The kinetics and mechanism of Corynebacterium glutamicum aggregate breakup in bioreactors

Chemical Engineering Science

Volumn 54, Issue 4, 1999, Pages 441-454

  Illing, Suzi ^a   Harrison, Susan T L ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Aeration; Agitation; Breakage; Cell aggregates; Cell death; Size distribution

Indexed keywords

BIOREACTOR; CORYNEBACTERIUM GLUTAMICUM;

AGGLOMERATION; BACTERIA; BUBBLES (IN FLUIDS); CELL CULTURE; MATHEMATICAL MODELS; TURBULENCE;

AGGREGATE BREAKUP; AGITATION; CELL AGGREGATES;

BIOREACTORS;

AERATION; AGITATION; BACTERIUM; BIOREACTOR;

EID: 0033082730     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2509(98)00253-X     Document Type: Article

References (49)

1. Al-Rubeai, M., Singh, R.P., Emery, A.N., & Zhang, Z. (1995a). Cell cycle and cell size dependence of susceptibility to hydrodynamic forces. Biotechnol. Bioengng, 46, 8-92.
2. Al-Rubeai, M., Singh, R.P., Goldman, M.H., & Emery, A.N. (1995b). Death mechanisms of animal cells in conditions of intensive agitation. Biotechnol. Bioengng, 45, 463-472.
3. Bates, R.L., Fondy, P.L., & Corpstein, R.R. (1963). An examination of some geometric parameters of impeller power. Ind. Engng Chem. Process Des. Develop., 2, 310-314.
4. Bhavaraju, S.M., Russel, T.W.F., & Blanch, H.W. (1978). The design of gas sparged devices for viscous liquid systems. A.I.Ch.E. J., 24, 454-466.
5. Boulton-Stone, J.M., & Blake, J.R. (1993). Gas bubbles bursting at a free surface. J. Fluid Mech., 254, 437-466.
6. Brown, D.L., & Glatz, C.E. (1987). Aggregate breakup in protein precipitation. Chem. Engng Sci., 42, 1831-1839.
7. Bryant, R.S., & Sadeghzadeh, S. (1979). Proceedings Of 4th European Conference on Mixing, University of York, York, England, BHRA Fluid Engng, Cranfield, England (p. 325).
8. Calderbank, P.H. (1958). Physical rate processes in industrial fermentation. II. Mass transfer coefficients in gas liquid contacting with and without mechanical agitation. Trans. Inst Chem. Engrs, 36, 443.
9. Cutter, L.A. (1966). Flow and turbulence in a stirred tank. A.I.Ch.E. J., 12, 35-43.
10. Dunlop, E.H., & Namdev, P.K. (1994). Effect of fluid forces on plant cell suspensions. Chem. Engng Sci., 49, 2263-2276.
11. Dussap, G., & Gros, J.B. (1982). Energy consumption and interfacial mass transfer area in an airlift. Chem. Engng J., 25, 151-162.
12. Einsele, A. (1978). Scaling up bioreactors. Process Biochem., 13, 13-14.
13. Fowler, J.D., & Robertson, C.R. (1991). Metabolic behaviour of immobilized aggregates of Escherichia coli of varying mechanical stress. Appl. Environ. Microbiol., 57, 93-101.
14. Handa-Corrigan, A., Emery, A.N., & Spier, R.E. (1989). Effect of gas liquid interfaces on the growth of suspended mammalian cells; Mechanisms of cell damage by bubbles. Enzyme Microbial Technol., 11, 230-235.
15. Hicks, R.W., & Gates, L.E. (1976). How to select turbine agitators for dispersing gas into liquids. Chem. Engng, 83, 141-148.
16. Hinze (1959). Fundamentals of the hydrodynamic mechanism of splitting up in dispersion processes. A.I.Ch.E. J., 1, 289-295.
17. Holmes, D.B., Voncken, R.M., & Dekker, J.A. (1964). Fluid flow in turbine-stirred, baffled tanks-I. Chem Engng Sci., 19, 201-208.
18. Illing, S. (1996). An Investigation Of the Effect Of Hydrodynamic Stress on the the Growth, Morphology and Metabolism Of Microorganisms. Ph.D. thesis, Chemical Engineering, University of Cape Town.
19. Joshi, J.B., Pandit, A.B., & Sharma, M.M. (1982). Mechanically agitated gas-liquid reactors. Chem. Engng Sci., 37, 813-844.
20. Kunas, K.T., & Papoutsakis, E.T. (1990). Damage mechanisms of suspended animal cells in agitated bioreactors with and without bubble entrainment. Biotechnol. Bioengng, 36, 476-483.
21. Laufer, J. (1954). The Structure of Turbulence in Fully Developed Pipe Flow. National Advisory Committee for Aeronautics Report, (Vol. 1174, pp. 1-18).
22. Levich, V.G. (1962). Physicochemical Hydrodynamics. New York: Prentice-Hall.
23. Majumdar, A.S., Huang, B., Wolf, D., Weber, M.E., & Douglas, W.J.M. (1970). Turbulence parameters in a stirred tank. Can. J. Chem. Engng, 48, 475-483.
24. Matsuo, T., & Unno, H. (1981). Forces acting on floc and strength of floc. J. Environ. Engng Div., 107, 527-545.
