURDETTE D. N., OFFNER H. et al. Frequency of T cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis. J. Neuroimmunol., 1992, 38 : 105-113.
6. GENAIN C. P., HAUSER S. L. Creation of a model for multiple sclerosis in Callithrix jacchus marmosets. J. Mol. Med., 1997, 75 : 187-197.
7. HAFLER D. A., SAADEH M. G., KUCHROO V. K., MILFORD E., STEINMAN L. TCR usage in human and experimental demyelinating disease. Immunol. Today, 1996, 17 : 152-159.
8. HERMANS G., STINISSEN P., HAUBEN L. et al. Cytokine profile of myelin basic protein reactive T cells in multiple sclerosis and healthy individuals. Ann. Neurol., 1997, 42 : 18-27.
9. HERMANS G., DE RYCK. L., RAUS J., STINISSEN P. Cytokine Profile of Autoreactive T lymphocytes in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Curr. Trends Immunol., 1998, 1 : 69-78.
10. KUCHROO V. K., MARTIN C. A., GREER J. A. et al. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J. Immunol., 1993, 151 : 4371-82.
11. MARTIN R., MCFARLAND H. F. Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis. Crit. Rev. Clin. Lab. Sc., 1995, 32: 121-182.
12. MEDAER R., STINISSEN P., TRUYEN L., RAUS J., ZHANG J. Depletion of myelin-basic protein autoreactive T cells by T cell vaccination : pilot trial in multiple sclerosis. Lancet, 1995, 346 : 807-808.
13. RIVERS T. M., SCHEWENTKER F. F. Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys. J. Exp. Med., 1935, 61 : 689-702.
14. STEINMAN L. Multiple sclerosis : A coordinated immunological attack against myelin in the central nervous system. Cell, 1996, 85 : 299-302.
15. STINISSEN P., ZHANG J., MEDAER R., VANDEVYVER C., RAUS J. Vaccination with autoreactive T cell clones in multiple sclerosis : Overview of immunological and clinical data. J. Neurosc. Res., 1996, 45 : 500-511.
16. STINISSEN P., RAUS J., ZHANG J. Autoimmune pathogenesis of Multiple Sclerosis : Role of autoreactive T lymphocytes and new immunotherapeutic strategies. Crit. Rev. Immunol., 1997, 17 : 33-75.
17. STINISSEN P., MEDAER R., and RAUS J. Myelin reactive T cells in the autoimmune pathogenesis of multiple sclerosis. Mult. Scler., 1998a, 4 : 203-211.
18. STINISSEN P., ZHANG J., VANDEVYVER C., HERMANS G., RAUS J. γδ T Cell Responses to Activated T cells in Multiple Sclerosis Patients Induced by T Cell Vaccination. J. Neuroimmunol., 1998b, 87 : 94-104.
19. STINISSEN P., MEDEAR R., RAUS J. Preliminary data of an extended open label phase I study of T cell vaccination in Multiple Sclerosis. J. Neuroimmunol., 1998c, 90 : 99 (565).
20. SCHLUESSENER H. J., WEKERLE H. Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of MBP : In vitro selection from unprimed rat T lymphocyte population. J. Immunol., 1985, 135 : 3128-3133.
21. TUOHY V. K. Peptide determinants of myelin proteolipid protein (PLP) in autoimmune demyelinating disease : A review. Neurochem. Res., 1994, 19 : 935-944.
22. VANDEVYVER C., MERTENS N., VAN DEN ELSEN P. et al. Clonal expansion of myelin basic protein-reactive T cells in patients with multiple sclerosis : restricted T cell receptor V gene rearrangements and CDR3 sequence. Eur. J. Immunol., 1995, 25 : 958-968.
23. WUCHERPFENNIG K. W., STROMINGER J. L. Molecular mimicry in T cell mediated autoimmunity : viral peptides activate human T cell clones specific for myelin basic protein. Cell, 1995, 80 : 695-705.
24. ZAMVIL S. S., STEINMAN L. The T lymphocyte in experimental allergic encephalomyelitis. Ann. Rev. Immunol., 1990, 8 : 579-621.
25. ZHANG J., MEDAER R., CHIN Y., HASHIM G. A. et al. Myelin basic protein specific T lymphocytes : precursor frequency, fine specificity and cytotoxicity. Ann. Neurol., 1992, 32 : 330-338.
26. ZHANG J., MEDAER R., STINISSEN P., HAFLER D. A., RAUS J. MHC restricted clonotypic depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science, 1993, 261 :1451-1454.
27. ZHANG J., MARKOVIC S., LACET B., RAUS J. et al. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J. Exp. Med., 1994, 179 : 973-984.
28. ZHANG J., VANDEVYVER C., STINISSEN P. et al. Activation and clonal expansion of human myelin basic protein reactive T cells by bacterial superantigens. J. Autoimmun., 1995a, 8 : 615-632.
29. ZHANG J., VANDEVYVER C., STINISSEN P., RAUS J. In vivo clonotypic regulation of human myelin basic protein reactive T cells by T cell vaccination. J. Immunol., 1995b, 155 : 5868-5877.