NK1-receptor activation prevents hydrocarbon-induced lung injury in mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 276, Issue 2 20-2, 1999, Pages

  Robledo, Raymond F ^a   Witten, Mark L ^b  

^a UNIVERSITY OF VERMONT   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Inhalation; JP 8 jet fuel; Pulmonary toxicology; Tachykinin

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; ACROLEIN; HYDROCARBON; NEUROKININ 1 RECEPTOR; OZONE; PENTETATE TECHNETIUM TC 99M; SUBSTANCE P; SULFUR DIOXIDE; DRUG DERIVATIVE; JP8 AVIATION FUEL; SUBSTANCE P, SAR(9) MET(O2)(11); SUBSTANCE P, SAR(9)-MET(O2)(11)-;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; EPITHELIUM CELL; LUNG ALVEOLUS MACROPHAGE; LUNG FUNCTION; LUNG INJURY; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; AEROSOL; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CONGENIC STRAIN; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; LUNG; LUNG DISEASE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

AEROSOLS; ANIMALS; ANIMALS, CONGENIC; BRONCHOALVEOLAR LAVAGE FLUID; HYDROCARBONS; LUNG; LUNG DISEASES; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, NEUROKININ-1; SUBSTANCE P;

EID: 0033070343     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1999.276.2.l229     Document Type: Article

References (36)

