Cysteine transport in melanosomes from murine melanocytes

Pigment Cell Research

Volumn 12, Issue 1, 1999, Pages 4-12

  Potterf, S Brian ^a,d   Virador, Victoria ^a   Wakamatsu, Kazumasa ^b   Furumura, Minao ^a   Santis, Chie ^a   Ito, Shosuke ^b   Hearing, Vincent J ^a,c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FUJITA HEALTH UNIVERSITY   (Japan)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Cysteine; Melanin; Melanosomes; Pigmentation; Transport

Indexed keywords

CARRIER PROTEIN; CYSTEINE; EUMELANIN; GLUTATHIONE; MELANIN; PHEOMELANIN; SULFUR; TYROSINE;

ANIMAL; ARTICLE; CELL CULTURE; MELANOCYTE; MELANOSOME; METABOLISM; MOUSE; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELLS, CULTURED; CYSTEINE; GLUTATHIONE; MELANINS; MELANOCYTES; MELANOSOMES; MICE; SULFUR RADIOISOTOPES; TYROSINE;

EID: 0033073156     PISSN: 08935785     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0749.1999.tb00502.x     Document Type: Article

References (55)

1. Agrup, G., C. Hansson, H. Rorsman and E. Rosengren (1982) The effect of cysteine on oxidation of tyrosine, DOPA, and cysteinylDOPAs. Arch. Dermatol. Res., 272:103-115.
2. Andersson, H.C., L.D. Kohn, I. Bernardini, H.J. Blom, F. Tietze and W.A. Gahl (1990) Characterization of lysosomal monoiodotyrosine transport in rat thyroid cells. Evidence for transport by system h. J. Biol. Chem., 265:10950-10954.
3. Aroca, P., K. Urabe, T. Kobayashi, K. Tsukamoto and V.J. Hearing (1993) Melanin biosynthesis patterns following hormonal stimulation. J. Biol. Chem., 268:25650-25655.
4. Benathan, M. (1996) Modulation of 5-S-cysteinyldopa formation by tyrosinase activity and intracellular thiols in human melanoma cells. Melanoma Res., 6:183-189.
5. Benathan, M. and F. Labidi (1996) Cysteine-dependent 5-S-cysteinyldopa formation and its regulation by glutathione in normal epidermal melanocytes. Arch. Dermatol. Res., 288:697-702.
6. Benedetto, J.P., J.P. Ortonne, C. Voulot, C. Khatchadourian, G. Prota and J. Thivolet (1982) Role of thiol compounds in mammalian melanin pigmentation. II. Glutathione and related enzymatic activities. J. Invest. Dermatol., 79:422-424.
7. Bennett, D.C., P.J. Cooper and I.R. Hart (1987) A line of non-tumorigenic mouse melanocytes, syngeneic with the B16 melanoma and requiring a tumor promoter for growth. Int. J. Cancer, 39:414-418.
8. Bernar, J., F. Tietze, L.D. Kohn, I. Bernardini, G.S. Harper, E.F. Grollman and W.A. Gahl (1986) Characteristics of a lysosomal membrane transport system for tyrosine and other neutral amino acids in rat thyroid cells. J. Biol. Chem., 261:17107-17112.
9. Camakaris, J., D.M. Danks, L. Ackland, E. Cartwright, P. Borger and R.G.H. Cotton (1980) Altered copper metabolism in cultured cells from human Menkes' Syndrome and mottled mouse mutants. Biochem. Genet., 18:117-131.
10. Carstam, R., C. Edner, C. Hansson, C. Lindbladh, H. Rorsman and E. Rosengren (1986) Metabolism of 5-S-glutathionyl-DOPA. Acta Derm. Venereol., 126:1-12.
11. Chiu, E., M.L. Lamoreux and S.J. Orlow (1993) Postnatal ocular expression of tyrosinase and related proteins: disruption by the pink-eyed unstable (pun) mutation. Exp. Eye Res., 57:301-305.
12. Collarini, E.J., R.L. Pisoni and H.N. Christensen (1989) Characterization of a transport system for anionic amino acids in human fibroblast lysosomes. Biochim. Biophys. Acta, 987:139-144.
13. del-Marmol, V., S. Ito, B. Bouchard, A. Libert, K. Wakamatsu, G. Ghanem and F. Solano (1996) Cysteine deprivation promotes eumelanogenesis in human melanoma cells. J. Invest. Dermatol., 107:698-702.
14. Diment, S., M. Eidelman, G.M. Rodriguez and S.J. Orlow (1995) Lysosomal hydrolases are present in melanosomes and are elevated in melanizing cells. J. Biol. Chem., 270:4213-4215.
15. Gahl, W.A., N. Bashan, F. Tietze, I. Bernardini and J.D. Schulman (1982) Cystine transport is defective in isolated leukocyte lysosomes from patients with cystinosis. Science, 217:1263-1265.
