The sensitivity of the lactulose/rhamnose gut permeability test

European Journal of Clinical Investigation

Volumn 29, Issue 2, 1999, Pages 160-165

  Van Nieuwenhoven, M A ^a   Geerling, B J ^a   Deutz, N E P ^a   Brouns, F ^b   Brummer, R J M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b Novartis Nutrition Research Unit   (Netherlands)

Author keywords

Chenodiol; Intestinal permeability; Lactulose rhamnose ratio; Sensitivity

Indexed keywords

CHENODEOXYCHOLIC ACID; LACTULOSE; RHAMNOSE;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INTESTINE MUCOSA PERMEABILITY; ISOMER; MALE; NORMAL HUMAN; PRIORITY JOURNAL; STATISTICAL ANALYSIS; URINE LEVEL;

ADOLESCENT; ADULT; CHENODEOXYCHOLIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INTESTINAL ABSORPTION; LACTULOSE; MALE; METHODS; PERMEABILITY; RHAMNOSE; SENSITIVITY AND SPECIFICITY;

EID: 0033065492     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1999.00421.x     Document Type: Article

References (63)

1. 1 Bjarnason I, MacPherson A, Hollander D. Intestinal permeability, an overview. Gastroenterology 1995; 108: 1566-81.
2. 2 Hollander D. The intestinal permeability barrier. Scand J Gastroenterol 1992; 27: 721-6.
3. 3 Travis S, Menzies I. Intestinal permeability: functional assessment and significance. Clin Sci 1992; 82: 471-88.
4. 4 Bjarnason I, Maxton D, Reynolds AP, Catt S, Peters TJ, Menzies IS. Comparison of 4 markers of intestinal permeability in control subjects and patients with coeliac disease. Scand J Gastroenterol 1994; 28: 630-9.
5. 5 Stenhammar L, Faith Magnusson K, Jansson G, Magnusson KE, Sundqvist TJ. Intestinal permeability to inert sugars and different, sized polyethyleneglycols in children with celiac disease. Pediatr Gastroenterol Nutr 1989; 9: 281-9.
6. 6 Stenhammar L, Stromberg S. Intestinal permeability to lactulose/L-rhamnose in children with celiac disease and other gastrointestinal disorders. Pediatr Gastroenterol Nutr 1988; 7: 304-6.
7. 7 Teahon K, Smethurst P, Levi AJ, Menzies IS, Bjarnason I. Intestinal permeability in patients with Crohn's disease and their first degree relatives. Gut 1992; 33: 320-3.
8. 8 Howden CW, Gillanders I, Morris AJ, Duncan A, Danesh B, Russell RI. Comparison of different measurements of intestinal permeability in inflammatory bowel disease. Am J Gastroenterol 1991; 86: 1445-9.
9. 9 Katz KD, Hollander D, Vadheim CM, et al. Intestinal permeability in patients with Crohn's disease and their healthy relatives. Gastroenterology 1989; 97: 927-31.
10. 10 Munkholm P, Langholz E, Hollander D, et al. Intestinal permeability in patients with Crohn's disease and ulcerative colitis and their first degree relatives. Gut 1994; 35: 68-72.
11. 11 Pignata C, Budillon G, Monaco G, et al. Jejunal bacterial overgrowth and intestinal permeability in children with immunodeficiency syndromes. Gut 1990; 31: 879-82.
12. 12 Lim SG, Menzies IS, Lee CA, Johnson MA, Pounder RE. Intestinal permeability and function in patients infected with human immunodefficiency virus. A comparison with coeliac disease. Scand J Gastroenterol 1993; 28: 573-80.
13. 13 Keating J, Bjarnason I, Somasundaram S, et al. Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea. Gut 1995; 37: 623-9.
14. 14 Morris AJ, Howden CW, Robertson C, et al. Increased intestinal permeability in ankylosing spondylitis; primary lesion or drug effect? Gut 1991; 32: 1470-2.
15. 15 Leclercq-Foucart J, Forget PP, Van Cutsem JL. Lactulose, rhamnose intestinal permeability in children with cystic fibrosis. J Pediatr Gastroenterol Nutr 1987; 6: 66-70.
16. 16 Penny DJ, Ingall CB, Boulton P, Walker-Smith JA, Basheer SM. Intestinal malabsorption in cystic fibrosis. Arch Dis Child 1986; 61: 1127-8.
17. 17 Berant M, Khourie M, Menzies IS. Effect of iron deficiency on small intestinal permeability in infants and young children. J Pediatr Gastroenterol Nutr 1992; 14: 17-20.
18. 18 Caffarelli C, Cavagni G, Menzies IS, Bertolini P, Atherton DJ. Elimination diet and intestinal permeability in atopic eczema: a preliminary study. Clin Exp Allergy 1993; 23: 28-31.
