Apoptosis and p53 gene expression in male reproductive tissues of cadmium exposed rats

BioMetals

Volumn 12, Issue 2, 1999, Pages 131-139

  Xu, Guogang ^a,b   Zhou, Guangqian ^a   Jin, Taiyai ^a,b   Zhou, Tong ^a,b   Hammarström, Sten ^a   Bergh, Anders ^a   Nordberg, Gunnar ^c  

^a UMEÅ UNIVERSITY   (Sweden)

^b FUDAN UNIVERSITY   (China)

^c NONE

Author keywords

Apoptosis; Cadmium; p53 gene expression; Rat; RT PCR; Testes

Indexed keywords

CADMIUM; PROTEIN BCL X; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; MALE; NONHUMAN; PROSTATE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; CADMIUM; GENE EXPRESSION; GENES, P53; MALE; METALLOTHIONEIN; PROSTATE; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; TESTIS;

EID: 0033066279     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1009273711068     Document Type: Article

References (35)

1. Abel, J., Ruiter, N. and Kuhn-Velten, W.N. 1991 Comparative study on metallothioncin induction in whole testicular tissue and isolated Leydig cells. Arch. Toxicol. 65, 228-234.
2. Azzouzi, A.E., Tsangaris, G. T., Pellegrini, O., Manuel, Y., Benveniste, J. and Thomas, Y. 1994 Cadmium induces apoptosis in a human T cell line. Toxicology 88, 127-139.
3. Boise, L.H., Gonzalez-Garcia, M., Postema, C.E., et al. 1993 bcl-x, a bcl-2-related gene that function as a dominant regulator of apoptotic cell death. Cell 74, 597-608.
4. Clarke, A.R., Purdie, C.A., Harrison, D.J., et al. 1993 Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852.
5. De, K.S., Enders, G.C. and Andrews, G.K. 1991 High levels of metallothionein messenger RNAs in male germ cells of adult mouse. Mol. Endocrinol. 5, 628-635.
6. Ghatak, S., Oliveria, P., Kaula, P. and Ho S-mei. 1996 Expression and regulation of metallothionein mRNA levels in the prostates of Nobel rats: Lack of expression in the ventral prostate and regulation by sex hormones in the dorsolateral prostate. Prostate 29, 91-100.
7. Gunn, S.A. Gould, T.C. and Anderson, W.A.D. 1963 Cadmium induced interstitial cell tumors in rats and mice and their prevention by zinc. J. Natl. Cancer Inst. 31, 745-752
8. Gunn, S.A. and Gould, T.C. 1970 Cadmium and Other Mineral Elements. In: A.D. Johnson, W.R. Gomes and N.L. Vandemark (eds), The Thesis. Academic Press, New York. pp. 377-481.
9. Hollstein, M., Sidransky, D., Vogeistein, B., and Harris, C.C. 1991 p53 mutations in human cancers. Science 253, 49-53.
10. Kuerbitz, S.J., Plunkett, B.S., Walsh, W.B. and Kastan, M.B. 1992 Wild-type p53 is a cell cycle checkpoint determination following irradiation. Proc. Natl. Acad. Sci. USA 89, 7491-7495.
11. Lane, D.P. (1992) p53, Guardian of the genome. Nature 358, 15-16.
12. Livingstone, L.R., White, A., Sprouse, J., Livanos, E., Jacks, T., and Tisty, T.D. 1992 Altered cell cycle arrest and gene amplification potential accompany loss of wild type p53. Cell 70, 923-935.
13. Lowe, S.W., Schmitt, E.M., Osborne, B.A., and Jacks, T. 1993 p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.
14. Mckenna, I.M., Bare, R.M. and Waalkes, M.P. 1996 Metallothionein gene expression in testicular interstitial cells and liver of rats treated with cadmium. Toxicology 107, 121-130.
15. Nolan, C.V. and Shaikh, Z.A. 1986 An evaluation of tissue metallothionein and genetic resistance to cadmium toxicity in mice. Toxicol. Appl. Pharmacol. 85, 135-144.
16. Nordberg, G.F. 1971 Effects of acute and chronic cadmium exposure on the testicle of mice. Environ. Physiol. 1, 171-187.
