Decreased platelet alpha-2 adrenoceptor density in major depression: Effects of tricyclic antidepressants and fluoxetine

Biological Psychiatry

Volumn 45, Issue 3, 1999, Pages 278-284

  Maes, Michael ^a   Van Gastel, An ^a   Delmeire, Laure ^a   Meltzer, Herbert Y ^b  

^a Clinical Research Center for Mental Health of Antwerp   (Belgium)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

Alpha 2 receptor; Catecholamines; Depression; Fluoxetine; Rauwolscine

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; AMITRIPTYLINE; DESIPRAMINE; FLUOXETINE; MIANSERIN; NORADRENALIN; NORTRIPTYLINE; RAUWOLSCINE; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ALPHA ADRENERGIC STIMULATION; ARTICLE; BINDING SITE; CATECHOLAMINE NERVE CELL; CLINICAL ARTICLE; CLINICAL TRIAL; DEPRESSION; FEMALE; HUMAN; LONG TERM CARE; MALE; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR DENSITY; THROMBOCYTE;

ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BLOOD PLATELETS; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER; DOWN-REGULATION; FEMALE; FLUOXETINE; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; RECEPTORS, ADRENERGIC, ALPHA-2; STATISTICS; TREATMENT OUTCOME; UP-REGULATION; YOHIMBINE;

EID: 0033083149     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(98)00002-X     Document Type: Article

References (65)

