Histomorphometric Analysis of Optic Nerve Changes in Experimental Glaucoma

Journal of Glaucoma

Volumn 8, Issue 1, 1999, Pages 38-45

  Yücel, Yeni H ^a,c   Kalichman, Michael W ^b   Mizisin, Andrew P ^b   Powell, Henry C ^b   Weinreb, Robert N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Glaucoma; Glia; Histology; Morphometry; Optic nerve; Primates

Indexed keywords

ANIMAL; ARTICLE; CELL COUNT; CHRONIC DISEASE; COMPARATIVE STUDY; DISEASE MODEL; FOLLOW UP; GLAUCOMA; GLIA; INTRAOCULAR PRESSURE; MACACA; MYELINATED NERVE; OPTIC NERVE; OPTIC NERVE ATROPHY; PATHOLOGY;

ANIMALS; CELL COUNT; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; FOLLOW-UP STUDIES; GLAUCOMA; INTRAOCULAR PRESSURE; MACACA FASCICULARIS; NERVE FIBERS, MYELINATED; NEUROGLIA; OPTIC ATROPHY; OPTIC NERVE;

EID: 0033073181     PISSN: 10570829     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Anderson DR, Hoyt WF. Ultrastructure of intraorbital portion of human and monkey optic nerve. Arch Ophthalmol 1969;82:506-530.
2. Radius RL, Pederson JE. Laser-induced primate glaucoma. II. Histopathology. Arch Ophthalmol 1984;102:1693-1698.
3. Quigley HA, Addicks LA, Green WR. Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema and toxic neuropathy. Arch Ophthalmol 1982;100:135-146.
4. Jonas JB. Müller-Bergh JA, Sehlotzer-Schrehardt UM, Naumann GOH. Optic nerve fiber count and diameter of the retrobulbar optic nerve in normal and glaucomatous eyes. Graefes Arch Clin Exp Ophthalmol 1995;233:421-424.
5. Stroman GA, Stewart WC, Golnik KC, Curé JK, Olinger RE. Magnetic resonance imaging in patients with low-tension glaucoma. Arch Ophthamol 1995;113:168-172.
6. Quigley HA, Sanchez RM, Dunkelberger GR, L'Hernault NL, Baginski TA. Chronic glaucoma selectively damages large optic nerve fibers. Invest Ophthalmol Vis Sci 1987;28:913-920.
7. Gaasterland D, Kupfer C. Experimental glaucoma in the rhesus monkey. Invest Ophthalmol Vis Sci 1974;13:455-457.
8. Yucel YH, Gupta N, Kalichman MW, Mizisin A, Hare W, Lima M, Zangwill L, Weinreb R. Relationship of optic disc topography to optic nerve fiber number in glaucoma. Arch Ophthalmol 1998; 116:493-197.
9. Weibel ER. Stereological Methods: Practical Methods for Biological Morphometry. Volume 1. New York: Academic Press, 1980.
10. Gundersen HJG. Notes on the estimation of the numerical density of arbitrary profiles: the edge effect. J Microsc 1977;111:219-223.
11. Sivron T, Schwartz M. Glial cell types, lineages and responses to injury in rat and fish: implication for regeneration. Glia 1995;13: 157-165.
12. Klocker N, Braunling F, Isenmann S, Bahr M. In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells. Neuroreport 1997;8:3439-3442.
13. Sanchez RM, Dunkelberger GR, Quigley HA. The number and diameter distribution of axons in the monkey optic nerve. Invest Ophthalmol Vis Sci 1986;27:1342-1350.
14. Jonas JB, Müller-Bergh JA, Sehlotzer-Schrehardt UM, Naumann GOH. Histomorphometry of the human optic nerve. Invest Ophthalmol Vis Sci 1990;31:736-744.
15. Mikelberg FS, Drance SM, Schulzer M, Yidegiligne HM, Weis MM. The normal human optic nerve: axon count and axon diameter distribution. Ophthalmology 1989;96:1325-1328.
16. Naito J. Morphological and quantitative analysis of the fascicular pattern of monkey optic nerve. Cell Tissue Res 1996;283:255-261.
17. Parravano JG, Toledo A, Kucharczyck W. Dimensions of optic nerves, chiasm, and tracts: MR quantitative comparison between patients with optic atrophy and normals. J Cornput Assist Tomogr 1993;17:688-690.
18. Gass A, Barker GJ, MacManus D, Sanders M, Riordan-Eva P, Tofts PS, et al. High resolution magnetic resonance imaging of the anterior visual pathway in patients with optic neuropathies using fast spin echo and phased array local coils. J Neurol Neurosurg Psychiatry 1995;58:562-569.
19. Wolff SD, Balaban RS. Magnetization transfer contrast (MTC) and tissue proton relaxation in vivo. Magn Reson Med 1989;10:135-144.
20. Barnes D, Munro PMG, Youl BD. The long-standing MS lesion: a quantitative MRI and electron microscope study. Brain 1991;110: 636-639.