A clearance model of inhaled man-made fibers in rat lungs

Industrial Health

Volumn 37, Issue 1, 1999, Pages 103-107

  Hori, Hajime ^a   Ishimatsu, Sumiyo ^a   Oyabu, Takako ^b   Yamato, Hiroshi ^b   Morimoto, Yasuo ^b   Tsuda, Tohru ^b   Higashi, Toshiaki ^b   Tanaka, Isamu ^b  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Biopersistence; Ceramic fiber; Clearance model; Disintegration; Dissolution; Glass fiber; Potassium octatitanate whisker; Translocation

Indexed keywords

GLASS FIBER; POTASSIUM DERIVATIVE; TITANATE POTASSIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CERAMICS; CONTROLLED STUDY; FIBER; INHALATION; LUNG CLEARANCE; MACROPHAGE; MALE; MODEL; NONHUMAN; RAT;

ANIMALIA;

EID: 0033066981     PISSN: 00198366     EISSN: None     Source Type: Journal    
DOI: 10.2486/indhealth.37.103     Document Type: Article

References (7)

1. Eastes W, Hadley G (1995) Dissolution of fibres inhaled by rats. Inhalation Toxicology 7, 179-96.
2. Morgan A, Holmes A, Davison W (1982) Clearance of sized glass fibres from the rat lung and their solubility in vivo. Ann Occup Hyg 25, 317-31.
3. Yu CP, Ding YJ, Zhang L, Oberdorster G, Mast RW, Maxim LD, Utell MJ (1997) Retention modeling of refractory ceramic fibers (RCF) in humans. Regul Toxicol Pharmacol 25, 18-25.
4. Yamato H, Hori H, Tanaka I, Higashi T, Morimoto Y, Kido M (1994) Retention and clearance of inhaled ceramic fibres in rat lungs and development of a dissolution model. Occup Environ Med 51, 275-80.
5. Morris KJ, Launder KA, Morgan A, Hornby SB, Collier CG (1995) Preliminary data from investigations of the in vivo biopersistence of three experimental glass fibers of varying chemical composition. Exp Toxic Pathol 47, 179-82.
6. Searl A (1997) A comparative study of the clearance of respirable para-aramid, chrysotile and glass fibres from rat lungs. Ann Occup Hyg 41, 217-33.
7. Shutou T, Ishimatsu S, Hyakudo T, Hori H, Tanaka I, Fujino A, Higashi T (1992) Solubility of man-made fibers. Jpn J Ind Health 34, 883 (in Japanese).