1. Ansseau M., Scheyvaerts M., Doumont A., Poirrier R., Legros J.J., Franck G. Concurrent use of REM latency, dexamethasone suppression, clonidine, and apomorphine tests as biological markers of endogenous depression A pilot study . Psychiatry Res. 12:1984;261-272.
2. Arango V., Ernsberger P., Sved A.F., Mann J.J. Quantitative autoradiography of α1- and α2-adrenergic receptors in the cerebral cortex of controls and suicide victims. Brain Res. 630:1993;271-282.
3. Braddock L.E., Cowen P.J., Elliott J.M., Fraser S., Stump K. Binding of yohimbine and imipramine to platelets in depressive illness. Psychol Med. 16:1986;765-773.
4. Bunney W.E., Davis J.M. Norepinephrine in depressive reactions. Arch Gen Psychiatry. 13:1965;483-494.
5. Campbell I.C., McKernan R.M., Chekley S.A., Glass I.M., Thompson C., Shur E. Characterization of platelet α2-adrenoceptors and measurement in control and depressed subjects. Psychiatry Res. 14:1985;17-31.
6. Carstens M.E., Engelbrecht A.H., Russell V.A., Aalbers C., Gagiano C.A., Chalton D.O., et al. Alpha-2 adrenoceptor levels on platelets of patients with major depressive disorders. Psychiatry Res. 18:1986;321-331.
7. Charney D.S., Heninger G.R., Sternberg D.E. Alpha-2 adrenergic receptor sensitivity and the mechanism of action of antidepressant therapy. Br J Psychiatry. 142:1983;265-275.
8. Cohen J. A coefficient of agreement for nominal scales. Ed Psychol Meas. 20:1960;37-46.
9. 3H yohimbine, a selective antagonist ligand . Life Sci. 28:1981;2705-2717.
10. Davis J.M., Koslow S.H., Gibbons R.D., Maas J.W., Bowden C.L., Casper R., et al. Cerebrospinal fluid and urinary biogenic amines in depressed patients and healthy controls. Arch Gen Psychiatry. 45:1988;705-717.
11. D'Hondt P., Maes M., Leysen J., Gommeren W., Scharpé S., Cosyns P. Binding of 3[H]paroxetine to platelets of depressed patients Seasonal differences and effects of diagnostic classification . J Affect Disord. 32:1994;27-35.
12. Esler M., Turbott J., Schwarz R., Leonard P., Bobik A., Skews H., et al. The peripheral kinetics of norepinephrine in depressive illness. Arch Gen Psychiatry. 39:1982;295-300.
13. Fillenz M. Noradrenergic Neurons. 1990;Cambridge University Press, New York.
14. Garcia-Sevilla J.A., Zis A.P., Hollingsworth P.J., Greden J.F., Smith C.B. Platelet α2-adrenergic receptors in major depressive disorder. Arch Gen Psychiatry. 38:1981;1327-1333.
15. Garcia-Sevilla J.A., Guimon J., Garcia-Vallejo P., Fuster M.J. Biochemical and functional evidence of supersensitive platelet alpha-2 adrenoceptors in major affective disorder. Arch Gen Psychiatry. 43:1986;51-57.
16. 3H-imipramine binding in elderly depressed patients. Life Sci. 40:1987;2137-2143.
17. Grossman F., Manji H.K., Potter W.Z. Platelet α2-adrenoreceptors in depression A critical examination [review] . J Psychopharmacol. 7:1993;4-18.
18. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 23:1960;56-61.
19. Healy D., Carney P.A., Leonard B.E. Monoamine-related markers of depression Changes following treatment . J Psychiatry Res. 17:1983;251-260.
20. Hieble J.P., Bondinell W.E., Ruffolo R.R. α- and β-adrenoceptors From the gene to the clinic: 1. Molecular biology and adrenoceptor classification . J Med Chem. 38:1995;3415-3444.
21. Jimenez-Rivera C.A., Segarra O., Santacana G., Hoffman T., Savage D.D., Weiss G.K. Chronic imipramine treatment induces downregulation of alpha-2 receptors in rat's locus coeruleus and A2 region of the tractus solitarius. Life Sci. 58:1996;287-294.
22. Kafka M.S., Paul S.M. Platelet α2-adrenergic receptors in depression. Arch Gen Psychiatry. 43:1986;91-95.
23. Kafka M.S., van Kammen D.P., Kleinman J.E., Nurnberger J.I., Siever L.J., Udhe T.W., et al. Alpha-adrenergic receptor function in schizophrenia, affective disorders and some neurological diseases. Comm Psychopharmacol. 4:1981;477-486.
24. Kafka M.S., Nurnberger J.I., Siever L., Targum S., Uhde T.W., Gershon E.S. Alpha-2 adrenergic receptor function in patients with unipolar and bipolar affective disorders. J Affect Disord. 10:1986;163-169.
25. Karege F., Bovier P., Widmer J., Gaillard J.-M., Tissot R. Platelet membrane alpha-2-adrenergic receptors in depression. Psychiatry Res. 43:1992;243-252.
26. 3H]Yohimbine binding to platelet α2-adrenoceptors in depression. J Affect Disord. 17:1989;219-228.
27. Lake C.R., Pickar D., Ziegler M.G., Lipper S., Slater S., Murphy D.L. High plasma norepinephrine levels in patients with major affective disorders. Am J Psychiatry. 139:1982;1315-1318.
28. Limberger N., Funk L., Trendelenburg A.U., Starke K. Subclassification of presynaptic α2-adrenoceptors α2-autoreceptors in rabbit atria and kidney . Naunyn Schmiedebergs Arch Pharmacol. 352:1995;31-42.
29. Maas J.W., Koslow S.H., Davis J., Katz M., Frazer A., Bowden C.L., et al. Catecholamine metabolism and disposition in healthy and depressed subjects. Arch Gen Psychiatry. 44:1987;337-344.
30. Maes M., Vandewoude M., Schotte M., Martin M., Blockx P. Positive relationship between the catecholaminergic turnover and the DST results in depression. Psychol Med. 20:1990;493-499.
31. Maes M., Minner B., Suy E., Vandervorst C., Raus J. Coexisting dysregulations of both the sympathoadrenal system and hypothalamic-pituitary-adrenal-axis in melancholia. J Neural Transm. 85:1991;195-210.