16. Gahl, W.A., S.B. Potterf, D. Durham-Pierre, M.H. Brilliant and V.J. Hearing (1995) Melanosomal tyrosine transport in normal and pink-eyed dilution murine melanocytes. Pigment Cell Res., 8:229-233.
17. Harper, G.S., L.D. Kohn, I. Bernardini, J. Bernar, F. Tietze, H.C. Andersson and W.A. Gahl (1988) Thyrotropin stimulation of lysosomal tyrosine transport in rat FRTL-5 thyroid cells. J. Biol. Chem., 263:9320-9325.
18. Hearing, V.J. (1993) Unraveling the melanocyte. Am. J. Hum. Gen., 52:1-7.
19. Hearing, V.J. (1998) The regulation of melanin production. In: The Pigment Cell: Physiology and Pathophysiology. J.J. Nordlund, R.E. Boissy, V.J. Hearing, R.A. King, and J.P. Ortonne, eds. Oxford University Press, New York, pp. 423-438.
20. Hearing, V.J. and R.A. King (1993) Determinants of skin color: melanocytes and melanization. In: Pigmentation and Pigmentary Abnormalities. N. Levine, ed. CRC Press, New York, pp. 3-32.
21. Holstein, T.J., R.Q. Fung, W.C. Quevedo, Jr. and T.C. Bienieki (1979) Effect of altered copper metabolism induced by mottled alleles and diet on mouse tyrosinase. Proc. Soc. Exp. Biol. Med., 162:264-268.
22. Hunt, G., S. Kyne, S. Ito, K. Wakamatsu, C. Todd and A.J. Thody (1995) Eumelanin and phaeomelanin contents of human epidermis and cultured melanocytes. Pigment Cell Res., 8:202-208.
23. Ito, S. (1993) Biochemistry and physiology of melanin. In: Pigmentation and Pigmentary Disorders. N. Levine, ed. CRC Press, Boca Raton, FL, pp. 33-60.
24. Ito, S. and K. Fujita (1985) Microanalysis of eumelanin and pheomelanin in hair and melanomas by chemical degradation and liquid chromatography. Anal. Biochem, 144:527-536.
25. Ito, S., E. Novellino, F. Chioccara, G. Misuraca and G. Prota (1980) Co-polymerization of DOPA and cysteinylDOPA in melanogenesis in vitro. Experientia, 36:822-823.
26. Ito, S., A. Palumbo and G. Prota (1985) Tyrosinase-catalyzed conjugation of DOPA with glutathione. Experientia, 41:960-961.
27. Ito, S. and K. Wakamatsu (1994) An improved modification of permanganate oxidation of eumelanin that gives constant yield of pyrrole-2,3,5-tricarboxylic acid. Pigment Cell Res., 7:141-144.
28. Jiménez, M., F. García-Cánovas, F. García-Carmona, J.L. Iborra and J.A. Lozano (1986) Kinetics and stoichiometry of cysteinylDOPA formation in the first steps of melanogenesis. Int. J. Biochem., 18:161-166.
29. King, R.A., V.J. Hearing, and W.S. Oetting (1997) Abnormalities of pigmentation. In: Emery and Rimoin's Principles and Practice of Medical Genetics. D.L. Rimoin, J.M. Connor, and R.E. Pyeritz, eds. Churchill Livingstone, New York, pp. 1171-1203.
30. Kobayashi, T., K. Urabe, S.J. Orlow, K. Higashi, G. Imokawa, B.S. Kwon, S.B. Potterf and V.J. Hearing (1994) The pmel17/silver locus protein: characterization of its role in mammalian melanogenesis. J. Biol. Chem., 269:29198-29205.
31. Kobayashi, T., W.D. Vieira, S.B. Potterf, C. Sakai, G. Imokawa and V.J. Hearing (1995) Modulation of melanogenic protein expression during the switch from eu- to pheomelanogenesis. J. Cell. Sci., 108:2301-2309.
32. Napolitano, A., C. Costantini, O. Crescenzi and G. Prota (1994) Characterization of 1,4-benzothiazine intermediates in the oxidative conversion of 5-S-cysteinyldopa to pheomelanins. Tetrahedron Lett., 35:6365-6368.
33. Orlow, S.J. (1995) Melanosomes are specialized members of the lysosomal lineage of organelles. J. Invest. Dermatol., 105:3-7.
34. Pisoni, R.L., T.L. Acker, K.M. Lisowski, R.M. Lemons and J.G. Thoene (1990) A cysteine-specific lysosomal transport system provides a major route for the delivery of thiol to human fibroblast lysosomes: possible role in supporting lysosomal proteolysis. J. Cell Biol., 110:327-335.
35. Pisoni, R.L., K.S. Flickinger, J.G. Thoene and H.N. Christensen (1987a) Characterization of carrier-mediated transport systems for small neutral amino acids in human fibroblast lysosomes. J. Biol. Chem., 262:6010-6017.
