Antibacterial synergistic effect of chlorhexidine and hydrogen peroxide against Streptococcus sobrinus, Streptococcus faecalis and Staphylococcus aureus

Journal of Oral Rehabilitation

Volumn 26, Issue 2, 1999, Pages 151-156

  Steinberg, D ^a   Heling, I ^a   Daniel, I ^a   Ginsburg, I ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE; CHLORHEXIDINE GLUCONATE; DRUG DERIVATIVE; HYDROGEN PEROXIDE; OXIDIZING AGENT; TOPICAL ANTIINFECTIVE AGENT;

ARTICLE; CELL MEMBRANE; CELL ORGANELLE; DRUG COMBINATION; DRUG EFFECT; DRUG POTENTIATION; ENTEROCOCCUS FAECALIS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MICROBIOLOGY; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS SOBRINUS; TOOTH PLAQUE;

ANTI-INFECTIVE AGENTS, LOCAL; CELL MEMBRANE; CHLORHEXIDINE; DENTAL PLAQUE; DRUG COMBINATIONS; DRUG SYNERGISM; ENTEROCOCCUS FAECALIS; HUMANS; HYDROGEN PEROXIDE; ORGANELLES; OXIDANTS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS SOBRINUS;

EID: 0033072953     PISSN: 0305182X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2842.1999.00343.x     Document Type: Article

References (26)

1. ADDY, M. (1986) Chlorhexidine compared with other locally delivered antimicrobials. A short review. Journal of Clinical Periodontology, 13, 957.
2. ADDY, M. & LANGEROUDI, M. (1984) Comparison of the immediate effects on the sub-gingival microflora of acrylic strips containing 40% chlorhexidine, metronidazole or tetracycline. Journal of Clinical Periodontology, 11, 379.
3. AHMED, F.I.K. & RUSSELL, C. (1975) Synergism between ultrasonic waves and hydrogen peroxide in the killing of the micro-organisms. Journal of Applied Bacteriology, 39, 31.
4. BLOCK, B.B. (1991) Peroxygen compounds. In: Disinfection, Sterilization, and Presentation (ed. S.S. Block), 4th edn, 167. Lea & Febiger, Philadelphia, PA.
5. BONESVOLL, P. (1977) Oral pharmacology of chlorhexidine. Journal of Clinical Periodontology, 4, 49.
6. BROWN, A.T., LARGENT, B.A., FERRETTI, G.A. & LILLICH, T.T. (1986) Chemical control of plaque-dependent oral diseases: The use of chlorhexidine. Compendium of Continuing Education in Dentistry, 7, 719.
7. DENTON, G.W. (1991) Chlorhexidine. In: Disinfection, Sterilization, and Preservation (ed. S.S. Block), 4th edn, 274. Lea & Febiger, Philadelphia, PA.
8. DRAKE, D.R., GRIGSBY, W., CARDENZANA, A. & DUNKERSON, D. (1993) Synergistic, growth-inhibitory effects of chlorhexidine and copper combinations on Streptococcus mutans, Actinomyces viscosus, and Actinomyces naeslundii. Journal of Dental Research, 72, 524.
9. FARDAL, O. & TURNBULL, R.S. (1986) A review of the literature on use of chlorhexidine in dentistry. Journal of American Dental Association, 112, 863.
10. GIERTSEN, E., SCHEIE, A.A. & ROLLA, G. (1988) Inhibition of plaque formation and plaque acidogenicity by zinc and chlorhexidine combinations. Scandinavian Journal of Dental Research, 96, 541.
11. GINSBURG, I. & KOHEN, R. (1995) Cell damage in inflammation and infectious sites might involve a coordinated 'cross-talk' among oxidants, microbial haemolysins and ampiphiles, cationic proteins, phospholipases, fatty acids, proteinases and cytokines (an overview). Free Radical Research, 22, 489.
12. GINSBURG, I., MITRA, R.S., GIBBS, D.F., VARANI, J. & KOHEN, R. (1993) Killing of endothelial cells and release of arachidonic acid. Synergistic effects among hydrogen peroxide, membrane-damaging agents, cationic substances, and proteinases and their modulation by inhibitors. Inflammation, 17, 295.
13. GRYTTEN, J., SCHEIE, A.A. & GIERTSEN, E. (1988) Synergistic antibacterial effects of copper and hexetidine against Streptococcus sobrinus and Streptococcus sanguis. Acta Odontologica Scandinavica, 46, 181.
14. HANKS, C.T., FAT, J.C., WATAHA, J.C. & CORCORAN, J.F. (1993) Cytotoxicity and dentine permeability of carbamide peroxide and hydrogen peroxide vital bleaching materials, in vitro. Journal of Dental Research, 72, 931.
15. HELING, I., SOMMER, M., STEINBERG, D., FRIEDMAN, M. & SELA, M.N. (1992) Microbiological evaluation of the efficacy of chlorhexidine in solution and in sustained-release device for dentine sterilization. International Endodontic Journal, 25, 15.
16. LANG, N.P. & BRECX, M.C. (1986) Chlorhexidine digluconate - an agent for chemical plaque control and prevention of gingival inflammation. Journal of Periodontal Research, (Suppl., 74-89).
17. LANG, N.P. & RAMSEIER-GROSSMANN, K. (1981) Optimal dosage of chlorhexidine digluconate in chemical plaque control when applied by the oral irrigator. Journal of Clinical Penodontology, 8, 189.
18. LOE, H., SCHIOTT, C.R., GLAVIND, L. & KARRING, T. (1976) Two years oral use of chlorhexidine in man. General design and clinical effects. Journal of Periodontal Research, 11, 135.
19. MARSHALL, M.V., CANCRO, L.P. & FISCHMAN, S.L. (1995) Hydrogen peroxide: a review of its use in dentistry. Journal of Periodontology, 66, 786.
20. REES, T.D. & ORTH, C.F. (1986) Oral ulcerations with the use of hydrogen peroxide. Journal of Periodontology, 57, 689.
21. ROLLA, G. & MELSEN, B. (1975) On the mechanism of plaque inhibition by chlorhexidine. Journal of Dental Research (Special Issue B), 54, 57.
22. ROLLA, G., LOE, H. & SCHIOTT, C.R. (1970) The affinity of chlorhexidine for hydroxyapatite and salivary mucins. Journal of Periodontal Research, 5, 90.
23. SCHIOTT, C.R., BRINER, W.W. & LOE, H. (1976) Two year oral use of chlorhexidine in man. I. The effect on salivary bacterial flora. Journal of Periodontal Research, 11, 142.
24. SHANI, S., FRIEDMAN, S. & STEINBERG, D. (1996) Relation between surface activity and antibacterial activity of aminefluorides. International Journal of Pharmaceuticals, 131, 33.
25. STEINBERG, D., AMIT, V., BRAYER, L., SELA, M.N. & FRIEDMAN, M. (1991) The effect of sustained release varnish of chlorhexidine in plastic shells on salivary Streptococcus mutans. Clinical Preventive Dentistry, 13, 9.
26. WEITZMAN, S.A., WEITBERG, A.B., STOSSEL, T.P., SCHWARTZ, J. & SHKLAR, G. (1986) Effects of hydrogen peroxide on oral carcinogenesis in hamsters. Journal of Periodontology, 57, 685.