Synthesis and biological evaluation of 1,2,3,4-tetrahydroisoquinoline derivatives as potent and selective M2 muscarinic receptor antagonists

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 5, 1999, Pages 672-677

  Watanabe, Toshihiro ^a   Kinoyama, Isao ^a   Takizawa, Kenji ^a   Hirano, Seiko ^a   Shibanuma, Tadao ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

1,2,3,4 tetrahydroisoquinoline derivative; Antagonism; Bradycardia; M2 muscarinic receptor; M2 selectivity

Indexed keywords

1 DIETHYLAMINOMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE; 11 [[1 (DIETHYLAMINOMETHYL) 1,2,3,4 TETRAHYDRO 2 ISOQUINOLYL]ACETYL] 5,11 DIHYDRO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPIN 6 ONE; 11 [[2 (DIETHYLAMINOMETHYL) 1 INDOLINYL]ACETYL] 5,11 DIHYDRO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPIN 6 ONE; 11 [[2 (DIETHYLAMINOMETHYL) 1,2,3,4 TETRAHYDRO 2 QUINOLYL]ACETYL] 5,11 DIHYDRO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPIN 6 ONE; 11 [[3 (DIETHYLAMINOMETHYL) 1,2,3,4 TETRAHYDRO 2 ISOQUINOLYL]ACETYL] 5,11 DIHYDRO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPIN 6 ONE; 11 [[5 [(2 DIETHYLAMINO)ETHOXY] 1,2,3,4 TETRAHYDRO 2 ISOQUINOLYL]ACETYL] 5,11 DIHYDRO 6H PYRIDO[2,3 B][1,4]BENZODIAZEPIN 6 ONE; 2 DIETHYLAMINOMETHYL 1,2,3,4 TETRAHYDROQUINOLINE; 2 TERT BUTOXYCARBONYL 5 HYDROXY 1,2,3,4 TETRAHYDROISOQUINOLINE; 3 DIETHYLAMINOMETHYL 1,2,3,4 TETRAHYDROISOQUINOLINE (2 DIETHYLAMINOMETHYL)INDOLINE; 5 [(7 DIETHYLAMINO)HEPTYLOXY] 1,2,3,4 TETRAHYDROISOQUINOLINE; ISOQUINOLINE 1 CARBOXYLIC ACID DIETHYLAMIDE; MUSCARINIC M2 RECEPTOR ANTAGONIST; QUINOLINE 2 CARBOXYLIC ACID DIETHYLAMIDE; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; MALE; NONHUMAN; RAT; REACTION ANALYSIS; RECEPTOR AFFINITY; RECEPTOR OCCUPANCY; STRUCTURE ACTIVITY RELATION;

EID: 0033065799     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.672     Document Type: Article

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