32. Maes M., Meltzer H.Y., Suy E., Minner B., Calabrese J., Cosyns P. Sleep disorders and anxiety as symptom profiles of sympathoadrenal system hyperactivity in major depression. J Affect Disord. 27:1993;197-207.
33. Matussek N., Ackenheil M., Hippius H., Muller F., Schroder H.-T., Schultes H., et al. Effect of clonidine on growth hormone release in psychiatric patients and controls. Psychiatry Res. 2:1980;25-36.
34. Meana J.J., Garcia-Sevilla J.A. Increased α2-adrenoceptor density in the frontal cortex of depressed suicide victims. J Neural Transm. 70:1987;377-381.
35. Mendlewicz J., Hirsh D., Sevy S., Surmont D., Papadimitriou G., De Maertelaer V. Alpha-2-adrenoceptor binding as a possible vulnerability marker for affective disorders. Neuropsychobiology. 22:1989;61-67.
36. Mitrius J.C., Micuni M., Arora R.C., Meltzer H.Y., U'Prichard D.C. Responsiveness of α2-receptors is decreased in platelets from depressed patients. Soc Neurosci Abstr. 9:1983;990.
37. 3H-rauwolscine . Biochem Pharmacol. 31:1982;2591-2595.
38. 3H-para-aminoclonidine binding to platelet adrenoceptors in depression. Prog Neuropsychopharmacol Biol Psychiatry. 12:1988;541-553.
39. Piletz J.E., Halaris A. Psychopharmacology of imidazoline and α2-adrenergic receptors Implications for depression . Crit Rev Neurobiol. 9:1994;29-66.
40. Piletz J.E., Schubert D.S.P., Halaris A. Evaluation of studies on platelet alpha2 adrenoceptors in depressive illness. Life Sci. 39:1986;1589-1616.
41. 3H-rauwolscine binding in platelets from depressed patients and healthy volunteers. Psychopharmacology (Berl). 79:1983;308-312.
42. Potter W.Z., Manji H.K. Catecholamines in depression An update . Clin Chem. 40:1994;279-287.
43. Roy A., Kafka M.S. Platelet adrenoceptors and prostaglandin responses in depressed patients. Psychiatry Res. 30:1989;181-189.
44. Roy A., Pickar D., De Jong J., Karoum F., Linnoila M. Norepinephrine and its metabolites in cerebrospinal fluid, plasma, and urine. Arch Gen Psychiatry. 45:1988;849-857.
45. Rudorfer M.V., Ross R.S., Linnoila M., Sherer M.A., Potter W.Z. Exaggerated orthostatic responsivity of plasma norepinephrine in depression. Arch Gen Psychiatry. 42:1985;1186-1192.
46. Schildkraut J.J. The catecholamine hypothesis of affective disorders A review of supporting evidence . Am J Psychiatry. 122:1965;509-522.
47. Siever L.J., Davis K.L. Overview Toward a dysregulation hypothesis of depression . Am J Psychiatry. 142:1985;1017-1031.
48. Siever L.J., Uhde T.W. New studies and perspectives on the noradrenergic receptor system in depression Effects of the α2-adrenergic agonist clonidine . Biol Psychiatry. 19:1984;131-156.
49. Siever L.J., Uhde T.W., Silberman E.K., Jimerson D.C., Aloi J.A., Post R.M., et al. Growth hormone response to clonidine as a probe of noradrenergic receptor responsiveness in affective disorder patients and controls. Psychiatry Res. 6:1982;171-183.
50. Smith C.B., Garcia-Sevilla J.A., Hollingworth P.J. Alpha 2-adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment. Brain Res. 210:1981;413-418.
51. Southwick S.M., Yehuda R., Giller E.L., Perry B.D. Platelet alpha-2-adrenergic receptor binding sites in major depressive disorder and borderline personality disorder. Psychiatry Res. 34:1990;193-203.
52. Spitzer R.L., Williams J.B.W., Gibbon M., First M.B. Structured Clinical Interview according to DSM-III-R. 1990;American Press, New York.
53. Spyraki C., Fibiger H.C. Functional evidence for subsensitivity of noradrenergic α2 receptors after chronic desipramine treatment. Life Sci. 27:1980;1863-1867.
54. Stahl S.M. Peripheral models for the study of neurotransmitter receptors in man. Psychopharmacol Bull. 21:1985;663-671.
55. Stanford S.C., Nutt D.J., Cowen P.J. Comparison of the effects of chronic desmethylimipramine administration on α2 and β adrenoceptors in different regions of rat brain. Neuroscience. 8:1983;161-164.
56. Sugrue M.F. Chronic antidepressant therapy and associated changes in central monoaminergic receptor functioning. Pharamceut Ther. 21:1983;1-33.
57. Sugrue M.F. Improvement with antidepressants Timing and relationship to biochemical events . Psychopharmacol Bull. 21:1985;619-622.
58. Svensson T.H., Usdin T. Alpha-adrenoceptor mediated inhibition of brain noradrenergic neurons after acute and chronic treatment with tricyclic antidepressants. Kopin I.J., Barchas J. Catecholamines Basic and Clinical Frontiers . 1979;672-674 Pergamon Press, Oxford.
59. 3H-imipramine binding and plasma cortisol level in depression. Biol Psychiatry. 26:1989;52-60.
60. Thase M.E., Rush A.J. Treatment-resistant depression. Bloom F.E., Kupfer D.J. Psychopharmacology, the Fourth Generation of Progress. 1995;1081-1098 Raven Press, New York.
61. 3H UK-14, 304, in depressed patients and matched controls. Eur J Pharmacol. 126:1986;329-332.
62. Veith R.C., Lewis N., Linares O.A., Barnes R.F., Raskind M.A., Villacres E.C., et al. Sympathetic nervous system activity in major depression Basal and desipramine-induced alterations in plasma norepinephrine kinetics . Arch Gen Psychiatry. 51:1994;411-422.
63. Werstiuk E.S., Auffarth S.E., Coote M., Gupta R.N., Steiner M. Platelet α2-adrenergic receptors in depressed patients and healthy volunteers The effects of desipramine . Pharmacopsychiatry. 25:1992;199-206.
64. 3H-yohimbine . Psychiatry Res. 20:1987;107-116.
65. Wood K., Coppen A. Platelet α-adrenergic sensitivity in depressive illness. Adv Biol Psychiatry. 7:1981;85-89.