Centriacinar remodeling and sustained procollagen gene expression after exposure to ozone and nitrogen dioxide

American Journal of Respiratory Cell and Molecular Biology

Volumn 20, Issue 2, 1999, Pages 303-311

  Farman, Cindy A ^a   Watkins, Karen ^a   Van Hoozen, Brent ^a   Last, Jerold A ^a   Witschi, Hanspeter ^a   Pinkerton, Kent E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

MESSENGER RNA; NITROGEN DIOXIDE; OZONE; PROCOLLAGEN;

ANIMAL; ARTICLE; DNA PROBE; DRUG EFFECT; GENE EXPRESSION; GENETICS; IN SITU HYBRIDIZATION; MALE; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; DNA PROBES; GENE EXPRESSION; IN SITU HYBRIDIZATION; MALE; NITROGEN DIOXIDE; OZONE; PROCOLLAGEN; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0033074469     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.20.2.3269     Document Type: Article

References (27)

1. Last, J. A., T. R. Gelzeichter, K. E. Pinkerton, R. M. Walker, and H. Witschi. 1993. A new model of progressive pulmonary fibrosis in rats. Am. Rev. Respir. Dis. 148:487-494.
2. Farman, C. A., K. E. Pinkerton, P. Rajini, H. Witschi, and J. A. Last. 1997. Evolution of lung lesions in rats exposed to mixtures of ozone and nitrogen dioxide. Inhalation Toxicol. 9:647-677.
3. Freeman, G., L. T. Juhos, N. J. Furiosi, R. Mussenden, R. J. Stephens, and M. J. Evans. 1974. Pathology of pulmonary disease from exposure to interdependent ambient gases (nitrogen dioxide and ozone). Arch. Environ. Health 29:203-210.
4. Gelzleichter, T. R., H. Witschi, and J. A. Last. 1992. Concentration-response relationships of rat lungs to exposure to oxidant air pollutants: a critical test of Habers' Law for ozone and nitrogen dioxide. Toxicol. Appl. Pharmacol. 112:73-80.
5. Last, J. A., M. D. Jennings, L. W. Schwartz, and C. E. Cross. 1977. Glycoprotein secretion by tracheal explants cultured from rats exposed to ozone. Am. Rev. Respir. Dis. 116:695-703.
6. Schwartz, L. W., D. L. Dungworth, M. G. Mustafa, B. K. Tarkington, and W. S. Tyler. 1976. Pulmonary responses of rats to ambient levels of ozone: effects of 7-day intermittent or continuous exposure. Lab. Invest. 34:565-578.
7. Scherle, W. 1970. A simple method for volumetry of organs in quantitative stereology. Mikroskopie 26:57-60.
8. Pinkerton, K. E., R. R. Mercer, C. G. Plopper, and J. D. Crapo. 1992. Distribution of injury and microdosimetry of ozone in the ventilatory unit of the rat. J. Appl. Physiol. 73:817-824.
9. Pinkerton, K. E., D. E. Dodge, J. Cederdahl-Demmler, V. J. Wong, J. Peake, C. J. Haselton, P. W. Mellick, G. Singh, and C. G. Plopper. 1993. Differentiated bronchiolar epithelium in alveolar ducts of rats exposed to ozone for 20 months. Am. J. Pathol. 142:947-956.
10. Armstrong, L. C., K. Watkins, K. E. Pinkerton, and J. A. Last. 1994. Collagen mRNA content and distribution in the lungs of rats exposed to ozone. Am. J. Respir. Cell Mol. Biol. 11:25-34.
11. Snedecor, G. W., and W. G. Cochran. 1967. Statistical Methods. Iowa State University Press, Ames, IA.
12. Barr, B. C., D. M. Hyde, C. G. Plopper, and D. L. Dungworth. 1988. Distal airway remodeling in rats chronically exposed to ozone. Am. Rev. Respir. Dis. 137:924-938.
13. Gelzleichter, T. R., H. Witschi, and J. A. Last. 1992. Synergistic interaction of nitrogen dioxide and ozone on rat lungs: acute responses. Toxicol. Appl. Pharmacol. 116:1-9.
14. Parks, W. C., and J. D. Roby. 1994. Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies: IV. Effects on expression of extracellular matrix genes. Res. Rep. Health Eff. Inst. 65:3-20; discussion 21-29.
15. Last, J. A., T. Gelzleichter, J. Harkema, W. C. Parks, and P. Mellick. 1993. Effects of 20 months of ozone exposure on lung collagen in Fischer 344 rats. Toxicology 84:83-102.
16. Frankel, F. R., J. R. Steeger, V. V. Damiano, M. Sohn, D. Oppenheim, and G. Weinbaum. 1991. Induction of unilateral pulmonary fibrosis in the rat by cadmium chloride. Am. J. Respir. Cell Mol. Biol. 5:385-394.
17. Kelley, J., L. Chrin, S. Shull, D. W. Rowe, and K. R. Cutroneo. 1985. Bleomycin selectively elevates mRNA levels for procollagen and fibronectin following acute lung injury. Biochem. Biophys. Res. Commun. 131:836-843.
18. Kirk, J. M., B. E. Heard, I. Kerr, M. Turner-Warwick, and G. J. Laurent. 1984. Quantitation of types I and III collagen in biopsy lung samples from patients with cryptogenic fibrosing alveolitis. Collagen Related Research 4: 169-182.
19. Last, J. A., A. D. Siefkin, and K. M. Reiser. 1983. Type I collagen content is increased in lungs of patients with adult respiratory distress syndrome. Thorax 38:364-368.
20. Last, J. A., K. M. Reiser, W. S. Tyler, and R. B. Rucker. 1984. Long-term consequences of exposure to ozone: I. Lung collagen content. Toxicol. Appl. Pharmacol. 72:111-118.
21. Nerlich, A. G., M. L. Nerlich, and P. K. Muller. 1987. Pattern of collagen types and molecular structure of collagen in acute post-traumatic pulmonary fibrosis. Thorax 42:863-869.
22. Reiser, K. M., and J. A. Last. 1981. Pulmonary fibrosis in experimental acute respiratory disease. Am. Rev. Respir. Dis. 123:58-63.
23. Seyer, J. M., F. T. Hutcheson, and A. H. Kang. 1976. Collagen polymorphism in idiopathic chronic pulmonary fibrosis. J. Clin. Invest. 57:1498-1507.
24. Shoemaker, C. T., K. M. Reiser, B. W. Goetzman, and J. A. Last. 1984. Elevated ratios of type I/III collagen in the lungs of chronically ventilated neonates with respiratory distress. Pediatr. Res. 18:1176-1180.
25. Vuorio, E. I., J. K. Makela, T. K. Vuorio, A. Poole, and J. C. Wagner. 1989. Characterization of excessive collagen production during development of pulmonary fibrosis induced by chronic silica inhalation in rats. Br. J. Exp. Pathol. 70:305-315.
26. Adams, S. L. 1989. Collagen gene expression. Am. J. Respir. Cell Mol. Biol. 1:161-168.
27. Bienkowski, R. S., and M. G. Gotkin. 1995. Control of collagen deposition in mammalian lung. Proc. Soc. Exp. Biol. Med. 209:118-140.