19. 19 Pike MG, Heddle RJ, Boulton P, Turner MW, Atherton DJ. Increased intestinal permeability in atopic eczema. J Invest Dermatol 1986; 86: 101-4.
20. 20 Ohri SK, Somasundaram S, Koak Y, et al. Cardiopulmonary bypass impairs small intestinal transport and increases gut permeability. Ann Thorac Surg 1993; 55: 1080-6.
21. 21 Ohri SK, Somasundaram S, Koak Y, et al. The effect of intestinal hypoperfusion on intestinal absorption and permeability during cardiopulmonary bypass. Gastroenterology 1994; 106: 318-23.
22. 22 Sinclair DG, Houldsworth PE, Keogh B, Pepper J, Evans TW. Gastrointestinal permeability following cardiopulmonary bypass: a randomised study comparing the effects of dopamine and dopexamine. Intensive Care Med 1997; 23: 510-6.
23. 23 Brewster DR, Manary MJ, Menzies IS, Henry RL, O'Loughlin EV. Comparison of milk and maize based diets in kwashiorkor. Arch Dis Child 1997; 76: 242-8.
24. 24 Brewster DR, Manary MJ, Menzies IS, O'Loughlin EV, Henry RL. Intestinal permeability in kwashiorkor. Arch Dis Child 1997; 76: 236-41.
25. 25 Jenkins AP, Menzies IS, Nukajam WS, Creamer B. The effect of ingested lactulose on absorption of L-rhamnose, D-xylose, and 3-O-methyl-D-glucose in subjects with ileostomies. Scand J Gastroenterol 1994; 29: 820-5.
26. 26 Parrilli G, Cuomo R, Nardone G, Maio G, Izzo CM, Budillon G. Investigation of intestine function during acute viral hepatitis using combined sugar oral loads. Gut 1987; 28: 1439-44.
27. 27 Noone C, Menzies IS, Banatvala JE, Scopes JW. Intestinal permeability and lactose hydrolysis in human rotaviral gastroenteritis assessed simultaneously by non-invasive differential sugar permeation. Eur J Clin Invest 1986; 16: 217-25.
28. 28 Mooradian AD, Morley JE, Levine AS, Prigge WF, Gebhard, RL. Abnormal intestinal permeability to sugars in diabetes mellitus. Diabetologia 1986; 29: 221-4.
29. 29 Du-Mont GC, Beach RC, Menzies IS. Gastrointestinal permeability in food, allergic eczematous children. Clin Allergy 1984; 14: 55-9.
30. 30 Bjarnason I. Intestinal permeability. Gut 1994; 35 (1 Suppl.): S18-S22.
31. 31 Bjarnason I, Williams P, So A, Zanelli G, Lev AJ, Gumpel MJ. Intestinal inflammation and permeability in rheumatoid arthritis, effects of non-steroidal anti-inflammatory drug. Lancet 1984; ii: 1171-4.
32. 32 Bjarnason I, Zanelli G, Prouse P, et al. Blood and protein loss via small intestinal inflammation induced by non-steroid anti-inflammatory drugs. Lancet 1987; 2: 711-4.
33. 33 Parrilli G, Iaffaioli RV, Martorano M, et al. Effects of anthracycline therapy on intestinal absorption in patients with advanced breast cancer. Cancer Res 1989; 49: 3689-91.
34. 34 Keefe DM, Cummins AG, Dale BM, Kotasek D, Robb TA, Sage RE. Effect of high-dose chemotherapy on intestinal permeability in humans. Clin Sci Colch 1997; 92: 385-9.
35. 35 Erickson RA, Epsten RM Jr. Oral chenodeoxycholic acid increases small intestinal permeability to lactulose in humans. Am J Gastroenterol 1988; 83: 541-4.
36. 36 Bjarnason I, Ward K, Peters TJ. The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1984; 1: 179-82.
37. 37 Maxton DG, Menzies IS, Slavin B, Thompson RP. Small-intestinal function during enteral feeding and starvation in man. Clin Sci 1989; 77: 401-6.
38. 38 Cummins A, Chu G, Faust L, et al. Malabsorption and villous atrophy in patients receiving enteral feeding. J Parent Enteral Nutr 1995; 19: 193-8.
39. 39 Van der Hulst RR, Van Kreel BK, Von Meyenfeldt MF, et al. Glutamine and the preservation of gut integrity. Lancet 1993; 341: 1363-5.
40. 40 Pals KL, Chang RT, Ryan AJ, Gisolfi CV. Effect of running intensity on intestinal permeability. J Appl Physiol 1997; 82: 571-6.
41. 41 Ryan AJ, Chang RT, Gisolfi CV. Gastrointestinal permeability following aspirin intake and prolonged running. Med Sci Sports Exerc 1996; 28: 698-705.