36. Pisoni, R.L., J.G. Thoene and H.N. Christensen (1985) Detection and characterization of carrier-mediated cationic amino acid transport in lysosomes of normal and cystinotic human fibroblasts. Role in therapeutic cystine removal? J. Biol. Chem., 260:4791-4798.
37. Pisoni, R.L., J.G. Thoene, R.M. Lemons and H.N. Christensen (1987b) Important differences in cationic amino acid transport by lysosomal system c and y + of the human fibroblast. J. Biol. Chem., 262:15011-15018.
38. Potterf, S.B., M. Furumura, E.V. Sviderskaya, C. Santis, D.C. Bennett and V.J. Hearing (1998) Normal tyrosine transport and abnormal tyrosinase routing in pinkeyed-dilution melanocytes. Exp. Cell Res., 244:319-326.
39. Potterf, S.B., J. Muller, I. Bernardini, F. Tietze, T. Kobayashi, V.J. Hearing and W.A. Gahl (1996) Characterization of a melanosomal transport system in murine melanocytes mediating entry of the melanogenic substrate tyrosine. J. Biol. Chem., 271:4002-4008.
40. Prota, G. (1972) Structure and biogenesis of pheomelanins. In: Pigmentation: Its Genesis and Biologic Control. V. Riley, ed. Appleton-Century-Crofts, New York, pp. 615-630.
41. Prota, G. (1992) Melanins and Melanogenesis. Academic Press, New York, pp. 1-290.
42. Puri, N., and M.H. Brilliant (1998) The function of the pink-eyed dilution protein. Pigment Cell Res., 11:15 (Abstract).
43. Renlund, M., F. Tietze and W.A. Gahl (1986) Defective sialic acid egress from isolated fibroblast lysosomes of patients with Salla disease. Science, 232:759-762.
44. Riley, P.A. (1997) Melanin. Int. J. Biochem. Cell Biol., 29:1235-1239.
45. Rosemblat, S., D. Durham-Pierre, J.M. Gardner, Y. Nakatsu, M.H. Brilliant and S.J. Orlow (1994) Identification of a melanosomal membrane protein encoded by the pink-eyed dilution (type II oculocutaneous albinism) gene. Proc. Natl. Acad. Sci. U.S.A., 91:12071-12075.
46. Rosemblat, S., E.V. Sviderskaya, D.J. Easty, A. Wilson, B.S. Kwon, D.C. Bennett and S.J. Orlow (1998) Melanosomal defects in melanocytes from mice lacking expression of the pink-eyed dilution gene: correction by culture in the presence of excess tyrosine. Exp. Cell Res., 239:344-352.
47. Seiji, M., K. Shimao, M.S.C. Birbeck and T.B. Fitzpatrick (1963) Subcellular localization of melanin biosynthesis. Ann. N.Y. Acad. Sci., 100:497-533.
48. Smit, N.P., R.M. Kolb, E.G.W.M. Lentjes, K.C. Noz, H. van der Meulen, H.K. Koerten, B.J. Vermeer and S. Pavel (1998) Variations in melanin formation by cultured melanocytes from different skin types. Arch. Dermatol. Res., 290:342-349.
49. Spritz, R.A. and V.J. Hearing (1994) Genetic disorders of pigmentation. In: Advances in Human Genetics. K. Hirschhorn and H. Harris, eds. Plenum Press, New York, pp. 1-45.
50. Tietze, F., L.D. Kohn, A.D. Kohn, I. Bernardini, H.C. Andersson, M.D. Adamson, G.S. Harper and W.A. Gahl (1989a) Carrier-mediated transport of monoiodotyrosine out of thyroid cell lysosomes. J. Biol. Chem., 264:4762-4765.
51. Tietze, F., R. Seppala, M. Renlund, J.J. Hopwood, G.S. Harper, G.H. Thomas and W.A. Gahl (1989b) Defective lysosomal egress of free sialic acid (N-acetylneuraminic acid) in fibroblasts of patients with infantile free sialic acid storage disease. J. Biol. Chem., 264:15316-15322.
52. Urabe, K., P. Aroca and V.J. Hearing (1993) From gene to protein: determination of melanin synthesis. Pigment Cell Res., 6:186-192.
53. Wilbrandt, W. and T. Rosenburg (1961) The concept of carrier transport and its corollaries in pharmacology. Pharm. Rev., 13:109-183.
54. Winder, A.J., T. Kobayashi, K. Tsukamoto, K. Urabe, P. Aroca, K. Kameyama and V.J. Hearing (1994) The tyrosinase gene family: Interactions of melanogenic proteins to regulate melanogenesis. Cell. Mol. Biol. Res., 40:613-626.
55. Zhou, B.K., T. Kobayashi, P.D. Donatien, D.C. Bennett, V.J. Hearing and S.J. Orlow (1994) Identification of a melanoso mal matrix protein encoded by the murine (si) silver locus using 'organelle scanning. Proc. Natl. Acad. Sci. U.S.A., 91:7076-7080.