Effects of bromocriptine and haloperidol on prepulse inhibition: Comparison of the acoustic startle eyeblink response and the N1/P2 auditory-evoked response in man

Journal of Psychopharmacology

Volumn 13, Issue 1, 1999, Pages 3-9

  Abduljawad, K A J ^a   Langley, R W ^a   Bradshaw, C M ^a,b   Szabadi, E ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Acoustic startle response; Auditory evoked potential; Bromocriptine; D2 dopamine receptors; Eyeblink; Haloperidol; N1 P2 complex; Prepulse inhibition

Indexed keywords

BROMOCRIPTINE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; HALOPERIDOL; NEUROLEPTIC AGENT; PLACEBO; PROLACTIN;

ADULT; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; DOUBLE BLIND PROCEDURE; ELECTROMYOGRAPHY; EVOKED AUDITORY RESPONSE; EYELID REFLEX; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; ORBICULARIS OCULI MUSCLE; PREPULSE INHIBITION; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; PSYCHOPHARMACOLOGY; STARTLE REFLEX;

EID: 0033066986     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/026988119901300101     Document Type: Article

References (36)

1. Abduljawad K A J, Langley R W, Bradshaw C M, Szabadi E (1997) Effects of clonidine and diazepam on the acoustic startle response and on its inhibition by 'prepulses' in man. J Psychopharmac 11: 29-34
2. Abduljawad K A J, Langley R W, Bradshaw C M, Szabadi E (1998) Effects of bromocriptine and haloperidol on prepulse inhibition of the acoustic startle response in man. J Psychopharmac 12: 239-245
3. Adler L E, Pachtman E, Franks R D, Pecevich M, Waldo M C, Freedman R (1982) Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biol Psychiat 17: 639-654
4. Arya D K, Langley R W, Szabadi E, Bradshaw C M (1997) Comparison of the effects of high ambient temperature and clonidine on autonomic functions in man. Naunyn-Schmiedeberg's Arch Pharmac 335 :376-383
5. Bakshi V P, Geyer M A, Taaid N, Swerdlow N R (1995) A comparison of the effects of amphetamine, strychnine and caffeine on prepulse inhibition and latent inhibition. Behav Pharmac 6: 801-809
6. Bond A J, Lader M H (1974) The use of analogue scales in rating subjective feelings. Br J Med Psychol 47: 211-218
7. Braff D L, Stone C, Callaway E, Geyer M A, Glick I D, Bali L (1978) Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15: 339-343
8. Braff D L, Grillon C, Geyer M A (1992) Gating and habituation of the startle reflex in schizophrenic patients. Archs Gen Psychiat 49: 206-215
9. Campeau S, Davis M (1995) Prepulse inhibition of the acoustic startle using visual and auditory prepulses: disruption by apomorphine. Psychopharmacology 117: 267-274
10. Davis M (1980) Neurochemical modulation of sensory-motor reactivity: acoustic and tactile startle reflexes. Neurosci Biobehav Rev 4: 791-805
11. Davis M, Gendelman D S, Tischler M D, Gendelman P M (1982) A primary acoustic startle circuit: lesion and stimulation studies. J Neurosci 6: 791-805
12. Dawson M E, Hazlett E A, Filion D L, Neuechterlein K H, Schell A M (1993) Attention and schizophrenia: impaired modulation of the startle reflex. J Abnorm Psychol 102: 633-641
13. Grillon C, Ameli R, Charney D S, Krystal A, Braff D L (1992) Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biol Psychiat 32: 939-943
14. Howell D C (1997) Statistical methods in psychology, 4th edn. Duxbury, Belmont, CA
15. Javaid (1994) Clinical pharmacokinetics of antipsychotics. J Clin Pharmac 34: 286-295
16. Judd L L, McAdams L, Budnick B, Braff D L (1992) Sensory gating deficits in schizophrenia: new results. Am J Psychiat 149: 488-493
17. Kumari V, Cotter P, Corr P J, Gray J A, Checkley S A (1996) Effect of clonidine on the human acoustic startle reflex. Psychopharmacology 132: 352-360
18. Kuret J A, Murad F (1990) Adenohypophyseal hormones and related substances. In Goodman Gilman A, Rall T W, Nies A S, Taylor P (eds), The pharmacological basis of therapeutics, 8th edn. Pergamon Press, New York.
19. Mansbach R S, Geyer M A, Braff B L (1988) Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology 94: 507-514
20. Mauguiere F, Cooper R, Holder G E, Luxon L M, Murray N M F (1995) Evoked potentials: normal findings by modality. In Osselton J W (ed.), Clinical neurophysiology. Butterworth-Heinemann, Oxford
21. McDowd J M, Filion D L, Harris M J, Braff D L (1993) Sensory gating and inhibitory function in late-life schizophrenia. Schizophr Bull 19: 733-746
22. Meltzer H Y (1989) Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology 99: S18-S27
23. Nagamoto H T, Adler L E, Waldo M C, Griffith J, Freedman R (1991) Gating of auditory response in schizophrenics and normal controls: effects of recording site and stimulation interval on the P50 wave. Schizophr Res 4: 31-40
24. Nagamoto H T, Adler L E, Hea R A, Griffith J M, McRae K A, Freedman R (1996) Gating of auditory P50 in schizophrenia: unique effects of clozapine. Biol Psychiat 40: 181-188
25. Norris H (1971) The action of sedatives on brain-stem oculomotor systems in man. Neuropharmacology 10: 181-191
26. Peck R E (1959) The SHP test - an aid in the detection and measurement of depression. Archs Gen Psychiat 1: 35-40
27. 2 dopamine receptor agonist disrupts sensorimotor gating in rats. Neuropsychopharmacology 3: 211-218
28. Schall U, Schon A, Zerbin D, Eggers C, Oades R D (1996) Event-related potentials during an auditory discrimination with prepulse inhibition in patients with schizophrenia, obsessive-compulsive disorder and healthy subjects. Int J Neurosci 84: 15-33
29. Schwarzkopf S B, Lanberti J S, Smith D A (1993) Concurrent assessment of acoustic startle and auditory P50 evoked potential measures of sensory inhibition. Biol Psychiat 33: 815-828
30. Swerdlow N R, Braff D L, Geyer M A, Koob G F (1986) Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenia. Biol Psychiat 21: 23-33
31. Swerdlow N R, Mansbach R S, Geyer M A, Pulvirenti L, Braff D L (1990) Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine. Psychopharmacology 100: 530-536
32. Swerdlow N R, Caine S B, Braff D L, Geyer M A (1992) The neural substrates on sensorimotor gating of the startle reflex: a review. J Psychopharmac 6: 176-190
33. Swerdlow N R, Fillon D, Geyer M A, Braff D L (1995) 'Normal' personality correlates of sensorimotor, cognitive, and visuo-spatial gating. Biol Psychiat 37: 286-299
34. Varty G B, Higgins G A (1995) Examination of drug-induced and isolation-induced disruption of prepulse inhibition as models to screen antipsychotic drugs. Psychopharmacology 122: 15-26
35. Wachtel H (1991) Antiparkinsonian dopamine agonists: a review of the pharmacokinetics and neuropharmacology in animals and man. J Neural Transm (P-D Sect) 3: 151-201
36. Young D A, Waldo M, Rutledge J H, Freedman R (1990) Heriditability of inhibitory gating of the P5O auditory-evoked potential in monozygotic and dizygotic twins. Neuropsychobiology 33: 113-117