42. 42 Øktedalen O, Lunde OC, Opstad PK, Aabakken L, Kvernebo K. Changes in the gastrointestinal mucosa after long-distance running. Scand J Gastroenterol 1992; 27: 270-4.
43. 43 Moses F, Singh A, Smoak B, Hollander D, Deuster P. Alterations in intestinal permeability during prolonged high intensity running (Abstract). Gastroenterology 1991; 100: A472.
44. 44 Fernandez Calle P, Codoceo R, Polanco I, Gomez Cerezo J, Orsi M, Tenias JM. Is an intestinal permeability test a valid marker for slight dietary transgression in adolescents with coeliac disease? Gut 1993; 34: 774-7.
45. 45 Menzies IS, Laker MF, Pounder R, et al. Abnormal intestinal permeability to sugars in villous atrophy. Lancet 1979; 24: 1107-9.
46. 46 Dinmore AJ, Edwards JS, Menzies IS, Travis SP. Intestinal carbohydrate absorption and permeability at high altitude (5,730 m). J Appl Physiol 1994; 76: 1903-07.
47. 47 Hadfield RJ, Sinclair DG, Houldsworth PE, Evans TW. Effect of enteral and parenteral nutrition on gut mucosal permeability in the critically ill. Am J Respir Crit Care Med 1995; 152: 1545-8.
48. 48 Johnston JD, Harvey CJ, Menzies IS, Treacher DF. Gastrointestinal permeability and absorptive capacity in sepsis. Crit Care Med 1996; 24: 1144-9.
49. 49 Miki K, Butler R, Moore D, Davidson G. Rapid and simultaneous quantification of rhamnose, mannitol, and lactulose in urine by HPLC for estimating intestinal permeability in pediatric practice. Clin Chem 1996; 42: 71-5.
50. 50 Sinclair DG, Haslam PL, Quinlan GJ, Pepper JR, Evans TW. The effect of cardiopulmonary bypass on intestinal and pulmonary endothelial permeability. Chest 1995; 108: 718-24.
51. 51 Gardner ML, Illingworth KM, Kelleher J, Wood D. Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose. J Physiol 1991; 439: 411-22.
52. 52 Greco L, D'Adamo G, Truscelli A, Parrilli G, Mayer M, Budillon G. Intestinal permeability after single dose gluten challenge in coeliac disease. Arch Dis Child 1991; 66: 870-2.
53. 53 Menzies IS, Jenkins AP, Heduan E, Catt SD, Segal MB, Creamer B. The effect of poorly absorbed solute on intestinal absorption. Scand J Gastroenterol 1990; 25: 1257-64.
54. 54 Griffiths CE, Menzies IS, Barrison IG, Leonard JN, Fry L. Intestinal permeability in dermatitis herpetiformis. J Invest Dermatol 1988; 91: 147-149.
55. 55 Hallberg K, Grzegorczyk A, Larson G, Strandvik B. Intestinal permeability in Cystic Fibrosis in relation to genotype. J Ped Gastroenterol Nutr 1997; 25: 290-5.
56. 56 Sanderson IR, Boulton P, Menzies I, Walker Smith JA. Improvement of abnormal lactulose/rhamnose permeability in active Crohn's disease of the small bowel by an elemental diet. Gut 1987; 28: 1073-6.
57. 57 Ford RP, Menzies IS, Phillips AD, Walker Smith JA, Turner MW. Intestinal sugar permeability: relationship to diarrhoeal disease and small bowel morphology. J Pediatr Gastroenterol Nutr 1985; 4: 568-74.
58. 58 Finzi-Smith J, Cooper E, Bennett F. Lactulose-rhamnose permeability test in Jamaican children. Lancet 1991; 338: 1404.
59. 59 Maxton DG, Catt SD, Menzies IS. Combined assessment of intestinal disaccharidases in congenital asucrasia by differential urinary disaccharide excretion. J Clin Pathol 1990; 43: 406-9.
60. 51Cr, labelled ethylenediamine tetra-acetate, L-rhamnose and polyethyleneglycol 500 as probe markers for assessment in vivo of human intestinal permeability. Clin Sci 1986; 71: 71-80.
61. 61 Ott M, Lembcke B, Staszewski S, Helm EB, Caspary WF. Intestinale Permeabilitat bei Patienten mit erworbenem Immundefekt, syndrom (AIDS). [Intestinal permeability in patients with acquired immunodeficiency syndrome (AIDS)]. Klin Wochenschr 1991; 69: 715-21.
62. 62 Rooyakkers DR, van Eijk HM, Deutz NEP. Simple and sensitive multi-sugar-probe gut permeability test by high-performance liquid chromatography with fluorescence labelling. J Chromatogr A 1996; 730: 99-105.
63. 63 Miller MA, Parkman HP, Urbain JL, et al. Comparison of scintigraphy and lactulose breath hydrogen test for assessment of orocecal transit: lactulose accelerates small bowel transit. Dig Dis Sci 1997; 42 (1): 10-8.