Effects of ascorbic acid on selenium teratogenicity in cultured rat embryos

Toxicology Letters

Volumn 105, Issue 2, 1999, Pages 123-128

  Usami, Makoto ^a   Tabata, Hirobumi ^a   Ohno, Yasuo ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Ascorbic acid; Embryo culture; Sodium selenate; Sodium selenite; Teratogenicity

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; SELENATE; SELENITE; SELENIUM;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG COMPARISON; EMBRYO; EMBRYO CULTURE; EMBRYOTOXICITY; IN VITRO STUDY; NONHUMAN; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; RAT; TERATOGENICITY;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; PREGNANCY; RABBITS; RATS; RATS, WISTAR; SELENIUM;

EID: 0033067747     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00394-4     Document Type: Article

References (20)

1. Bertram J.S., Kolonel L.N., Meyskens F.L. Jr. Rationale and strategies for chemoprevention of cancer in humans. Cancer Res. 47:1987;3012-3031.
2. Birt D.F. Update on the effects of vitamins A, C, and E and selenium on carcinogenesis. Proc. Soc. Exp. Biol. Med. 183:1986;311-320.
3. Brown N.A., Fabro S. Quantitation of rat embryonic development in vitro: a morphological scoring system. Teratology. 24:1981;65-78.
4. DeYoung D.J., Bantle J.A., Fort D.J. Assessment of the developmental toxicity of ascorbic acid, sodium selenate, coumarin, serotonin, and 13-cis retinoic acid using FETAX. Drug Chem. Toxicol. 14:1991;127-141.
5. Faustman-Watts E.M., Namkung M.J., Juchau M.R. Modulation of the embryotoxicity in vitro of reactive metabolites of 2-acetylaminofluorene by reduced glutathione and ascorbate and via sulfation. Toxicol. Appl. Pharmacol. 86:1986;400-410.
6. Ferm V.H., Hanlon D.P., Willhite C.C., Choy W.N., Book S.A. Embryotoxicity and dose-response relationships of selenium in hamsters. Reprod. Toxicol. 4:1990;183-190.
7. Franke K.W., Moxon A.L., Poley W.E., Tully W.C. Monstrosities produced by the injection of selenium slats into hens' eggs. Anat. Rec. 65:1936;15-22.
8. Gad S.C., Weil C.S. Statistics for toxicologists. Hayes A.W. Principles and Methods of Toxicology. Second edition:1989;435-483 Raven Press, New York.
9. Heinz G.H., Hoffman D.J., Krynitsky A.J., Weller D.M.G. Reproduction in mallards fed selenium. Environ. Toxicol. Chem. 6:1987;423-433.
10. Hoffman D.J., Heinz G.H. Embryotoxic and teratogenic effects of selenium in the diet of mallards. J. Toxicol. Environ. Health. 24:1988;477-490.
11. Ip C. Interaction of vitamin C and selenium supplementation in the modification of mammary carcinogenesis in rats. J. Natl. Cancer Inst. 77:1986;299-301.
12. Novotny J.A., Milner J.A. Impact of ascorbic acid on selenium-induced growth inhibition of canine mammary tumor cells in vitro. J. Nutr. Biochem. 4:1993;341-345.
13. Overman D.O., Graham M.N., Roy W.A. Ascorbate inhibition of 6-aminonicotinamide teratogenesis in chick embryos. Teratology. 13:1976;85-94.
14. Palmer I.S., Arnold R.L., Carlson C.W. Toxicity of various selenium derivatives to chick embryos. Poultly Sci. 52:1973;1841-1846.
15. Ridgway L.P., Karnofsky D.A. The effects of metals on the chick embryo: toxicity and production of abnormalities in development. Ann. N.Y. Acad. Sci. 55:1952;203-215.
16. Tabata H., Usami M., Sakemi K., Kawashima K., Takanaka A. Effects of depletion of embryonic glutathione on selenium teratogenicity in cultured rat embryos. J. Toxicol. Sci. 18:1993;428.
17. Tarantal A.F., Willhite C.C., Lasley B.L., Murphy C.J., Miller C.J., Cukierski M.J., Book S.A., Hendrickx A.G. Developmental toxicity of L-selenomethionine in Macaca fascicularis. Fundam. Appl. Toxicol. 16:1991;147-160.
18. Usami M., Ohno Y. Teratogenic effects of selenium compounds on cultured postimplantation rat embryos. Teratogen Carcinogen. Mutagen. 16:1996;27-36.
19. Willhite, C.C., 1993. Selenium teratogenesis. Species-dependent response and influence on reproduction. In: Keen, C.L., Bendich, A., Willhite, C.C. (Eds.), Ann. NY Acad. Sci. Vol. 678, Maternal Nutrition and Pregnancy Outcome, New York Academy of Sciences, New York, pp. 169-177.
20. Yonemoto J., Sato H., Himeno S., Suzuki T. Toxic effects of sodium selenite on pregnant mice and modification of the effects by vitamin E or reduced glutathione. Teratology. 28:1983;333-340.