25. Mersmann, A., Schneidet, G., Volt, H., & Wenzig, E. (1990). Selection and design of aerobic bioreactors. Chem. Engng Technol., 13, 357-370.
26. Michel, B.J., & Miller (1962). Power requirements of gas liquid agitated systems. A.I.Ch.E. J., 13, 262-266.
27. Moreira, J.L., Cruz, P.E., Sanatana, P.C., Aunins, J.G., & Carrondo, M.J.T. (1995). Formation and disruption of animal cell aggregates in stirred vessels: Mechanisms and kinetic studies. Chem. Engng Sci., 50, 2747-2764.
28. Mukutaka, S., Kataoka, H., & Takahashi, J. (1981). Circulation time and degree of fluid exchange between the upper and lower circulation regions in a stirred vessel with a dual impeller. J. Fermentation Technol., 59, 303-307.
29. O'Connel, F.P., & Mack, D.E. (1950). Simple turbines in fully baffled tanks. Chem. Engng Prog., 46, 358-362.
30. Okomoto, Y., Nishikawa, M., & Hashimoto, K. (1981). Energy dissipation rate distribution in mixing vessels and its effects on liquid-liquid dispersion and solid liquid mass transfer. Int. Chem. Engng, 21, 88-94.
31. Parker, D.S., Asce, A.M., Kaufman, W.J., Asce, M., & Jenkins, D. (1972). Floc breakup in turbulent flocculation processes. J. Sanitary Engng Div., 98, 79-99.
32. Ranz, W.E. (1958). Electrolytic methods for measuring water velocities. A.I.Ch.E. J., 4, 338-342.
33. Rao, M.A., & Brodkey, R.S. (1972). Continuous flow stirred tank turbulence parameters in the impeller stream. Chem. Engng Sci., 27, 137-156.
34. Reuß, M. (1988). Influence of mechanical stress on the growth of Rhizopus nigricans in stirred bioreactors. Chem. Engng Technol., 11, 176-187.
35. Rushton, J.H., Costich, E.W., & Everett, H.J. (1950). Power characteristics of mixing impellers. Chem. Engng Prog., 46, 467-476.
36. Shamlou, P.A., Jones, A.G., & Djamarani, K. (1990). Hydrodynamics of secondary nucleation in suspension crystallization. Chem. Engng Sci., 45, 1405-1416.
37. Shamlou, P.A., Makagiansar, H.Y., Ison, A.P., & Lilly, M.D. (1994a). Turbulent breakage of filamentous microogranisms in submerged culture in mechanically stirred bioreactors. Chem. Engng Sci., 49, 2621-2631.
38. Shamlou, P.A., Stavrindes, N., Titchener-Hooker, N., & Hoare, M. (1994b). Growth-independent breakage frequency of protein precipitates in turbulently agitated bioreactors. Chem. Engng Sci., 49, 2647-2656.
39. Shamlou, P.A., Stavrinides, S., Titchener-Hooker, N., & Hoare, M. (1996). Turbulent breakage of protein precipitates in mechanically stirred bioreactors. Bioprocess Engng, 14, 237-243.
40. Smith, J.J., Lilly, M.D., & Fox, R.I. (1990). The effect of agitation on the morphology and penicillin production of penicillin chrysogenum. Biotechnol. Bioengng, 35, 1011-1023.
41. Thomas, D.G. (1964). Turbulent disruption of flocs in small particle size suspensions. A.I.Ch.E.J., 10, 517-523.
42. Toma, M.K., Ruklisha, M.P., Vanags, J.J., Zeltina, M.O., Leite, M.P., Galinina, N.I., Viesturs, U.E., & Tengerdy, R.P. (1991). Inhibition of microbial growth and metabolism by excess turbulence. Biotechnol. Bioengng, 22, 237-241.
43. Vanags, J.J., Rikmams, M.A., Ushkans, E.J., & Viesturs, U.E. (1990). Stirring characteristics in bioreactors. A.I.Ch.E. J., 36, 1361-1369.
44. Van Suijdam, J.C., & Metz, B. (1981). Influence of engineering variables on the morphology of filamentous molds. Biotechnol. Bioengng, 23, 111-148.
45. Wase, D.A.J., & Patel, Y.R. (1985). Variations in the volumes of microbial cells with changes in the agitation rate of chemostat cultures. J. General Microbiol., 131, 725-728.
46. Wu, H., & Patterson, G.K. (1989). Laser-doppler measurements of turbulent-flow parameters in a stirred mixer. Chem. Engng. Sci., 44, 2207-2220.
47. Zhang, S., Handa-Corrigan, A., & Spier, R.E. (1992). Foaming and media surfactant effects on the cultivation of animal cells in stirred and sparged bioreactors. J. Biotechnol., 25, 289-306.
48. Zhang, Z., Al-Rubeai, M., & Thomas, C.R. (1993). Estimation of disruption of animal cells by turbulent capillary flow. Biotechnol. Bioengng, 42, 987-993.
49. Zhang, Z., Al-Rubeai, M., & Thomas, C.R. (1995). Preliminary modelling of animal cell disruption in a closed stirred tank. The 1995 Research Event/First European Conference (Pp. 1088-1090).