BIS-GMA-based resins in dentistry: Are they safe?

Journal of the American Dental Association

Volumn 130, Issue 2, 1999, Pages 201-209

  Söderholm, Karl Johan ^a   Mariotti, Angelo ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF DENTISTRY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; BISPHENOL A BIS(2 HYDROXYPROPYL) ETHER DIMETHACRYLATE; ESTROGEN; ESTROGEN RECEPTOR; FISSURE SEALANT; PHENOL DERIVATIVE; RESIN CEMENT; XENOBIOTIC AGENT;

ANIMAL; BREAST TUMOR; CELL CULTURE; CHEMISTRY; DENTAL SURGERY; DRUG EFFECT; DRUG POTENTIATION; FEMALE; HUMAN; MALE; METABOLISM; REVIEW; STRUCTURE ACTIVITY RELATION; UTERUS;

ANIMALS; BISPHENOL A-GLYCIDYL METHACRYLATE; BREAST NEOPLASMS; DENTAL RESTORATION, PERMANENT; ESTROGENS, NON-STEROIDAL; FEMALE; HUMANS; MALE; PHENOLS; PIT AND FISSURE SEALANTS; RECEPTORS, ESTROGEN; RESIN CEMENTS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; UTERUS; XENOBIOTICS;

EID: 0033070677     PISSN: 00028177     EISSN: None     Source Type: Journal    
DOI: 10.14219/jada.archive.1999.0169     Document Type: Article

References (56)

