Inhibition of the Insulin Receptor Kinase Phosphorylation by Nitric Oxide: Functional and Structural Aspects

Antioxidants and Redox Signaling

Volumn 1, Issue 1, 1999, Pages 45-53

  Schmid, Elmar ^a   Hotz Wagenblatt, Agnes ^a   Dröge, Wulf ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIETHYL 2 HYDROXY 2 NITROSOHYDRAZINE; 1,1-DIETHYL-2-HYDROXY-2-NITROSOHYDRAZINE; BUTHIONINE SULFOXIMINE; DRUG DERIVATIVE; GLUTATHIONE; HYDRAZINE DERIVATIVE; INSULIN; INSULIN RECEPTOR; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROGEN OXIDE; PENICILLAMINE;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CULTURE MEDIUM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HAMSTER; HUMAN; METABOLISM; PHOSPHORYLATION; PROTEIN CONFORMATION; SERODIAGNOSIS;

ANIMALS; BUTHIONINE SULFOXIMINE; CHO CELLS; CRICETINAE; CULTURE MEDIA, SERUM-FREE; GLUTATHIONE; HUMANS; HYDRAZINES; INSULIN; MODELS, MOLECULAR; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROGEN OXIDES; PENICILLAMINE; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN CONFORMATION; RECEPTOR, INSULIN; S-NITROSO-N-ACETYLPENICILLAMINE; TRANSFECTION;

EID: 0033086311     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.1999.1.1-45     Document Type: Article

References (25)

1. DECKER, K., GUI, M., and SCHIRMER, R.H. (1995). Inhibition of human glutathione reductase by S-nitrosoglutathione. Eur. J. Biochem. 234, 472-478.
2. BÉDARD, S., MARCOTTE, B., and MARETTE, A. (1997). Cytokines modulate glucose transport in skeletal muscle by inducing the expression of inducible nitric oxide synthase. Biochem J. 325, 487-493.
3. CAHILL, G.F., JR. (1971). The Banting memorial lecture 1971. Physiology of insulin in man. Diabetes 20, 785-799.
4. CARVALHO, C.R., BRENELLI, S.L., SILVA, A.C., NUNES, A.L., VELLOSO, L.A., and SAAD, M.J. (1996). Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscles of rats. Endocrinology 137, 151-159.
5. CASELLI, A., CAMICI, G., MANAO, G., MONETI, G., PAZZAGLI, L., CAPPUGI, G., and RAMPONI, G. (1994). Nitric oxide causes inactivation of the low molecular weight phosphotyrosine protein phosphatase. J. Biol. Chem. 269, 24878-24882.
6. DAMSBO, P., VAAG, A., HOTHER-NIELSEN, O., and BECK-NIELSEN, H. (1991). Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34, 239-245.
7. ECK, H.-P., GMÜNDER, H., HARTMANN, M., PETZOLDT, D., DANIEL, V., and DRÖGE, W. (1989). Low concentrations of acid soluble thiol (cysteine) in the blood plasma of HIV-1 infected patients. Biol. Chem. Hoppe-Seyler 370, 101-108.
8. ESTRADA, C., GÓMEZ, C., MARTIN-NIETO, J., DE FRUTOS, T., and JIMÉNEZ, A. (1997). Nitric oxide reversibly inhibits the epidermal growth factor receptor tyrosine kinase. Biochem. J. 326, 369-376.
9. FREIDENBERG, G.R., HENRY, R.R., KLEIN, H.H., REICHART, D.R., and OLEFSKY, J. (1987). Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects. J. Clin. Invest. 79, 240-250.
10. FUKAGAWA, N.K., MINAKER, K.L., YOUNG, V.R., MATTHEWS, D.E., BIER, D.M., and ROWE, J.W. (1989). Leucine metabolism in aging humans: effect of insulin and substrate availability. Am. J. Physiol. 256, E288-E294.
11. GRIFFITH, O., and MEISTER, A. (1979). Potent and specific inhibitor of glutathione synthesis by buthionine sulfoximine (S-n-butyl-homocysteine sulfoximine). J. Biol. Chem. 254, 7558-7560.
12. HAGLER, A.T., and LIFSON, S. (1974). Energy functions for peptides and proteins. II. The amide hydrogen bond and calculation of amide crystal properties. J. Am. Chem. Soc. 96, 5327-5335.
13. HUBBARD, S.R. (1997). Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J. 16, 5572-5581.
14. HUBBARD, S.R., WIE, L., ELLIS, L., and HENDRICKSON, W.A. (1994). Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature 372, 746-754.
15. LANDER, H.M., SEHAJPAL, P., LEVINE, D.M., and NOVOGRODSKY, A. (1993). Activation of human peripheral blood mononuclear cells by nitric oxide-generating compounds. J. Immunol. 150, 1509-1516.
16. LANDER, H.M., MILBANK, A.J., TAURAS, J.M., HAJJAR, D.P., HEMPSTEAD, B.L., SCHWARTZ, G.D., KRAEMER, R.T., MIRZA, U.A., CHAIT, B.T., BURK, S.C., and QUILLIAM, L.A. (1996). Redox regulation of cell signalling. Nature 381, 380-381.
17. LEE, J., and PILCH, P.F. (1994). The insulin receptor: structure, function, and signaling. Am. J. Physiol. 266, C319-C334.
18. LEI, S.Z., PAN, Z.-H., AGGARWAL, S.K., CHEN, H.-S.V., HARTMAN, J., SUCHER, N.J., and LIPTON, S.A. (1992). Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex. Neuron 8, 1087-1099.
19. MACAULAY, S.L., POLITES, M., FRENKEL, M.J., HEWISH, D.R., and WARD, C.W. (1995). Mutagenic structure/function analysis of the cytoplasmic cysteines of the insulin receptor. Biochem. J. 306, 811-820.
20. MOLINA Y VEDIA, L., MCDONALD, B., REEP, B., BRÜNE, B., DI SILVIO, M., BILLIAR, T.R., and LAPETINA, E.G. (1992). Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J. Biol. Chem. 267, 24929-24932.
21. SCHMID, E., EL BENNA, J., GALTER, D., KLEIN, G., and DRÖGE, W. (1998). Redox priming of the insulin receptor β-chain associated with altered tyrosine kinase activity and insulin responsiveness in the absence of tyrosine autophosphorylation. FASEB J. 12, 863-870.
22. STAMLER, J.S. (1994). Redox signaling: Nitrosylation and related target interactions of nitric oxide. Cell 78, 931-936.
23. STAMLER, J.S., SIMON, D.I., OSBORNE, J.A., MULLINS, M.E., JARAKI, O., MICHEL, T., SINGEL, D.J., and LOSCALZO, J. (1992). S-nitrosylation of proteins with nitric oxide: Synthesis and characterization of biologically active compounds. Proc. Natl. Acad. Sci. USA 89, 444-448.
24. TAKAYAMA, S., KAHN, C.R., KUBO, K., and FOLEY, J.E. (1988). Alterations in insulin receptor autophosphorylation in insulin resistance: Correlation with altered sensitivity to glucose transport and antilipolysis to insulin. J. Clin. Endocrinol. Metab. 66, 992-999.
25. TAYLOR, S.S., RADZIO-ANDZELM, E., and HUNTER, T. (1995). How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase. FASEB J. 9, 1255-1266.