Inhibitory effects of indomethacin on interleukin-1 and nitric oxide production in rat microglia in vitro

International Journal of Immunopharmacology

Volumn 21, Issue 3, 1999, Pages 219-225

  Du, Ze Ying ^a   Li, Xiao Yu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Indoemthacin; Interleukin 1; Microglia; Nitric oxide; Tumor necrosis factor

Indexed keywords

AMYLOID; INDOMETACIN; INTERLEUKIN 1; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; TUMOR NECROSIS FACTOR ALPHA;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DRUG ACTIVITY; IN VITRO STUDY; MALE; MICROGLIA; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; THYMOCYTE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; INDOMETHACIN; INTERLEUKIN-1; MICE; MICE, INBRED BALB C; MICROGLIA; NITRIC OXIDE; NITRITES; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033067110     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0192-0561(98)00084-8     Document Type: Article

References (22)

1. Aisen, P. S., and Davis, K. L. (1994). Inflammatory mechanisms in Alzheimers disease: implications for therapy. Am J Psychiatry, 151, 1105-1113.
2. Amin, A. R., Vyas, P., Attur, M., Leszczynska-Piziak, J., Patel, I. R., Weissmann, G., and Abramson, S. B. (1996). A novel mechanism of action of aspirin-like drugs: effect on inducible nitric oxide synthsae. In P. Moncada, J. Stamler, S. Gross, and E. A. Higgs (Eds) The biology of nitric oxide Part 5 (p. 4).London: Portland Press.
3. Andersen, K., Launer, L. J., Ott, A., Hoes, A. W., Breteler, M. M. B., and Hofman, A. (1995) Do nonsteroidal antiinflammatory drugs decrease the risk for Alzheimers disease? Neurology, 45, 1441-1445.
4. Appel, K., Honegger, P., and Gebicke-Haerter, P. J. (1995). Expression of interleukin-3 and tumor necrosis factor-β mRNAs in cultured microglia. J Neuroimmunol, 60, 83-91.
5. Beard, C. M., Kokman, E., and Kurland, L. T. (1991). Rheumatoid artithritis and susceptibility to Alzheimers disease. Lancet, 337, 1426.
6. Breitner, J. C. S., Gau, B. A., Welsh, K. A., Plassman, B. L., McDonald, W. M., Helmas, H. J., and Anthony, J. C. (1994). Inverse association of anti-inflammatory treatments and Alzheimers disease. Neurology, 44, 227-232.
7. Breitner, J. C. S., Welsh, K. A., Helmas, H. J., Gaskell, P. C., Gau, B. A., Roses, A. D., Perieak-Vance, M. A., and Saunders, A. M. (1995). Delayed onset of Alzheimers disease with nonsteroidal anti-inflammatoryand histamine H2 blocking drugs. Neurobiol Aging, 16, 523-530.
8. Du, Z. Y. and Li, X. Y. (1998). Cytokine and nitric oxide production by rat microglia stimulated with lipopolysaccharides in vitro. Acta Pharmacol Sin, 19, 257-260.
9. Fagarasan, M. O., and Aisen, P. S. (1996). IL-1 and anti-inflammatory drugs modulate Aβ cytotoxicity in PC12 cells. Brain Res, 723, 231-234.
10. Flick, D. A., and Gifford, G. E. (1984) Comparison of in vitro cell cytotoxic assay for tumor necrosis factor. J Immunol Methods 68, 167-175.
11. Hayes, G. M., Woodroofe, M. N., and Cuzner, M. L. (1988). Characterization of microglia isolated from adult human and rat brain. J Neuroimmunol, 19, 177-189.
12. Hu, S., Peterson, P. K., and Chao, C. C. (1997). Cytokine-mediated neuronal apoptosis. Neuchem. Int, 30, 427-431.
13. Ignarro, L. J., Aeberhard, E. E., and Henderson, S. A.(1996). Nonsteriodal anti-inflammatory drugs prevent transcriptional expression of the inducible NO synthase gene in macrophages by interference with NF-κB activation. The Biology of nitric oxide Part 5. In P. Moncada, J. Stamler, S. Gross, and E. A. Higgs (Eds) The biology of nitric oxide Part 5 (p. 5). London: Portland Press.
14. Kondo, Y., Takano, F., and Hojo, H. (1993). Inhibitory effect of bisbenzylisoquinoline alkaloids on nitric oxide production in activated macrophages. Biochem Pharmacol, 46, 1887-1892.
15. Lucca, U., Tettamani, M., Forloni, G., and Spagnoli, A. (1994). Nonsteriodal antiinflammatory drug use in Alzheimers disease. Biol Psychiatry, 36, 854-856.
16. McGeer, P. L., McGeer, E. G., Rogers, J., and Sibley, J. (1990). Anti-inflammatory drugs and Alzheimers disease. Lancet, 335, 1037.
17. McGeer, P. L., and Rogers, J. (1992). Anti-inflammatory agents as a therapeutic approach to Alzheimers disease. Neurology, 42, 447-449.
18. McGeer, P. L., Rogers, J., and McGeer, E. G. (1994). Neuroimmune mechanisms in Alzheimers disease pathogenesis. Alzheimers Dis Assoc Dis, 8, 149-158.
19. Merrill, J. E. (1991). The effects of IL-1 and TNF-α on astrocytes, microglia, oligodendrocytes, and glial precussors in vitro. Dev Neurosci, 13, 130-134.
20. Rich, J. B., Rasmusson, D. X., Folstein, M. F., Carson, K. A., Kawas, C., and Brandt, J. (1995). Nonsteroidal anti-inflammatory drugs in Alzheimers disease. Neurology., 45, 51-55.
21. Rogers, J., Kirby, L. C., Hempleman, S. R., Berry, D. L., McGeer, P. L., Kaskniak, A. W., Zalinski, J. et al. (1993). Clinical trial of indomethacin in Alzheimers disease. Neurology, 43, 1609-1611.
22. Xiang, D. B., and Li, X. Y. (1993). Effects of Achyranthes bidentata polysaccharides on interleukin 1 and tumor necrosis factor -alpha production from mouse peritoneal macrophages. Acta Pharmacol Sin., 14, 332-336.