1. Schnebel E, inventor. Verfahren zur Herstellung von Zahnersatzteilen, insbesondere Füllungen, aus Polymerisation-skunstharzen. Dtsch Reichspatentamt Patentschr German patent 760351: 1940.
2. Czapp AE, Schnebel E, Goelz A, inventors. Verfaren zur Schnellpolymerisation von Gemischen aus monomeren and polymeren Vinylferbindungen. Dtsch Reichspatentamt Patentschr German patent 975072: 1941.
3. Caul HJ, Schoonover IC. Color stability of direct filling resins. JADA 1953;56:448-52.
4. Kramer IRH. The relationship between pain and changes in the dental pulp following the insertion of fillings. Br Dent J 1954;96:9-13.
5. Hedegård B. Cold-polymerizing resins: a clinical and histological study. Acta Odontol Scand 1995;13(suppl 17):1-126.
6. Knock FE, Glenn JF, inventors. Dental material and method. U.S. patent 2558139: 1951.
7. Rose EE, Lal J, Green R, Cornell J. Direct resin filling materials: coefficient of thermal expansion and water sorption of polymethyl methacrylate. J Dent Res 1955;34:589-96.
8. Bowen RL. Use of epoxy resins in restorative materials. J Dent Res 1956;35:360-9.
9. Bowen RL. Properties of a silica-reinforced polymer for dental restorations. JADA 1963;66:57-64.
10. Bowen RL, inventor. Method of preparing a monomer having phenoxy and methacrylate groups linked by hydroxy glycerol groups. U.S. patent 3179623. April 1965.
11. Cueto EI, Buonocore MG. Sealing of pits and fissures with an adhesive resin: its use in caries prevention. JADA 1967;75(1):121-8.
12. Jordan RE, Suzuki M, Gwinnett AJ, Hunter JK. Restoration of fractured and hypoplastic incisors by the acid etch resin technique: a three-year report. JADA 1977;95(4):795-803.
13. Zachrisson BZ. The acid etch technique in orthodontics: Clinical studies. In: Silverstone LM, Dogon IL, eds. Proceedings of an international symposium on . . . the acid etch technique. St. Paul, Minn.: North Central Pub. Co.; 1975:265-75.
14. Rochette AL. Attachment of a splint to enamel of lower anterior teeth. J Prosthet Dent 1973;30(4):418-23.
15. Bowen RL, Paffenbarger GC, Miullineaux AL. A laboratory and clinical comparison of silicate cements and a direct-filling resin: a progress report. J Prosthet Dent 1968;20(15):426-37.
16. Lambrechts P, Braem M, Vanherle G. Accomplishments and expectations with posterior composite resins. In: Vanherle G, Smith DC, eds. Posterior composite resin dental restorative materials. Utrecht: Peter Szulc Publishing Co.; 1985:521-40.
17. Olea N, Pulgar R, Perez P, et al. Estrogenicity of resin-based composites and sealants used in dentistry. Environ Health Perspect 1996;104(37):298-305.
18. Dodds EC, Lawson W. Synthetic estrogenic agents without the phenanthrene nucleus. Nature 1936;137:996.
19. Glenn JF. Comments of Dr. Bowen's presentation. J Dent Res 1979;58:1504-6.
20. Niinimaki A, Rosberg J, Saari S. Allergic stomatitis from acrylic compounds. Contact-Dermatitis 1983;9:148.
21. Niinimaki A, Rosberg J, Saari S. Traces of epoxy resin in acrylic dental filling materials (letter). Contact-Dermatitis 1983;9:532.
22. Krishnan AV, Stathis P, Permuth SF, J Tokes L, Feldman D. Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 1993;132:2279-86.
23. Weinstein RL, Kelch RP, Jenner MR, Kaplan SL, Grumbach MM. Secretion of unconjugated androgens and estrogens by the normal and abnormal human testis before and after human chorionic gonadotropin. J Clin Invest 1974;53:1-6.
24. Yen SS. The biology of menopause. J Reprod Med 1977;18:287-96.
25. Mariotti A. Sex steroid hormones and cell dynamics in the periodontium. Crit Rev Oral Biol Med 1994;5:27-53.
26. Ke FC, Ramirez VD. Binding of progesterone to nerve cell membranes of rat brain using progesterone conjugated to 125I-bovine serum albumin as a ligand. J Neurochem 1990;54(2):467-72.
27. Lan NC, Chen JS, Belelli D, Pritchett DB, Seeburg PH, Gee KW. A steroid recognition site is functionally coupled to an expressed GABA(A)-benzodiazepine receptor. Eur J Pharmacol 1990;188(6):403-6.
28. Blackmore PF, Beebe SJ, Danforth DR, Alexander N. Progesterone and 17-alpha hydroxyprogesterone: novel stimulators of calcium influx in human sperm. J Biol Chem 1990;265(3):1376-80.
29. Koenig H, Fan CC, Goldstone AD, Lu CY, Trout JJ. Polyamines mediate androgenic stimulation of calcium fluxes and membrane transport in rat heart myocytes. Circ Res 1989;64(3):415-26.
30. Mawhinney MG, Neubauer BL. Actions of estrogens in the male. Invest Urol 1979;16:409-20.
31. Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 1963;21:533-51.
32. Löe H. Periodontal changes in pregnancy. J Periodontol 1965;36:209-16.
33. Hugoson A. Gingivitis in pregnant women: a longitudinal clinical study. Odontol Revy 1971;22(1):65-84.
34. Arafat AH. Periodontal status during pregnancy. J Periodontol 1974;45:641-3.
35. Miyazaki H, Yamashita Y, Shirahama R, et al. Periodontal condition of pregnant women assessed by CPITN. J Clin Periodontol 1991;18:751-4.
36. Maier AW, Orban B. Gingivitis in pregnancy. Oral Surg Oral Med Oral Pathol 1949;2:334-73.
37. Daston GP, Gooch JW, Breslin WJ, et al. Environmental estrogens and reproductive health: a discussion of the human and environmental data. Reprod Toxicol 1997;11:465-81.
38. Benet LZ, Kroetz DL, Sheiner LB. Pharmacokinetics: the dynamics of drug absorption, distribution and elimination. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. Goodman & Gilman's the pharmacologic basis of therapeutics. 9th ed. New York: McGraw-Hill; 1996:3-28.
39. Ross EM. Pharmacodynamics: mechanisms of drug action and the relationship between drug concentration and effects. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. Goodman & Gilman's the pharmacologic basis of therapeutics. 9th ed. New York: McGraw-Hill; 1996:29-42.
40. Nies AS, Spielberg SP. Principles of therapeutics. In: Hardman JG, Limbird LE, Molinoff PB, Ruddon RW, Gilman AG, eds. Goodman & Gilman's the pharmacologic basis of therapeutics. 9th ed. New York: McGraw-Hill; 1996:43-62.
41. Mariotti A, Hefti A. Agents for the control of supragingival plaque. In: Craig CR, Stitzel R, eds. Modern pharmacology. 5th ed. Boston: Little, Brown; 1997:533-40.
42. Tong W, Perkins R, Xing L, Welsh WJ, Sheehan DM. QSAR models for binding of estrogenic compounds to estrogen receptor alpha and beta subtypes. Endocrinology 1997;138:4022-5.
43. Nathanson D, Lertpitayakun P, Lamkin MS, Edalatpour M, Chou LL. In vitro elution of leachable components from dental sealants. JADA 1997;128:1517-23.
44. Hamid A, Hume WR. A study of component release from resin pit and fissure sealants in vitro. Dent Mater 1997;13(2):98-102.
45. Müller H, Olsson S, Söderholm KJ. The effect of comonomer composition, silane heating, and filler type on aqueous TEGDMA teachability in model resin composites. Eur J Oral Sci 1997;105(4):362-8.
46. Zelles T, Purushotham KR, Macauley SP, Oxford GE, Humphreys-Beher MG. Saliva and growth factors: the fountain of youth resides in us all. J Dent Res 1995;74:1826-32.
47. Wilson DW, Walker RF, Griffiths K. Saliva as a medium for chronobiological studies: its particular potential in steroid endocrinology. Annali dell Istituto Superiore di Sanita 1993;29:607-11.
48. Ferguson DB. Steroid hormones in saliva. In: Ferguson DB, ed. Frontiers of oral physiology. Vol. 5. Basel: Karger; 1984:1-154.
49. Mariotti A, Söderholm K-J, Johnson S. The in vivo effects of bisGMA on murine uterine weight, nucleic acids and collagen. Eur J Oral Sci 1998;106:1022-7.
50. Climie IJ, Hutson DH, Stoydin G. Metabolism of the epoxy resin component 2,2-bis[4(2,3-epoxypropoxy)phenyl]propane, the diglycidyl ether of bisphenol A (DGEBPA) in the mouse. Part I. A comparison of the fate of a single dermal application and of a single oral dose of 14C-DGEBPA. Xenobiotica 1981;11(6):391-9.
51. Rueggeberg FA, Tamareselvy K, Ergle JW. Network conversion and teachability of bisGMA/TEGDMA copolymers (abstract 1374). J Dent Res 1995;74 (special issue):183.
52. Rueggeberg FA, Ergle JW, Söderholm K-JM. Solubility of dental resins in selected water-based systems (abstract 2175). J Dent Res 1996;75(special issue):289.
53. Gram TE. Drug absorption and distribution. In: Craig CR, Stitzel RE, eds. Modern pharmacology. 5th ed. Boston: Little, Brown; 1997:13-24.
54. Kamaris CA. Biocompatibility of four different dental materials [thesis]. Gainesville, Fla.: University of Florida; 1997.
55. Munksgaard EC, Freund M. Enzymatic hydrolysis of (di)methacrylates and their polymers. Scand J Dent Res 1990;98:261-7.
56. Ferracane JL. Elution of leachable components from composites. J Oral Rehab 1994;1:441-52.