Expression of cripto and amphiregulin in colon mucosa from high risk colon cancer families

International Journal of Oncology

Volumn 14, Issue 3, 1999, Pages 437-440

  De Angelis, Ernesto ^a   Grassi, Michele ^a   Gullick, William J ^b   Johnson, Gibbes R ^c   Rossi, Giovanni B ^a   Tempesta, Alfonso ^a   De Angelis, Francesca ^a   De Luca, Antonella ^a   Salomon, David S ^d   Normanno, Nicola ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Amphiregulin; Colon carcinoma; Cripto

Indexed keywords

AMPHIREGULIN; EPIDERMAL GROWTH FACTOR; GLYCOPROTEIN; GROWTH PROMOTOR; KI 67 ANTIGEN; MEMBRANE PROTEIN; SIGNAL PEPTIDE; TDGF1 PROTEIN, HUMAN; TUMOR MARKER; TUMOR PROTEIN;

ADENOMA; ARTICLE; BIOSYNTHESIS; COLON TUMOR; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE MUCOSA; METABOLISM; PATHOLOGY; RISK FACTOR;

ADENOMA; COLONIC NEOPLASMS; EPIDERMAL GROWTH FACTOR; GLYCOPROTEINS; GROWTH SUBSTANCES; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTESTINAL MUCOSA; KI-67 ANTIGEN; MEMBRANE GLYCOPROTEINS; NEOPLASM PROTEINS; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0033088528     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.14.3.437     Document Type: Article

References (16)

1. Salomon DS, Brandt R, Ciardiello F and Normanno N: Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19: 183-232, 1995.
2. Kannan S, De Santis M, Lohmeyer M, Riese DJ, Smith GH, Hynes NE, Seno M, Brandt R, Bianco C, Persico MG, Kenney N, Normanno N, Martinez-Lacaci I, Ciardiello F, Stern DF, Gullick WJ and Salomon DS: Cripto enhances the tyrosine phosphorylation of she and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. J Biol Chem 272: 3330-3335, 1997.
3. Ciardiello F, Tortora G, Bianco C, Selvam MP, Basolo F, Fontanini G, Pacifico F, Normanno N, Brandt R, Persico MG, Salomon DS and Bianco AR: Inhibition of CRIPTO expression and tumorigenicity in human colon cancer cells by antisense RNA and oligodeoxynucleotidcs. Oncogene 9: 291-298, 1994.
4. Normanno N, Selvam MP, Bianco C, Damiano V, De Angelis E, Grassi M, Magliulo G, Tortora G, Salomon DS and Ciardiello F: Amphiregulin anti-sense oligodeoxynucleotides inhibit growth and transformation of a human colon carcinoma cell line. Int J Cancer 62: 762-766, 1995.
5. Normanno N, Bianco C, Damiano V, De Angelis E, Selvam MP, Grassi M, Magliulo G, Tortora G, Bianco AR, Mendelsohn J, Salomon DS and Ciardiello F: Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides. Clin Cancer Res 2: 601-609, 1996.
6. Ciardiello F, Kim N, Saeki T, Dono R, Persico MG, Plowman GD, Garrigues J, Radke S, Todaro GJ and Salomon DS: Differential expression of epidermal growth factor-related proteins in human colorectal tumors. Proc Natl Acad Sci USA 88: 7792-7796, 1991.
7. Saeki T, Chen-Feng Q, Johnson GR, Gullick W, Tahara E, Normanno N, Ciardiello F, Kenney N, Stromberg K and Salomon DS: Differential immunohistochemical localization of amphiregulin and cripto in human normal colon and colorectal tumors. Cancer Res 52: 3467-3473, 1992.
8. Saeki T, Salomon DS, Johnson GR, Gullick WJ, Mandai K, Yamagami K, Moriwaki S, Tanada M, Takashima S and Tahara E: Association of epidermal growth factor-related peptides and type I receptor tyrosine kinase receptors with prognosis of human colorectal carcinomas. Jpn J Clin Oncol 25: 240-249, 1995.
9. Gagliardi G, Talbot IC, Northover JMA, Warren A, Stamp GWH, Lalani E, Gullick WJ and Pignatelli M: Immunolocalisation of cripto and amphiregulin in rectal cancer: correlation with prognosis. Int J Oncol 4: 865-871, 1994.
10. Lynch HT, Smyrk T and Lynch J: An update of HNPCC. Cancer Genet Cytogenet 93: 84-99, 1997.
11. Deschner EE: Early proliferative changes in gastrointestinal neoplasia. Am J Gastroenterol 77: 207-211, 1982.
12. Lynch PM, Wargovich MJ, Lynch HT, Palmer C, Lanspa S, Drohuard T and Lynch J: A follow-up study of colonic epithelial proliferation as a biomarker in a native-American family with hereditary nonpolyposis colon cancer. J Natl Cancer Inst 83: 951-954, 1991.
13. Cats A, De Vries EGE and Kleibeuker JH: Proliferation rate in hereditary nonpolyposis colon cancer. J Natl Cancer Inst 83: 1687-1688, 1991.
14. Rooney PS, Robinson MHE, Clarke PA, Hardcastle JD and Armitage NC: Individuals with a strong family history of colorectal cancer demonstrate abnormal rectal mucosal proliferation. Br J Cancer 80: 249-251, 1993.
15. Patchett SE, Alstead EM, Saunders BP, Hodgson SV and Farthing MJG: Regional proliferative patterns in the colon of patients at risk for hereditary nonpolyposis colorectal cancer. Dis Colon Rectum 40: 168-171, 1997.
16. Saeki T, Salomon DS, Normanno N, Johnson GR, Gullick WJ, Mandai K, Moriwaki S, Tahashima S, Kuniyasu M, Tahara E, Kawami H, Nishiyama M and Toge T: Immunohistochemical detection of cripto-1, amphiregulin and transforming growth factor alpha in human gastric carcinomas and intestinal metaplasias. Int J Oncol 5: 215-223, 1994.