1. Baron, J., and J. M. Voigt. Localization, distribution, and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within lung. Pharmacol. Ther. 47: 419-445, 1990.
2. Bonham, A. C., K. S. Kott, and J. P. Joad. Sidestream smoke exposure enhances rapidly adapting receptor responses to substance P in young guinea pigs. J. Appl. Physlol. 81: 1715-1722, 1996.
3. Castagliuolo, L, A. C. Keates, B. Qiu, C. P. Kelly, S. Nikulasson, S. E. Leeman, and C. Pothoulakis. Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats. Proc. Natl. Acad. Sci. USA 94: 4788-4793, 1997.
4. De Sanctis, G. T., E. M. App, J. K. Trask, B. I. De Sanctis, J. E. Remmers, F. H. Y. Green, S. F. P. Man, and M. King. Resorptive clearance and transepithelial potential difference in capsaicin-treated F344 rats. J. Appl. Physiol. 68: 1826-1832, 1990.
5. Ekstrom, J., B.-O. Nilsson, and E. Rosengren. Substance P and vasoactive intestinal peptide influence polyamine metabolism in salivary glands. Acta Physiol. Scand. 136: 427-433, 1989.
6. Guard, S., S. J. Boyle, K. W. Tang, K. J. Watling, A. T. McKnight, and G. N. Woodruff. The interaction of the NK1 receptor antagonist CP-96,345 with L-type calcium channels and its functional consequences. Br. J. Pharmacol. 110: 385-391, 1993.
7. Harris, D. T., D. Sakiestewa, R. F. Robledo, and M. L. Witten. Immunotoxicological effects of JP-8 jet fuel exposure. Toxicol. Ind. Health 13: 43-55, 1997.
8. Ichikawa, S., S. P. Sreedharan, R. L. Owen, and E. J. Goetz. Immunochemical localization of type I VIP receptor and NK-1-type substance P receptor in rat lung. Am. J. Physiol. 268 (Lung Cell. Mol. Physiol. 12): L584-L588, 1995.
9. Joos, G., R. Pauwels, and M. Van Straeten. Effect of inhaled substance P and neurokinin A on the airways of normal and asthmatic subjects. Thorax 42: 779-783, 1987.
10. Killingsworth, C. R., J. D. Paulauskis, and S. A. Shore. Substance P content and preprotachykinin gene-I mRNA expression in a rat model of chronic bronchitis. Am. J. Respir. Cell Mol. Biol. 14: 334-340, 1996.
11. Kim, J. S., V. McKinnis, K. Adams, and S. R. White. Proliferation and repair of guinea pig tracheal epithelium after neuropeptide depletion and injury in vivo. Am. J. Physiol. 273 (Lung Cell. Mol. Physiol. 17): L1235-L1241, 1997.
12. Kim, J. S., K. F. Rabe, H. Magnussen, J. M. Green, and S. R. White. Migration and proliferation of guinea pig and human airway epithelial cells in response to tachykinins. Am. J. Physiol. 269 (Lung Cell. Mol. Physiol. 13): L119-L126, 1995.
13. Levy, G. N., and W. W. Weber. 2-Aminofluorene-hepatic DNA adducts in congenic mouse lines differing in Ah responsiveness. Carcinogenesis 11: 1233-1235, 1990.
14. Lindberg, S. Reflex-induced acceleration of mucociliary activity in rabbit after exposure to cigarette smoke. Bull. Eur. Physiopathol. Respir. 22: 273-279, 1986.
15. Lundberg, J. M., T. Hokfelt, C. R. S. Martling, and C. Cuello. Substance P-immunoreactive sensory nerves in the lower respiratory tract of various mammals including man. Cell Tissue Res. 236: 251-261, 1984.
16. Murris-Epsin, M., E. Pinelli, B. Pipy, P. Leophonte, and A. Didier. Substance P and alveolar macrophages: effects on oxidative metabolism and eicosanoid production. Allergy 50: 334-339, 1995.
17. Nakanishi, S. Mammalian tachykinin receptors. Annu. Rev. Neurosci. 14: 123-136, 1991.
18. 1 receptors on human isolated small bronchi. Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L763-L767, 1996.
19. Otsuka, M., and K. Yoshioka. Neurotransmitter functions of mammalian tachykinins. Physiol. Rev. 73: 229-308, 1993.
20. Pfaff, J., K. Parton, R. C. Lantz, H. Chen, A. M. Hays, and M. L. Witten. Inhalation exposure to JP-8 jet fuel alters pulmonary function and substance P levels in Fischer 344 rats. J. Appl. Toxicol. 15: 249-256, 1995.
21. Pfaff, J. K., B. J. Tollinger, R. C. Lantz, H. Chen, A. M. Hays, and M. L. Witten. Neutral endopeptidase (NEP) and its role in pathological pulmonary change with inhalation exposure to JP-8 jet fuel. Toxicol. Ind. Health 12: 93-103, 1996.
22. Pinkerton, K. E., and J. D. Crapo. Morphometry of the alveolar region of the lung. In: Toxicology of Inhaled Materials, edited by H. P. Witschi and J. D. Brain. Berlin, Germany: Springer-Verlag, 1985, p. 259-285.
23. Rabovsky, J., D. J. Judy, and W. H. Pailes. In vitro effects of straight-chain alkanes (n-hexane through n-dodecane) on rat liver and lung cytochrome P-450. J. Toxicol. Environ. Health 18: 409-421, 1986.
24. Rangachari, P. K., and D. McWade. Effects of tachykinins on the electical activity of isolated canine tracheal epithelium: an exploratory study. Regul. Pept. 12: 9-19, 1985.
25. Robledo, R. F., and M. L. Witten. Acute pulmonary response to inhaled JP-8 jet fuel aerosol in mice. Inhal. Toxicol. 10: 531-553, 1998.
26. Rodarte, J. R., and K. Rehder. Dynamics of respiration. In: Handbook of Physiology: The Respiratory System. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. III, pt. 1, chapt. 10, p. 131-144.
27. Rogers, D. F., B. Aursudkij, and P. J. Barnes. Effects of tachykinins on mucus secretion in human brochi in vitro. Eur. J. Pharmacol. 174: 283-286, 1989.
28. Sakamoto, T., P. J. Barnes, and K. F. Chung. Effect of CP-96,345, a non-peptide NK-1 receptor antagonist, against substance P-, bradykinin-, and allergen-induced airway microvascular leakage and bronchoconstriction in the guinea pig. Eur. J. Pharmacol. 231: 31-38, 1993.
29. Scharf, S. M., and I. Prinsloo. Pulmonary mechanics in dogs given doses of kerosene intratracheally. Am. Rev. Respir. Dis. 126: 695-700, 1982.
30. Schlosser, R. J., J. M. Czaja, B. Yang, and T. V. McCaffrey. Signal transduction mechanisms in substance P-mediated ciliostimulation. Otolaryngol. Head Neck Surg. 113: 582-588, 1995.
31. 2+ concentration and inositol phosphate formation. J. Immunol. 141: 2118-2124, 1988.
32. Sterner-Kock, A., K. R. Vesely, M. Y. Stovall, E. Ste. Schelegle, J. F. Green, and D. M. Hyde. Neonatal capsaicin treatment increases the severity of ozone-induced lung injury. Am. J. Respir. Crit. Care Med. 153: 436-443, 1996.
33. Turner, C. R., R. B. Stow, S. D. Talerico, E. P. Christian, and J. C. Williams. Protective role for neuropeptides in acute pulmonary response to acrolein in guinea pigs. J. Appl. Physiol. 75: 2456-2465, 1993.
34. 3H]substance P binding, selectively inhibits the behavioral response to intrathecally administered N-methyl-D-aspartate, but not substance P, in the mouse. J. Pharmacol. Exp. Ther. 281: 1231-1237, 1997.
35. Yu, X.-Y., B. J. Undem, and E. W. Spannhake. Protective effect of substance P on permeability of airway epithelial cells in culture. Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L889-L895, 1996.
36. 1 receptor antagonist in guinea pig lung. Peptides 16: 867-872, 1995.