Genotoxicity and cytotoxicity of the epoxy resin-based root canal sealer AH plus

Journal of Endodontics

Volumn 25, Issue 2, 1999, Pages 109-113

  Leyhausen, Gabriele ^a   Heil, Jürgen ^b   Reifferscheid, Georg ^b   Waldmann, Petra ^b   Geurtsen, Werner ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AH PLUS; EPOXY RESIN; MUTAGENIC AGENT; ROOT CANAL FILLING MATERIAL;

ANIMAL; ARTICLE; BIVALVE; CELL CULTURE; CELL STRAIN 3T3; CYTOLOGY; DRUG EFFECT; FIBROBLAST; GENETICS; HELA CELL; HUMAN; MOUSE; MUTAGEN TESTING; PERIODONTAL LIGAMENT; SALMONELLA TYPHIMURIUM;

3T3 CELLS; ANIMALS; BIVALVIA; CELLS, CULTURED; EPOXY RESINS; FIBROBLASTS; HELA CELLS; HUMANS; MICE; MUTAGENICITY TESTS; MUTAGENS; PERIODONTAL LIGAMENT; ROOT CANAL FILLING MATERIALS; SALMONELLA TYPHIMURIUM;

EID: 0033069683     PISSN: 00992399     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0099-2399(99)80007-7     Document Type: Article

References (20)

1. Geurtsen W, Leyhausen G. Biological aspects of root canal filling materials - histocompatibility, cytotoxicity, and mutagenicity. Clin Oral Invest 1997;1:5-11.
2. Spangberg L, Langeland K. Biologic effects of dental materials. 1. Toxicity of root canal filling materials on HeLa cells in vitro. J Oral Surg 1973;35:402-14.
3. Tagger M, Tagger E. Periapical reactions to calcium hydroxide-containing sealers and AH26 in monkeys. Endod Dent Traumatol 1989;5:139-46.
4. Briseno BM, Willershausen B. Root canal sealer cytotoxicity on human gingival fibroblasts. 2. Silicone- and resin-based sealers. J Endodon 1991; 11:537-40.
5. Leinenbach F, Leyhausen G, Geurtsen W. Biocompatibility of root-canal filling materials in fibroblast cultures [Abstract]. J Dent Res 1993;72:306.
6. Schweikl H, Schmalz G, Stimmelmayr H, Bey B. Mutagenicity of AH26 in an in vitro mammalian cell mutation assay. J Endodon 1995;21:407-10.
7. Spangberg LS, Barbosa SV, Lavigne GD. AH26 releases formaldehyde. J Endodon 1993;19:596-8.
8. Stea SU, Savarino L, Ciapetti G, Cenni E, Stea ST, Trotta F, Morozzi G, Pizzoferrato A. Mutagenic potential of root canal sealers: evaluation through Ames testing. J Biomed Mater Res 1994;28:319-28.
9. Heil J, Reifferscheid G, Waldmann P, Leyhausen G, Geurtsen W. Genotoxicity of dental materials. Mutat Res 1996;368:181-94.
10. Reifferscheid G, Heil J, Oda Y, Zahn RK. A microplate-version of the SOS/umu-test for rapid detection of genotoxins and genotoxic potentials of environmental samples. Mutat Res 1991;252:215-22.
11. Reifferscheid G, Heil J. Validation of the SOS/umu test using test results of 486 chemicals and comparison with the Ames test and carcinogenicity data. Mutat Res 1996;369:129-45.
12. Deutsches Institut für Normung e.V.: DIN 38415-3 - Bestimmung des erbogutverändernden Potentials von Wasser mit dem umu-Test. Beuth-Verlag GmBH, Berlin, Germany, 1996.
13. International Organization for Standardization (ISO). "Water quality - determination of the genotoxicity of water and waste water using the umu-test." Committee draft. April 1996
14. Maron D, Ames B. Revised methods for the salmonella mutagenicity test. Mutat Res 1983;113:173-215.
15. Heil J, Reifferscheid G. Detection of mammalian carcinogens with an immunological DNA-synthesis inhibition test. Carcinogenesis 1992;13:2389-94.
16. Waldmann P, Pivcevic B, Müller WEG, Zahn RK, Kurelec B. Increased genotoxicity of acetylaminofluorene by modulators of multixenobiotic resistance mechanisms: studies with the fresh water clam Corbicula fluminea. Mutat Res 1995;342:113-23.
17. Lehmann F, Leyhausen G, Geurtsen W. Cytotoxic alterations in different fibroblast cultures caused by matrix monomers [Abstract]. J Dent Res 1993;72:219.
18. Leyhausen G, Geurtsen W. Sensitivity of various cultured human oral cells to dental materials [Abstract]. J Dent Res 1994;73:293.
19. Nakamura H, Sakakibara F, Matsumoto Y, Hirano S, Hayakawa H, Sakai K, Morris Y. Study on the cytotoxicity of root canal filling materials. J Endodon 1986;12:156-60.
20. Al-Nazhan S, Spangberg S. Morphological cell changes due to chemical toxicity of a dental material: an electron microscopical study on human periodontal ligament fibroblasts and L929 cells. J Endodon 1990;16:129-34.