1H NMR investigation of changes in the metabolic profile of synovial fluid in bilateral canine osteoarthritis with unilateral joint denervation

Osteoarthritis and Cartilage

Volumn 7, Issue 2, 1999, Pages 165-172

  Damyanovich, A Z ^a,b   Styaples, J R ^b   Marshall, K W ^b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Bilateral Canine Model; Nuclear Magnetic Resonance Spectroscopy; Osteoarthritis; Synovial fluid

Indexed keywords

ACETIC ACID; CREATINE; CREATININE; GLUTAMIC ACID; GLUTAMINE; GLYCEROL; GLYCOPROTEIN; HYDROXYBUTYRIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; CONTROLLED STUDY; DENERVATION; DOG; KNEE OSTEOARTHRITIS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SYNOVIAL FLUID; ANIMAL; DISEASE MODEL; INNERVATION; KNEE; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALS; DENERVATION; DISEASE MODELS, ANIMAL; DOGS; KNEE JOINT; MAGNETIC RESONANCE SPECTROSCOPY; OSTEOARTHRITIS, KNEE; SYNOVIAL FLUID;

EID: 0033084199     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.1998.0205     Document Type: Article

References (27)

1. 1h NMR studies of human blood plasma- Assignment of resonances for lipoproteins. FEBS Lett 1987;219:239-43.
2. Nicholson JK, O'Flynn MP, Sadler PJ, Macleod AF, Juul SM, Sonksen PH. Proton-nuclear magnetic- Resonance studies of serum, plasma and urine from fasting, normal and diabetic subjects. Biochem J 1984;217:365-75.
3. Nicholson JK, Timbrell JA, Sadler PJ. Proton NMR spectra of urine as indicators of renal damage. Mol Pharmacol 1985;27:644-51.
4. 1h MR spectroscopy. J Orthop Res 1997, in press.
5. Dekel S, Weissman SL. Joint changes after overuse and peak overloading of rabbit knees in vivo. Acta Orthop Scand 1978;49:519-28.
6. Marshall KW. Joint Afferent Modulation of Muscle Responses in The Awake Cat. [dissertation]. Toronto (Canada): Univ. Toronto; 1994.
7. Marshall KW, Tatton WG. Joint receptors modulate short and long latency muscle responses in the awake cat. Exp Br Res 1990;83:137-50.
8. O'Connor BL, Visco DM, Brandt KD, Albrecht M, O'Connor AB. Sensory nerves only temporarily protect the unstable canine knee joint from osteoarthritis. Evidence that sensory nerves reprogram the central nervous system after cruciate ligament transection. Arth Rheum 1993;36:1154-63.
9. O'Connor BL, Visco DM, Brandt KD, Myers SL, Kalasinski LA. Neurogenic acceleration of osteoarthrosis. The effects of previous neurectomy of the articular nerves on the development of osteoarthrosis after transection of the anterior cruciate ligament in dogs. J Bone Joint Surg 1992;74A: 367-76.
10. Radin EL, Ehrlich MG, Chernack R, Abernethy P, Paul IL, Rose RM. Effect of repetitive impulsive loading on the knee joints of rabbits. Clin Orthop Rel Res 1978;131:288-93.
11. Radin EL, Martin RB, Burr DB, Caterson B, Boyd RD, Goodwin C. Effects of mechanical loading on the tissues of the rabbit knee. J Orthop Res 1984;2:221-34.
12. Marshall KW, Chan ADM. Bilateral canine model of osteoarthritis. J Rheumatol 1996;23:344-50.
13. Marshall KW, Chan ADM. Articular cartilage degeneration following joint deafferentation. J Rheumatol 1997, in press.
14. Bell JD, Brown JCC, Nicholson JK, Sadler PJ. Assignment of resonances for 'acute-phase' glyco-proteins in high resolution proton NMR spectra of human blood plasma. FEBS Lett 1987;215:311-5.
15. 1h-nmr spectroscopy of human blood plasma. J Pharm Biomed Anal 1993;11:267-76.
16. Nicholson JK, Wilson ID. High resolution proton magnetic resonance spectroscopy of biological fluids. Prog NMR Spectr 1989;21:449-501.
17. Foxall PJD, Parkinson JA, Sadler IJ, Lindon JC, Nicholson JK. Analysis of biological fluids using 600 mhz proton NMR spectroscopy: Application of homonuclear two dimensional j-resolved spectroscopy to urine and blood plasma for spectral simplification and assignment. J Pharm Biomed Anal 1993;11:21-31.
18. Bjorntorp P. Effect of ketone bodies on lipolysis in adipose tissue in vitro. J Lipid Res 1966;7:621-6.
19. Grootveld M, Henderson DB, Farrell A, Blake DR, Parkes HG, Haycock P. Oxidative damage to hyaluronate and glucose in synovial fluid during exercise of the inflamed rheumatoid joint: Detection of abnormal low-molecular-mass metabolites by proton-nmr spectroscopy. Biochem J 1991;273: 459-67.
20. Naughton DP, Whelan M, Smith EC, Williams R, Blake DR, Grootveld M. An investigation of the abnormal metabolic status of synovial fluid from patients with rheumatoid arthritis by high field proton nuclear magnetic resonance spectroscopy. FEBS Lett 1993;317:135-8.
21. Naughton DP, Haywood R, Blake DR, Edmonds S, Hawkes GE, Grootveld M. A comparative evaluation of the metabolic profiles of normal and inflammatory knee-joint synovial fluids by high resolution proton NMR spectroscopy. FEBS Lett 1993;332:221-5.
22. Uchiyama H, Dobashi Y, Ohkouchi K, Nagasawa K. Chemical change involved in the oxidative reductive depolymerization of hyaluronic acid. J Biol Chem 1990;265:7753-9.
23. Schiller J, Arnhold J, Sonntag K, Arnold K. NMR studies on human, pathologically changed synovial fluids: Role of hypochlorous acid. Magn Reson Med 1996;35:848-53.
24. Schiller J, Arnhold J, Arnold K. NMR studies of the action of hypochlorous acid on native pig articular cartilage. Eur J Biochem 1995;233:672-6.
25. Schiller J, Arnhold J, Grunder W, Arnold K. The action of hypocholorous acid on polymeric components of cartilage. Biol Chem Hoppe-seyler 1994;375:167-72.
26. 1h nuclear magnetic resonance investigation of synovial fluid components in osteoarthritis, rheumatoid arthritis, and traumatic effusions. Br J Rheumatol 1989;28:23-7.
27. Naughton DP, Knappitt J, Fairburn K, Gaffney K, Blake DR, Grootveld M. Detection and investigation of the molecular nature of low-molecular-mass copper ions in isolated rheumatoid knee-joint synovial fluid. FEBS Lett 1995;361:167-72.