Thrombin activates the growth, cell-cycle kinetics, and clustering of human dental pulp cells

Journal of Endodontics

Volumn 25, Issue 2, 1999, Pages 118-122

  Chang, Mei Chi ^a   Jeng, Jiiang Huei ^b   Lin, Chun Pin ^b   Lan, Wan Hong ^b   Tsai, William ^c   Hsieh, Chi Chuan ^b,d  

^a Team of Biomedical Science   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MITOGENIC AGENT; PROSTAGLANDIN E; THROMBIN;

ARTICLE; BIOSYNTHESIS; CELL AGGREGATION; CELL CULTURE; CELL CYCLE; CELL DIVISION; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; HUMAN; METABOLISM; REGRESSION ANALYSIS; TOOTH PULP;

CELL AGGREGATION; CELL CYCLE; CELL DIVISION; CELLS, CULTURED; DENTAL PULP; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MITOGENS; PROSTAGLANDINS E; REGRESSION ANALYSIS; THROMBIN;

EID: 0033073555     PISSN: 00992399     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0099-2399(99)80009-0     Document Type: Article

References (20)

1. Selzer S, Bender IB. In: Selzer S, Bender IB, eds. The dental pulp: biologic considerations in dental procedures. Philadelphia: JB Lippincott Company, 1984.
2. Cox CF, Bergenholtz G. Healing sequence in capped inflamed dental pulps of Rhesus monkeys. Int Endod J 1986;19:113-20.
3. Yamamura T. Differentiation of pulpal cells and inductive influences of various matrices with reference to pulpal wound healing. J Dent Res 1985; 64(Special Issue):530-40.
4. Altieri DC. Coagulation assembly on leukocytes in transmembrane signaling and cell adhesion. Blood 1993;81:569-79.
5. Sundqvist G, Rosenquist JB, Lerner UH. Effects of bradykinin and thrombin on prostaglandin formation, cell proliferation and collagen biosynthesis in human dental pulp fibroblasts. Arch Oral Biol 1995;40:247-56.
6. Chang MC, Lin CP, Huang TF, Lan WH, Lin YL, Hsieh CC, Jeng JH. Thrombin-induced DNA synthesis of cultured human dental pulp cells is dependent on its proteolytic activity and modulated by prostaglandin E2. J Endodon 1998;24:709-13.
7. Chang MC, Lan WH, Chan CP, Lin CP, Hsieh CC, Jeng JH. Serine protease activity is essential for thrombin-induced protein synthesis in cultured human dental pulp cells: modulation roles of prostaglandin E2. J Oral Pathol Med 1997;27:23-9.
8. Chandler JE, Messer HH, Ellender G. Cytotoxicity of gallium and indium ions compared with mercuric ion. J Dent Res 1994;73:1554-9.
9. Zamai L, Falcieri E, Zauli G, Cataldi A, Vitale M. Optimal detection of apoptosis by flow cytometry depends on cell morphology. Cytometry 1993; 14:891-7.
10. Nakashima N. Induction of dentin formation on canine amputated pulp by recombinant human bone morphogenetic proteins (BMP)-2 and -4. J Dent Res 1994;73:1515-22.
11. Francis CW, Markham RE, Barlow GH, Florack TM, Dobrzynski DM, Marder VJ. Thrombin activity of fibrin thrombi and soluble plasmic derivatives. J Lab Clin Med 1983;102:220-30.
12. Dawes KE, Gray AJ, Laurent GJ. Thrombin stimulates fibroblast chemotaxis and replication. Eur J Cell Biol 1993;61:126-30.
13. Fenton JW II. Regulation of thrombin generation and functions. Semin Thromb Haemost 1988;14:234-40.
14. Fager G. Thrombin and proliferation of vascular smooth muscle cells. Circ Res 1995;77:645-50.
15. Bachhuber BG, Sarembock IJ, Gimple LW, McNamara CA, Owens GK. Thrombin-induced mitogenesis in cultured aortic smooth muscle cells requires prolonged thrombin exposure. Am J Physiol 1995;268:C1141-7.
16. Pilcher BK, Kim DW, Carney DH, Tomasek J. Thrombin stimulates fibroblast-mediated collagen lattice contraction by its proteolytically activated receptor. Exp Cell Res 1994;211:368-73.
17. Pilcher BK, Levine NS, Tomasek J. Thrombin promotion of isometric contraction in fibroblasts: its extracellular mechanism of action. Plast Reconstr Surg 1995;96:1188-95.
18. Thoumine O, Ott A. Influence of adhesion and cytoskeletal integrity on fibroblast traction. Cell Motil Cytoskel 1996;35:269-80.
19. Mangkornkarn C, Steiner JC, Bohman R, Lindemann RA. Flow cytometric analysis of human dental pulp tissue. J Endodon 1991;17:49-53.
20. Camey DH, Mann R, Redlin WR, Pernia SD, Berry D, Heggers JP, Hayward PJ, Robson MC, Christie A, Annable C, Fenton JW II, Glenn KC. Enhancement of incisional wound healing and neovascularization in normal rats by thrombin and synthetic thrombin receptor activation peptides. J Clin Invest 1993;89:1469-77.