Growth hormone binding protein correlates strongly with leptin and percentage body fat in GH-deficient adults, is increased by GH replacement but does not predict IGF-I response

Growth Hormone and IGF Research

Volumn 9, Issue 1, 1999, Pages 35-40

  Barnard, R ^a   Livesey, J H ^a   Veveris, T ^b   Espiner, E A ^a   Donald, R A ^a  

^a CHRISTCHURCH HOSPITAL   (New Zealand)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Body fat; Growth hormone binding protein; Leptin

Indexed keywords

GROWTH HORMONE; GROWTH HORMONE BINDING PROTEIN; GROWTH HORMONE RECEPTOR; LEPTIN; SOMATOMEDIN C;

ADULT; AGED; ARTICLE; BODY COMPOSITION; BODY FAT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONAL THERAPY; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGULATORY MECHANISM; SCORING SYSTEM;

EID: 0033080884     PISSN: 10966374     EISSN: None     Source Type: Journal    
DOI: 10.1054/ghir.1998.0084     Document Type: Article

References (39)

1. Leung D. W., Spencer S. A., Cachaines G., Hammonjd R. G., Collins C., Henzel W. J., Barnard R., Waters M. J., Wood W. I. Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature. 330:1987;537-543.
2. Baumann G., Stolar M. W., Amburn K., Barsano C. P., DeVries B. C. A specific growth hormone-binding protein in human plasma: initial characterization. J Clin Endocrinol Metab. 62:1986;134-141.
3. Fairhall K. M., Carmignac D. F., Robinson I. C. Growth hormone (GH) binding protein and GH interactionsin vivo. Endocrinology. 131:1992;1963-1969.
4. Ho K. K. Y., Jorgensen J. O. L., Valiontis E., Waters M. J., Rajkovic I. A., Christiansen J. S. Different modes of growth hormone (GH) administration do not change GH binding protein activity in man. Clin Endocrinol. 38:1993;143-148.
5. Roelen C. A., Donker G. H., Thijssen J. H., Koppeschaar H. P., Blankenstein M. A. High affinity growth hormone binding protein in plasma of patients with acromegaly and the effect of octreotide treatment. Clin Endocrinol. 37:1992;373-378.
6. Counts D. R., Gwirtsman H., Carlsson L. M. S., Lesem M., Cutler G. B. Jr. The effect of anorexia nervosa and refeeding on growth-hormone binding protein, the insulin-like growth factors (IGFs), and the IGF-binding proteins. J Clin Endocrinol Metab. 75:1992;762-767.
7. Hochberg Z., Hertz P., Colin V., Ish-Shalom S., Yeshurun D., Youdim M. B. H., Amit T. The distal axis of growth hormone (GH) in nutritional disorders: GH-binding protein, insulin-like growth factor-1, and IGF-I receptors in obesity and anorexia nervosa. Metabolism. 41:1992;106-112.
8. Postel-Vinay M-C., Saab C., Gourmelen M. Nutritional staus and growth hormone-binding protein. Hormone Res. 44:1995;177-181.
9. Barnard R., Chan F-Y., McIntyre H. D. Growth hormone-binding protein in normal and pathological gestation: correlations with maternal diabetes and fetal growth. J Clin Endocrinol Metab. 82:1997;1879-1884.
10. Fisker S., Vahl N., Jorgensen J. O. L., Christiansen J. S., Orskov H. Abdominal fat determines growth hormone-binding protein levels in healthy nonobese adults. J Clin Endocrinol Metab. 81:1997;123-128.
11. Roelen C. A. M., Koppeschaar H. P. F., de Vries W. R., Snel Y. E. M., Doerga M. E., Zelissen P. M. J., Thijssen J. H. H., Blankenstein M. A. Visceral adipose tissue is associated with circulating high-affinity growth hormone-binding protein. J Clin Endocrinol Metab. 82:1997;760-764.
12. Binnerts A., Deurenberg P., Swart G. R., Wilson J. H. P., Lamberts S. W. J. Body composition in growth hormone deficient adults. Am J Clin Nutr. 55:1992;918-923.
13. Amato G., Carella C., La Montagna G., Cittadini A., Sabatini D., Marciano-Mone C., Sacca L., Bellastella A. Body composition, bone metabolism, and heart structure and function in growth hormone (GH) -deficient adults before and after GH therapy at low doses. J Clin Endocrinol Metab. 77:1993;1671-1676.
14. Rosen T., Bosaeus I., Tolli J., Lindstedt G., Bengtsson B. Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency. Clin Endocrinol. 38:1993;63-71.
15. Salomon F., Cuneo R. C., Hesp R., Sonksen P. H. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med. 321:1989;1797-1803.
16. Orme S. M., Sebastian J. P., Oldroyd B., Stewart S. P., Grant P. J., Stickland M. H., Smith M. A., Belchetz P. E. Comparison of measures of body composition in a trial of low dose growth hormone therapy. Clin Endocrinol. 37:1992;453-459.
17. Snel Y. E. M., Doerga M. E., Brummer R-J. M., Zelissen P. M. J., Koppeschaar H. P. F. Magnetic resonance imaging-assessed adipose tissue and serum lipid and insulin concentrations in growth hormone-deficient adults. Arterio Thromb Vasc Biol. 15:1995;1543-1548.
18. Beshyah S. A., Rutherford O. M., Thomas E., Murphy M., Johnston D. G. Assessment of regional body composition by dual energy X-ray absorptiometry in hypopituitary adults before and during growth hormone treatment. Endocrinol Metab. 2:1995;147-155.