17. Nordberg, G.F. 1972 Cadmium metabolism and toxicity: Experimental studies on mice with special reference to the use of biological materials as indices of retention and the possible role of metallothionein in transport and detoxification of cadmium. Environ. Physiol. Biochem. 2, 7-36.
18. Parizek, J. 1957 The destructive effect of cadmium ion on testicular tissue and its prevention by zinc. J. Endocrinol. 15, 56-63.
19. Sambrook, J., Fritsch, E. F. and Maniatis, T. 1989 Analysis and cloning of eukaryotic genomic DNA: Isolation of DNA from mammalian cells. In: Molecular Cloning, 2nd Edn., Cold Spring Harbor Laboratory Press, New York, pp 9.14-9.19.
20. Shankland, S.J. and Scholey, J.W. 1994 Expression of transforming growth factor-β1 during diabetic renal hypertrophy. Kidney Int. 46, 430-442.
21. Shaw, P., Bovey, R., Tardy, S., Sshli, R., Sordat, B., and Costa, J. 1992 Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA 89, 4495-4499.
22. Shiraishi, N., Uno, H., and Waalkes. M.P. 1993a Effect of L-ascorbic acid pretreatment on cadmium toxicity in the male Fisher (F344/NCr) rat. Toxicology 85, 85-100.
23. Shiraishi, N., Barter, R., Uno, H., and Waalkes, M.P. 1993b Effect of progesterone pretreatment on cadmium toxicity in the male Fisher (F344/NCr) rat. Toxicol. Appl. Pharmacol. 118, 113-118.
24. Shiraishi, N. and Waalkes, M.P. 1994 Enhancement of metallothioncin gene expression in male Wistar (WF/NCr) rats by treatment with calmodulin inhibitors: Potential role of calcium regulatory pathway in metallothioncin induction. Toxic. Appl. Pharmacol. 125, 97-103.
25. Strasser, A., Harris, A.W., Jacks, T. and Cory, S. 1994 DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by bcl-2. Cell 79, 329-339.
26. Schwarts D., Goldfinger N., and Rotter V. 1993 Expression of p53 protein in spermatogenesis is confined to the tetraploid pachytene primary spermatocytes. Oncogene 8, 1487-1494.
27. Symonds, H., Krall., L., Remington, L., et al. 1994 p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78, 703-711.
28. Waalkes, M.P., Rehm, S., Riggs, C.W., et al. 1988 Cadmium carcinogenesis in male Wistar [Crl:(WI)BR] rats: Dose-response analysis of tumor induction in the prostate and testes and at the injection site. Cancer Res. 48, 4656-4663.
29. Waalkes, M.P., Coogan, T.P., and Barter, R.A. 1992 Toxicological principles in metal carcinogenesis with special emphasis on cadmium. Crit. Rev. Toxicol. 22, 175-201
30. Waalkes, M.P. and Rehm, S. 1994 Cadmium and prostatic cancer. J. Toxicol. Environ. Health 43, 251-259
31. Westin P, Brändström A, Damber JE and Bergh A. 1995 Castration plus oestrogen treatment induces but castration alone suppresses epithelial cell apoptosis in an androgen-sensitive rat prostatic adenocarcinoma. Br. J. Cancer 72, 140-145
32. Will K., Warnecke, G., Bergmann, S. and Deppert, Wolf G. 1995 Species- and tissue-specific expression of the C-terminal alternatively spliced form of the tumor suppressor p53. Nucleic Acids Res. 23, 4023-4028.
33. Xu, C., Johnson, J.E., Singh, P.K., Jones, M.M., Yan, H. and Carter, C.E. 1996 In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent. Toxicology 107, 1-8.
34. Yin, Y., Tainsky, M.A., Bischoff, F.Z., Strong, L.C., and Wahl, G.M. 1992 Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutation alleles. Cell 70, 937-948.
35. Yonish-Rouach, E., Resnitsky, D., Lolem, J., Sachs, L., Kimchi, A., and Oren, M. 1991 Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352, 345-347.