19. Florkowski C. M., Collier G. R., Zimmet P. Z., Livesey J. H., Espiner E. A., Donald R. A. Low-dose growth hormone replacement lowers plasma leptin and fat stores without affecting body mass index in adults with growth hormone deficiency. Clin Endocrinol. 45:1996;769-773.
20. Carlsson L. M. S., Rowland A. M., Clark R. G., Gesundheit N., Wong W. L. Ligand-mediated immunofunctional assay for quantitation of growth-hormone binding protein in human blood. J Clin Endocrinol Metab. 73:1991;1216-1223.
21. Rajkovic I. A., Valiontis E., Ho K. K. Y. Direct quantitation of growth hormone binding protein (rGHBP) in human serum by a ligand immunofunctional assay: comparison with immunoprecipitation and chromatographic methods. J Clin Endocrinol Metab. 78:1994;772-777.
22. Breier B. H., Milsom S. R., Blum W. F., Schwander J., Gallaher B. W., Gluckman P. D. Insulin-like growth factors and their binding proteins in plasma and milk after growth hormone-stimulated galactopoiesis in normally lactating women. Acta Endocrinol. 129:1993;427-435.
23. Rasat R., Livesey J. H., Espiner E. A., Abbott G. D., Donald R. A. IGF-I and IGFBP-3 screening for disorders of Growth Hormone Secretion. N Zeal Med J. 109:1996;156-159.
24. Mazess R., Barden H. S., Bisek J. P., Hanson J. Dual energy x-ray absorptiometry for total and regional bone-mineral and soft-tissue composition. Am J Clin Nutr. 51:1990;1106-1112.
25. Jennrich R., Sampson P., Frane J. P2V analysis of variance and covariance including repeated measures. BMD statistical software manual. 1983;University of California Press, Los Angeles. p. 359-387.
26. Florkowski C. M., Walmsley T., Geroge P. M., Livesey J. H., Espiner E. A., Donald R. A. The effect of growth hormone on age-standardized IGF-I, IGFBP-3 and biochemical parameters of bone turnover in adult hypopituitarism. Endocrinol Metab. 4:1997;129-134.
27. Kennedy G. C. Role of depot fat in hypothalamic control of food intake in rat. Proc Royal Soc London B. 140:1953;578-592.
28. Mannor D. A., Winer L. M., Shaw M. A., Baumann G. Plasma growth hormone (GH) -binding proteins: effect on GH binding to receptors and GH action. J Clin Endocrinol Metab. 73:1991;30-34.
29. Lim L., Spencer S. A., Waters M. J. Regulation of growth hormone (GH) bioactivity by a recombinant human GH-binding protein. Endocrinology. 127:1990;1287-1291.
30. Tzanela M., Wagner C., Tannenbaum G. S. Recombinant human growth hormone-binding protein fails to enhance thein vivo. Endocrinology. 138:1997;5316-5324.
31. Johannsson G., Bjarnason R., Bramnert M., Carlsson L. M. S., Degerblad M., Manhem P., Rosen T., Thoren M., Bengtsson B-A. The individual responsiveness to growth hormone (GH) treatment in GH-deficient adults is dependent on the level of GH-binding protein, body mass index, age and gender. J Clin Endocrinol Metab. 81:1996;1575-1581.
32. Hochberg Z., Barkey R. J., Even L., Peleg I., Youdim M. B. H., Amit T. The effect of human growth hormone therapy on GH binding protein in GH-deficeint children. Acta Endocrinol. 125:1991;23-27.
33. Boguszewski M., Bjarnson R., Rosberg S., Carlsson L. M. S., Albertson-Wikland K. Growth hormone (GH) -binding protein in prepubertal short children born small for gestational age: effects of growth hormone treatment. J Clin Endocrinol Metab. 82:1997;1014-1019.
34. Tauber M., De Bouet Du Portal H., Sallerin-Caute B., Rochiccioli P., Bastide R. Differential regulation of serum growth hormone (GH) -binding protein during continuous infusion versus daily injection of recombinant human GH in GH-deficient children. J Clin Endocrinol Metab. 76:1993;1135-1139.
35. Tonshoff B., Cronin M. J., Reichert M., Haffner D., Wingen A-M., Blum W. F. The European study group for nutritional treatment of chronic renal failure in childhood, and members of the German study group for growth hormone treatment in chronic renal failure. Reduced concentration of serum growth hormone binding protein in children with chronic renal failure: correlation with GH insensitivity. J Clin Endocrinol Metab. 82:1997;1007-1013.
36. Maheshwari H. G., Rifkin I., Butler J., Norman M. Growth hormone binding protein in patients with renal failure. Acta Endocrinol. 127:1992;485-488.
37. Gelander L., Bjarnason R., Carlsson L. M., Albertsson-Wikland K. Growth hormone-binding protein levels over one year in healthy prepubertal children: intraindividual variation and correleation with height velocity. Paediatr Res. 43:1998;256-261.
38. Kratzsch J., Dehmel B., Pulzer F., Keller E., Englaro P., Blum W. F., Wabitsch M. Increased serum GHBP levels in obese pubertal children and adolescents: relationship to body composition, leptin and indicators of metabolic disturbances. Int J Obes. 21:1997;1130-1136.
39. Clement K., Lahlou N., Cabrol S., Pelloux V., Cassuto D., Gourmelen M., Dina C., Chambaz J., Lacorte J.-M., Basdevant A., Bougneres P., Lebouc Y., Froguel P., Guy-Grand B. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 392:1998;398.